Gene description for AHR
Gene name aryl hydrocarbon receptor
Gene symbol AHR
Other names/aliases bHLHe76
Species Homo sapiens
 Database cross references - AHR
ExoCarta ExoCarta_196
Vesiclepedia VP_196
Entrez Gene 196
HGNC 348
MIM 600253
UniProt P35869  
 AHR identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for AHR
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IBA
    transcription cis-regulatory region binding GO:0000976 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    TFIID-class transcription factor complex binding GO:0001094 IPI
    transcription coactivator binding GO:0001223 IPI
    DNA binding GO:0003677 IDA
    DNA binding GO:0003677 TAS
    DNA-binding transcription factor activity GO:0003700 IDA
    nuclear receptor activity GO:0004879 IDA
    nuclear receptor activity GO:0004879 IDA
    protein binding GO:0005515 IPI
    TBP-class protein binding GO:0017025 IPI
    protein homodimerization activity GO:0042803 ISS
    protein heterodimerization activity GO:0046982 IDA
    Hsp90 protein binding GO:0051879 IDA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    E-box binding GO:0070888 ISS
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    blood vessel development GO:0001568 NAS
    regulation of adaptive immune response GO:0002819 IDA
    negative regulation of T cell mediated immune response to tumor cell GO:0002841 IDA
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    xenobiotic metabolic process GO:0006805 TAS
    apoptotic process GO:0006915 TAS
    response to xenobiotic stimulus GO:0009410 IDA
    response to toxic substance GO:0009636 IDA
    regulation of gene expression GO:0010468 IDA
    intracellular receptor signaling pathway GO:0030522 IEA
    regulation of B cell proliferation GO:0030888 IDA
    circadian regulation of gene expression GO:0032922 ISS
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    negative regulation of inflammatory response GO:0050728 IDA
    cellular response to molecule of bacterial origin GO:0071219 IDA
    cellular response to cAMP GO:0071320 IDA
    cellular response to forskolin GO:1904322 IDA
    cellular response to 2,3,7,8-tetrachlorodibenzodioxine GO:1904613 IDA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    protein-containing complex GO:0032991 IMP
    aryl hydrocarbon receptor complex GO:0034751 IBA
    cytosolic aryl hydrocarbon receptor complex GO:0034752 TAS
    nuclear aryl hydrocarbon receptor complex GO:0034753 IDA
 Experiment description of studies that identified AHR in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for AHR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2F1 2962
Reconstituted Complex Homo sapiens
2 AHR 196
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
3 SP1  
Reconstituted Complex Homo sapiens
4 ARFGAP2 84364
Affinity Capture-MS Homo sapiens
5 TRIM66  
Affinity Capture-MS Homo sapiens
6 BRCA1 672
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 ROCK2 9475
Affinity Capture-MS Homo sapiens
8 TERF2IP 54386
Affinity Capture-MS Homo sapiens
9 DIEXF  
Affinity Capture-MS Homo sapiens
10 SLURP1  
Affinity Capture-MS Homo sapiens
11 SBDS 51119
Affinity Capture-MS Homo sapiens
12 MFAP5  
Affinity Capture-MS Homo sapiens
13 KIAA1598 57698
Affinity Capture-MS Homo sapiens
14 CCDC43 124808
Affinity Capture-MS Homo sapiens
15 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
16 TAF9 6880
Reconstituted Complex Homo sapiens
17 GTF2F2 2963
Reconstituted Complex Homo sapiens
18 COPS5 10987
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 POLR3G  
Affinity Capture-MS Homo sapiens
20 NCOA7  
Reconstituted Complex Homo sapiens
21 ANAPC16  
Affinity Capture-MS Homo sapiens
22 ARNT2  
Reconstituted Complex Homo sapiens
23 KIF14 9928
Affinity Capture-MS Homo sapiens
24 HSPA8 3312
Affinity Capture-MS Homo sapiens
25 NCOA1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
26 RB1 5925
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 BAG5 9529
Affinity Capture-MS Homo sapiens
