Gene description for NEDD8
Gene name neural precursor cell expressed, developmentally down-regulated 8
Gene symbol NEDD8
Other names/aliases NEDD-8
Species Homo sapiens
 Database cross references - NEDD8
ExoCarta ExoCarta_4738
Vesiclepedia VP_4738
Entrez Gene 4738
HGNC 7732
MIM 603171
UniProt Q15843  
 NEDD8 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Prostate cancer cells 25844599    
 Gene ontology annotations for NEDD8
Molecular Function
    protein binding GO:0005515 IPI
    protein tag activity GO:0031386 IBA
    ubiquitin protein ligase binding GO:0031625 IBA
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    proteolysis GO:0006508 TAS
    ubiquitin-dependent protein catabolic process GO:0006511 TAS
    protein localization GO:0008104 IEA
    anatomical structure morphogenesis GO:0009653 TAS
    protein ubiquitination GO:0016567 IBA
    modification-dependent protein catabolic process GO:0019941 IBA
    regulation of proteolysis GO:0030162 IBA
    protein modification process GO:0036211 TAS
    protein neddylation GO:0045116 IBA
    protein neddylation GO:0045116 IDA
    regulation of postsynapse assembly GO:0150052 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified NEDD8 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for NEDD8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL9 55958
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
3 PSMA6 5687
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 OTUD5 55593
Reconstituted Complex Homo sapiens
6 SKP1 6500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KLHDC10 23008
Affinity Capture-MS Homo sapiens
8 KRT76 51350
Affinity Capture-MS Homo sapiens
9 TST 7263
Co-fractionation Homo sapiens
10 TCEB1 6921
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KRT1 3848
Affinity Capture-MS Homo sapiens
12 RPL15 6138
Affinity Capture-MS Homo sapiens
13 DNAJC8 22826
Co-fractionation Homo sapiens
14 HSPA6 3310
Affinity Capture-MS Homo sapiens
15 MSRB2  
Co-fractionation Homo sapiens
16 KCTD10 83892
Affinity Capture-MS Homo sapiens
17 USP13  
Affinity Capture-MS Homo sapiens
18 PSMA4 5685
Affinity Capture-MS Homo sapiens
19 UBE2M 9040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
20 RPL10P16  
Affinity Capture-MS Homo sapiens
21 COPS6 10980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
22 VPRBP 9730
Affinity Capture-MS Homo sapiens
23 DDX17 10521
Affinity Capture-MS Homo sapiens
24 UCHL1 7345
Two-hybrid Homo sapiens
25 HSPA1L 3305
Affinity Capture-MS Homo sapiens
26 RPSAP12 387867
Affinity Capture-MS Homo sapiens
27 HRAS 3265
Co-fractionation Homo sapiens
28 C9orf78 51759
Affinity Capture-MS Homo sapiens
29 HNRNPC 3183
Affinity Capture-MS Homo sapiens
30 UBC 7316
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
31 SSB 6741
Affinity Capture-MS Homo sapiens
32 PPIA 5478
Affinity Capture-MS Homo sapiens
33 VHL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 HNRNPR 10236
Affinity Capture-MS Homo sapiens
35 SRSF2 6427
Affinity Capture-MS Homo sapiens
36 HSPA1A 3303
Affinity Capture-MS Homo sapiens
37 MYEOV2 150678
Affinity Capture-MS Homo sapiens
38 ILF2 3608
Affinity Capture-MS Homo sapiens
39 KLHDC2  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
40 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
41 TCEB3 6924
Affinity Capture-MS Homo sapiens
42 KBTBD6  
Affinity Capture-MS Homo sapiens
43 PARK2  
Reconstituted Complex Homo sapiens
44 RPS20 6224
Affinity Capture-MS Homo sapiens
45 HNRNPAB 3182
Affinity Capture-MS Homo sapiens
46 MEI1  
Affinity Capture-MS Homo sapiens
47 YWHAZ 7534
Affinity Capture-MS Homo sapiens
48 UBL7  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
49 PSMA3 5684
Affinity Capture-MS Homo sapiens
50 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
51 MATR3 9782
Affinity Capture-MS Homo sapiens
52 DAZAP1 26528
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
53 BRWD3  
Affinity Capture-MS Homo sapiens
54 HGS 9146
Reconstituted Complex Homo sapiens
55 TTN 7273
Affinity Capture-MS Homo sapiens
56 COPS5 10987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
57 GDI1 2664
Co-fractionation Homo sapiens
58 TAF15 8148
