Gene description for Prdm1
Gene name PR domain containing 1, with ZNF domain
Gene symbol Prdm1
Other names/aliases Blimp-1
Blimp1
PRDI-BF1
ZNFPR1A1
b2b1765Clo
Species Mus musculus
 Database cross references - Prdm1
ExoCarta ExoCarta_12142
Vesiclepedia VP_12142
Entrez Gene 12142
UniProt Q60636  
 Prdm1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Prdm1
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISO
    DNA-binding transcription factor activity GO:0003700 IBA
    protein binding GO:0005515 IPI
    methyltransferase activity GO:0008168 IEA
    metal ion binding GO:0046872 IEA
    histone methyltransferase binding GO:1990226 IPI
    sequence-specific double-stranded DNA binding GO:1990837 ISO
    promoter-specific chromatin binding GO:1990841 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    in utero embryonic development GO:0001701 IMP
    morphogenesis of a branching structure GO:0001763 IMP
    kidney development GO:0001822 IMP
    embryonic placenta development GO:0001892 IMP
    maternal placenta development GO:0001893 IMP
    adaptive immune response GO:0002250 IEA
    heart valve development GO:0003170 IMP
    cardiac septum development GO:0003279 IMP
    ventricular septum development GO:0003281 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IMP
    germ cell development GO:0007281 IGI
    post-embryonic development GO:0009791 IMP
    gene expression GO:0010467 IDA
    positive regulation of gene expression GO:0010628 IDA
    negative regulation of gene expression GO:0010629 IMP
    peptidyl-arginine methylation GO:0018216 IDA
    methylation GO:0032259 IEA
    regulation of natural killer cell differentiation GO:0032823 IMP
    regulation of extrathymic T cell differentiation GO:0033082 IMP
    aorta development GO:0035904 IMP
    regulation of cell population proliferation GO:0042127 IMP
    eye photoreceptor cell development GO:0042462 IMP
    innate immune response GO:0045087 IEA
    cell fate commitment GO:0045165 IBA
    cell fate commitment GO:0045165 IMP
    artery morphogenesis GO:0048844 IGI
    artery morphogenesis GO:0048844 IMP
    regulation of NK T cell differentiation GO:0051136 IMP
    retinal bipolar neuron differentiation GO:0060040 IMP
    intestinal epithelial cell development GO:0060576 IMP
    trophoblast giant cell differentiation GO:0060707 IMP
    coronary vasculature development GO:0060976 IMP
    sebum secreting cell proliferation GO:1990654 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Prdm1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Prdm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ets2  
Reconstituted Complex Mus musculus
2 Prdm1 12142
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
3 Spi1  
Reconstituted Complex Mus musculus
4 Ets1  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
5 PRMT5 10419
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 Zbtb32  
Affinity Capture-Western Mus musculus
7 Bach2 12014
Phenotypic Suppression Mus musculus
8 IRF4  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 Ikbkb 16150
Phenotypic Enhancement Mus musculus
View the network image/svg+xml
 Pathways in which Prdm1 is involved
No pathways found





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