28 S100A2 6273
Affinity Capture-MS Homo sapiens
29 CHMP1A 5119
Affinity Capture-MS Homo sapiens
30 FOXA1  
Co-localization Homo sapiens
Co-localization Homo sapiens
31 NCOR2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 BTF3L4 91408
Affinity Capture-MS Homo sapiens
33 VRK1 7443
Affinity Capture-MS Homo sapiens
34 SMARCA4 6597
Reconstituted Complex Homo sapiens
35 KIAA1683  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ARNT 405
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
37 LDLRAP1 26119
Affinity Capture-MS Homo sapiens
38 TRIP10 9322
Affinity Capture-MS Homo sapiens
39 CLEC11A 6320
Affinity Capture-MS Homo sapiens
40 E2F1 1869
Affinity Capture-Western Homo sapiens
41 GNA13 10672
Affinity Capture-Western Homo sapiens
42 AIP 9049
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
43 HSPB8 26353
Affinity Capture-MS Homo sapiens
44 CCNT1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
45 NAA25 80018
Affinity Capture-MS Homo sapiens
46 CHMP3 51652
Affinity Capture-MS Homo sapiens
47 TOMM34 10953
Affinity Capture-MS Homo sapiens
48 PPM1M  
Affinity Capture-MS Homo sapiens
49 MRRF  
Affinity Capture-MS Homo sapiens
50 DAP3 7818
Reconstituted Complex Homo sapiens
51 ICAM1 3383
Affinity Capture-MS Homo sapiens
52 XPO1 7514
Affinity Capture-MS Homo sapiens
53 ZNF622 90441
Affinity Capture-MS Homo sapiens
54 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
55 NAA15 80155
Affinity Capture-MS Homo sapiens
56 CUL3 8452
Affinity Capture-MS Homo sapiens
57 KLHDC4 54758
Affinity Capture-MS Homo sapiens
58 PUS7 54517
Affinity Capture-MS Homo sapiens
59 TBP  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
60 C12orf74  
Affinity Capture-MS Homo sapiens
61 CMSS1  
Affinity Capture-MS Homo sapiens
62 SS18L2  
Affinity Capture-MS Homo sapiens
63 IL12RB1  
Affinity Capture-MS Homo sapiens
64 SCGB2A2  
Affinity Capture-MS Homo sapiens
65 DDB1 1642
Affinity Capture-Western Homo sapiens
66 SF3B3 23450
Affinity Capture-MS Homo sapiens
67 NR2F1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
68 TAF4 6874
Reconstituted Complex Homo sapiens
69 STUB1 10273
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
70 ARNTL  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
71 RELA 5970
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
72 TAF6 6878
Reconstituted Complex Homo sapiens
73 FASN 2194
Positive Genetic Homo sapiens
74 STK24 8428
Affinity Capture-MS Homo sapiens
75 SIRT6  
Affinity Capture-MS Homo sapiens
76 PARP1 142
Proximity Label-MS Homo sapiens
77 ROCK1 6093
Affinity Capture-MS Homo sapiens
78 TSPYL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 TRIM52  
Affinity Capture-MS Homo sapiens
80 IVNS1ABP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
81 NCOA2 10499
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
82 RWDD4 201965
Affinity Capture-MS Homo sapiens
83 PBRM1 55193
Negative Genetic Homo sapiens
84 SMAD4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
85 NFE2L2 4780
Co-localization Homo sapiens
86 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
87 UCHL3 7347
Affinity Capture-Western Homo sapiens
88 ESR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
89 DNAJA2 10294
Affinity Capture-MS Homo sapiens
90 EIF3J 8669
Affinity Capture-MS Homo sapiens
91 INF2 64423
Affinity Capture-MS Homo sapiens
92 NRIP1 8204
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
93 PTGES3 10728
Affinity Capture-MS Homo sapiens
94 QRSL1  
Affinity Capture-MS Homo sapiens
95 SH2D4A 63898
Affinity Capture-MS Homo sapiens
96 AR 367
Affinity Capture-Western Homo sapiens
97 CCDC96  
Affinity Capture-MS Homo sapiens
98 UBLCP1  
Affinity Capture-MS Homo sapiens
99 VIM 7431
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
100 EMG1 10436
Affinity Capture-MS Homo sapiens
101 NEDD8 4738
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
102 EP300 2033
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
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