Gene description for Bach2
Gene name BTB and CNC homology 2
Gene symbol Bach2
Other names/aliases E030004N02Rik
Species Mus musculus
 Database cross references - Bach2
ExoCarta ExoCarta_12014
Vesiclepedia VP_12014
Entrez Gene 12014
UniProt P97303  
 Bach2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Bach2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    import into nucleus GO:0051170 IMP
    primary adaptive immune response involving T cells and B cells GO:0090721 IEA
    primary adaptive immune response involving T cells and B cells GO:0090721 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    RNA polymerase II transcription regulator complex GO:0090575 IEA
    RNA polymerase II transcription regulator complex GO:0090575 ISO
 Experiment description of studies that identified Bach2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Bach2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mafk  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
2 Bcl6  
Two-hybrid Mus musculus
Two-hybrid Mus musculus
3 Bcl6b  
Two-hybrid Mus musculus
4 Thrb  
Affinity Capture-MS Mus musculus
5 Prdm1 12142
Phenotypic Suppression Mus musculus
6 Bach2 12014
Two-hybrid Mus musculus
Two-hybrid Mus musculus
7 Zbtb16  
Two-hybrid Mus musculus
8 Ncor2  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Bach2 is involved
No pathways found





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