Affinity Capture-MS Homo sapiens
59 HIBCH 26275
Co-fractionation Homo sapiens
60 SNRPC 6631
Affinity Capture-MS Homo sapiens
61 KLHL15  
Affinity Capture-MS Homo sapiens
62 RPSAP55  
Affinity Capture-MS Homo sapiens
63 HIST1H2AI 8329
Affinity Capture-MS Homo sapiens
64 EWSR1 2130
Affinity Capture-MS Homo sapiens
65 UBQLN1 29979
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
66 COPS7A 50813
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 NUB1 51667
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
68 HSPH1 10808
Reconstituted Complex Homo sapiens
69 HSPA7 3311
Affinity Capture-MS Homo sapiens
70 TBC1D15 64786
Affinity Capture-MS Homo sapiens
71 TULP3 7289
Affinity Capture-MS Homo sapiens
72 HIST1H2AK 8330
Affinity Capture-MS Homo sapiens
73 CPLX1 10815
Co-fractionation Homo sapiens
74 EEF1G 1937
Affinity Capture-MS Homo sapiens
75 TUBB 203068
Affinity Capture-MS Homo sapiens
76 TIAL1 7073
Affinity Capture-MS Homo sapiens
77 RAB8B 51762
Co-fractionation Homo sapiens
78 RPS3A 6189
Affinity Capture-MS Homo sapiens
79 CTPS1 1503
Affinity Capture-MS Homo sapiens
80 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 BTRC 8945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 CBLB 868
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
83 GPS1 2873
Affinity Capture-MS Homo sapiens
84 NUDT16L1 84309
Affinity Capture-MS Homo sapiens
85 RPLP1 6176
Affinity Capture-MS Homo sapiens
86 YAF2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
87 EEF1A1 1915
Affinity Capture-MS Homo sapiens
88 RAD23A 5886
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
89 SIRT1  
Reconstituted Complex Homo sapiens
90 PRNP 5621
Affinity Capture-MS Homo sapiens
91 OTUB2  
Reconstituted Complex Homo sapiens
92 NUP155 9631
Affinity Capture-MS Homo sapiens
93 MPI 4351
Co-fractionation Homo sapiens
94 ZYX 7791
Affinity Capture-MS Homo sapiens
95 RPL36AP37  
Affinity Capture-MS Homo sapiens
96 CTRC  
Biochemical Activity Homo sapiens
97 ZYG11B  
Affinity Capture-MS Homo sapiens
98 PPP1CA 5499
Reconstituted Complex Homo sapiens
99 NAE1 8883
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 MIB1 57534
Proximity Label-MS Homo sapiens
101 KRT5 3852
Affinity Capture-MS Homo sapiens
102 HNRNPA0 10949
Affinity Capture-MS Homo sapiens
103 RBX1 9978
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 USP11 8237
Affinity Capture-MS Homo sapiens
105 PSMD4 5710
Reconstituted Complex Homo sapiens
106 HMGCS1 3157
Co-fractionation Homo sapiens
107 CUL4B 8450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
108 RPL4 6124
Affinity Capture-MS Homo sapiens
109 RPS10 6204
Affinity Capture-MS Homo sapiens
110 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
111 MSX2  
Affinity Capture-MS Homo sapiens
112 CLNS1A 1207
Co-fractionation Homo sapiens
113 CLTCL1 8218
Affinity Capture-MS Homo sapiens
114 TCEB1P3  
Affinity Capture-MS Homo sapiens
115 RPL5 6125
Affinity Capture-MS Homo sapiens
116 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
117 PABPC1 26986
Affinity Capture-MS Homo sapiens
118 SENP8  
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
119 SNRPD1 6632
Affinity Capture-MS Homo sapiens
120 UBA3 9039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 YAP1 10413
Co-fractionation Homo sapiens
122 DDX5 1655
Affinity Capture-MS Homo sapiens
123 CIRBP 1153
Affinity Capture-MS Homo sapiens
124 RPL31 6160
Affinity Capture-MS Homo sapiens
125 NCL 4691
Affinity Capture-MS Homo sapiens
126 KRT9 3857
Affinity Capture-MS Homo sapiens
127 KHNYN 23351
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
128 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
129 ARIH2 10425
Reconstituted Complex Homo sapiens
130 KRT14 3861
Affinity Capture-MS Homo sapiens
131 RNF187  
Affinity Capture-MS Homo sapiens
132 POLI  
Protein-peptide Homo sapiens
133 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
134 PPA2 27068
Co-fractionation Homo sapiens
135 ACTB 60
Affinity Capture-MS Homo sapiens
136 TUBA1C 84790
Affinity Capture-MS Homo sapiens
137 COPS3 8533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 KRT2 3849
Affinity Capture-MS Homo sapiens
139 UBE2D3 7323
Co-fractionation Homo sapiens
140 MEMO1 51072
Co-fractionation Homo sapiens
141 CUL2 8453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 RPS16 6217
Affinity Capture-MS Homo sapiens
143 COPS7B 64708
Affinity Capture-MS Homo sapiens
144 PMAIP1  
Affinity Capture-MS Homo sapiens
145 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
146 RPS15A 6210
Affinity Capture-MS Homo sapiens
147 EIF3I 8668
Reconstituted Complex Homo sapiens
148 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
149 PRDX5 25824
Co-fractionation Homo sapiens
150 HSPA4L 22824
Reconstituted Complex Homo sapiens
151 IGBP1 3476
Co-fractionation Homo sapiens
152 RPLP0 6175
Affinity Capture-MS Homo sapiens
153 CBFB 865
Affinity Capture-MS Homo sapiens
154 FBXO4 26272
Affinity Capture-MS Homo sapiens
155 RPLP2 6181
Affinity Capture-MS Homo sapiens
156 HNRNPDL 9987
Affinity Capture-MS Homo sapiens
157 HNRNPD 3184
Affinity Capture-MS Homo sapiens
158 RPL23A 6147
Affinity Capture-MS Homo sapiens
159 Brwd3  
Affinity Capture-MS Mus musculus
160 HSPA5 3309
Affinity Capture-MS Homo sapiens
161 KPNA2 3838
Affinity Capture-MS Homo sapiens
162 BPLF1  
Reconstituted Complex
Biochemical Activity
Affinity Capture-Western
163 COPS2 9318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
165 UFC1 51506
Co-fractionation Homo sapiens
166 HIST1H2AL 8332
Affinity Capture-MS Homo sapiens
167 POP1 10940
Co-fractionation Homo sapiens
168 SDHA 6389
Affinity Capture-MS Homo sapiens
169 UBXN7 26043
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
170 RPL35 11224
Affinity Capture-MS Homo sapiens
171 IGHV3OR15-7  
Affinity Capture-MS Homo sapiens
172 AHCY 191
Affinity Capture-MS Homo sapiens
173 KRT75 9119
Affinity Capture-MS Homo sapiens
174 COPS8 10920
Affinity Capture-MS Homo sapiens
175 QPCT 25797
Affinity Capture-MS Homo sapiens
176 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
177 RPS8 6202
Affinity Capture-MS Homo sapiens
178 DCAF13 25879
Affinity Capture-MS Homo sapiens
179 TUBB4B 10383
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
180 PSMA2 5683
Affinity Capture-MS Homo sapiens
181 SEC23A 10484
Affinity Capture-MS Homo sapiens
182 FBXO6 26270
Affinity Capture-MS Homo sapiens
183 FUS 2521
Affinity Capture-MS Homo sapiens
184 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
185 KBTBD7  
Affinity Capture-MS Homo sapiens
186 TNRC6B  
Affinity Capture-MS Homo sapiens
187 CREM  
Affinity Capture-MS Homo sapiens
188 GHR  
Protein-peptide Homo sapiens
189 SPTBN1 6711
Affinity Capture-MS Homo sapiens
190 RPS4X 6191
Affinity Capture-MS Homo sapiens
191 YWHAQ 10971
Affinity Capture-MS Homo sapiens
192 TUBA4A 7277
Affinity Capture-MS Homo sapiens
193 CDK2 1017
Affinity Capture-MS Homo sapiens
194 UBE2D2 7322
Co-crystal Structure Homo sapiens
195 CUL9  
Affinity Capture-MS Homo sapiens
196 DNMT3B  
Reconstituted Complex Homo sapiens
197 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
198 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
199 MYC  
Affinity Capture-MS Homo sapiens
200 AHR 196
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
201 HSP90AA2P 3324
Affinity Capture-MS Homo sapiens
202 EEF1A2 1917
Affinity Capture-MS Homo sapiens
203 HSPA4 3308
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
204 DNAJC10 54431
Affinity Capture-MS Homo sapiens
205 TCEB2 6923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 DDB1 1642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 OTULIN 90268
Affinity Capture-MS Homo sapiens
208 CLTC 1213
Affinity Capture-MS Homo sapiens
209 HSPD1 3329
Affinity Capture-MS Homo sapiens
210 HSPA9 3313
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
211 DDX1 1653
Affinity Capture-MS Homo sapiens
212 Cul4a  
Affinity Capture-MS Mus musculus
213 HIST1H2AJ 8331
Affinity Capture-MS Homo sapiens
214 KRT16 3868
Affinity Capture-MS Homo sapiens
215 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
216 BAG4  
Affinity Capture-MS Homo sapiens
217 DCTPP1 79077
Affinity Capture-MS Homo sapiens
218 ACTBL2 345651
Affinity Capture-MS Homo sapiens
219 DHX9 1660
Affinity Capture-MS Homo sapiens
220 DSP 1832
Affinity Capture-MS Homo sapiens
221 RPL19 6143
Affinity Capture-MS Homo sapiens
222 SHKBP1  
Affinity Capture-MS Homo sapiens
223 YBX1 4904
Affinity Capture-MS Homo sapiens
224 FBXL15  
Affinity Capture-MS Homo sapiens
225 TFG 10342
Affinity Capture-MS Homo sapiens
226 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
227 SPTAN1 6709
Affinity Capture-MS Homo sapiens
228 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
229 RPS3 6188
Affinity Capture-MS Homo sapiens
230 ILF3 3609
Affinity Capture-MS Homo sapiens
231 USP25  
Affinity Capture-MS Homo sapiens
232 H3F3A 3020
Cross-Linking-MS (XL-MS) Homo sapiens
233 TP53 7157
Affinity Capture-MS Homo sapiens
234 RPL6 6128
Affinity Capture-MS Homo sapiens
235 BTBD9  
Affinity Capture-MS Homo sapiens
236 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
237 DNAJA2 10294
Reconstituted Complex Homo sapiens
238 DDX3X 1654
Affinity Capture-MS Homo sapiens
239 HDAC6 10013
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
240 KLHDC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 KRT10 3858
Affinity Capture-MS Homo sapiens
242 GRN 2896
Reconstituted Complex Homo sapiens
243 CUL5 8065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
244 C9orf64 84267
Co-fractionation Homo sapiens
245 ASL 435
Co-fractionation Homo sapiens
246 SMURF1 57154
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
247 G3BP1 10146
Co-localization Homo sapiens
248 SHFM1 7979
Affinity Capture-MS Homo sapiens
249 KCTD3  
Affinity Capture-MS Homo sapiens
250 DCAF11  
Affinity Capture-MS Homo sapiens
251 DFFB  
Affinity Capture-MS Homo sapiens
252 TKT 7086
Co-fractionation Homo sapiens
253 OTUB1 55611
Biochemical Activity Homo sapiens
254 NIT1 4817
Co-fractionation Homo sapiens
255 FEM1B 10116
Affinity Capture-MS Homo sapiens
256 UCHL3 7347
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
257 HNRNPK 3190
Affinity Capture-MS Homo sapiens
258 PSMA1 5682
Affinity Capture-MS Homo sapiens
259 ATP6V1F 9296
Co-fractionation Homo sapiens
260 PCNA 5111
Reconstituted Complex Homo sapiens
261 TFE3  
Affinity Capture-MS Homo sapiens
262 PWP1 11137
Affinity Capture-MS Homo sapiens
263 ASB8  
Affinity Capture-MS Homo sapiens
264 KRT24 192666
Affinity Capture-MS Homo sapiens
265 MAGED1 9500
Affinity Capture-MS Homo sapiens
266 GAPDH 2597
Affinity Capture-MS Homo sapiens
267 PSMA5 5686
Affinity Capture-MS Homo sapiens
268 RPS23 6228
Affinity Capture-MS Homo sapiens
269 HNRNPH3 3189
Affinity Capture-MS Homo sapiens
270 PSMA7 5688
Affinity Capture-MS Homo sapiens
271 YBX3 8531
Affinity Capture-MS Homo sapiens
272 KHSRP 8570
Affinity Capture-MS Homo sapiens
273 SRSF7 6432
Affinity Capture-MS Homo sapiens
274 UBA2 10054
Reconstituted Complex Homo sapiens
275 PRDX1 5052
Affinity Capture-MS Homo sapiens
276 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
277 RPL8 6132
Affinity Capture-MS Homo sapiens
278 HNRNPF 3185
Affinity Capture-MS Homo sapiens
279 KLHL22 84861
Affinity Capture-MS Homo sapiens
280 C1QBP 708
Affinity Capture-MS Homo sapiens
281 SERBP1 26135
Affinity Capture-MS Homo sapiens
282 RPL11 6135
Affinity Capture-MS Homo sapiens
283 KRT13 3860
Affinity Capture-MS Homo sapiens
284 CUL7 9820
Affinity Capture-MS Homo sapiens
285 KRAS 3845
Negative Genetic Homo sapiens
286 HNRNPU 3192
Affinity Capture-MS Homo sapiens
287 OR4S2  
Co-fractionation Homo sapiens
288 RPL7AP9  
Affinity Capture-MS Homo sapiens
289 SMURF2 64750
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
290 YWHAE 7531
Affinity Capture-MS Homo sapiens
291 ATXN3 4287
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
292 COPS4 51138
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
293 KLHL12  
Affinity Capture-MS Homo sapiens
294 FBXO3  
Affinity Capture-MS Homo sapiens
295 STRBP 55342
Affinity Capture-MS Homo sapiens
296 NDUFS6  
Co-fractionation Homo sapiens
297 HSPA1B 3304
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
298 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
299 NEDD8 4738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
300 ARIH1 25820
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
301 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
302 N4BP1  
Reconstituted Complex Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here