Gene description for ITPR3
Gene name inositol 1,4,5-trisphosphate receptor, type 3
Gene symbol ITPR3
Other names/aliases IP3R
IP3R3
Species Homo sapiens
 Database cross references - ITPR3
ExoCarta ExoCarta_3710
Vesiclepedia VP_3710
Entrez Gene 3710
HGNC 6182
MIM 147267
UniProt Q14573  
 ITPR3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Neuroblastoma cells 25944692    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ITPR3
Molecular Function
    inositol hexakisphosphate binding GO:0000822 ISS
    inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0005220 IBA
    inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0005220 IDA
    inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0005220 ISS
    calcium ion binding GO:0005509 IBA
    protein binding GO:0005515 IPI
    intracellularly gated calcium channel activity GO:0015278 ISS
    intracellularly gated calcium channel activity GO:0015278 TAS
    phosphatidylinositol binding GO:0035091 IBA
    inositol 1,3,4,5 tetrakisphosphate binding GO:0043533 ISS
    inositol 1,4,5 trisphosphate binding GO:0070679 IBA
    inositol 1,4,5 trisphosphate binding GO:0070679 IDA
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 ISS
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISS
    memory GO:0007613 IEA
    calcium-mediated signaling GO:0019722 IEA
    platelet activation GO:0030168 IDA
    sensory perception of taste GO:0050909 TAS
    sensory perception of bitter taste GO:0050913 IEA
    sensory perception of sweet taste GO:0050916 IEA
    sensory perception of umami taste GO:0050917 IEA
    release of sequestered calcium ion into cytosol GO:0051209 IBA
    protein homotetramerization GO:0051289 IDA
    response to calcium ion GO:0051592 IDA
    calcium ion homeostasis GO:0055074 IMP
    long-term synaptic potentiation GO:0060291 IEA
Subcellular Localization
    nuclear outer membrane GO:0005640 ISS
    nucleoplasm GO:0005654 IEA
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    brush border GO:0005903 ISS
    membrane GO:0016020 HDA
    sarcoplasmic reticulum GO:0016529 IBA
    transport vesicle membrane GO:0030658 IEA
    secretory granule membrane GO:0030667 IBA
    platelet dense tubular network membrane GO:0031095 TAS
    neuronal cell body GO:0043025 ISS
    receptor complex GO:0043235 IDA
    apical part of cell GO:0045177 ISS
    cytoplasmic side of endoplasmic reticulum membrane GO:0098554 ISS
 Experiment description of studies that identified ITPR3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
7
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ITPR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTR2 10097
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 CABP2  
Affinity Capture-MS Homo sapiens
4 VAPA 9218
Affinity Capture-MS Homo sapiens
5 METTL7A 25840
Proximity Label-MS Homo sapiens
6 LAMP3  
Proximity Label-MS Homo sapiens
7 GJA1 2697
Proximity Label-MS Homo sapiens
8 BTF3 689
Affinity Capture-MS Homo sapiens
9 Calml3  
Affinity Capture-MS Mus musculus
10 CTDNEP1 23399
Proximity Label-MS Homo sapiens
11 GJD3  
Proximity Label-MS Homo sapiens
12 LAMP2 3920
Proximity Label-MS Homo sapiens
13 DNAJC25 548645
Proximity Label-MS Homo sapiens
14 PTPN1 5770
Proximity Label-MS Homo sapiens
15 Actb 11461
Affinity Capture-MS Mus musculus
16 Ktn1  
Affinity Capture-MS Mus musculus
17 STX4 6810
Proximity Label-MS Homo sapiens
18 ABCD1 215
Co-fractionation Homo sapiens
19 LRPPRC 10128
Affinity Capture-MS Homo sapiens
20 DPPA4  
Affinity Capture-MS Homo sapiens
21 CAPZB 832
Affinity Capture-MS Homo sapiens
22 PPL 5493
Affinity Capture-MS Homo sapiens
23 B3GAT1  
Proximity Label-MS Homo sapiens
24 TGFB1 7040
Affinity Capture-MS Homo sapiens
25 KIF23 9493
Affinity Capture-MS Homo sapiens
26 TCTEX1D1  
Affinity Capture-MS Homo sapiens
27 STIM2 57620
Affinity Capture-MS Homo sapiens
28 NPPB  
Affinity Capture-MS Homo sapiens
29 BBOX1 8424
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CALM3 808
Affinity Capture-MS Homo sapiens
31 MAGEA9  
Affinity Capture-MS Homo sapiens
32 POU5F1  
Affinity Capture-MS Homo sapiens
33 SIGMAR1 10280
Affinity Capture-Western Homo sapiens
34 SSR1 6745
Proximity Label-MS Homo sapiens
35 OBSL1 23363
Affinity Capture-MS Homo sapiens
36 PIGH  
Affinity Capture-MS Homo sapiens
37 RANBP2 5903
Affinity Capture-MS Homo sapiens
38 C3orf52  
Affinity Capture-MS Homo sapiens
39 FANCD2  
Affinity Capture-MS Homo sapiens
40 CENPQ  
Affinity Capture-MS Homo sapiens
41 TESPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SLC25A46 91137
Proximity Label-MS Homo sapiens
43 DNAJC7 7266
Proximity Label-MS Homo sapiens
44 ATG16L1 55054
Affinity Capture-MS Homo sapiens
45 KRT83  
Affinity Capture-MS Homo sapiens
46 TACO1  
Proximity Label-MS Homo sapiens
47 CSNK2B 1460
Affinity Capture-MS Homo sapiens
48 COMMD4 54939
Affinity Capture-MS Homo sapiens
49 MARCH5  
Affinity Capture-MS Homo sapiens
50 KIF14 9928
Affinity Capture-MS Homo sapiens
51 LMAN1 3998
Proximity Label-MS Homo sapiens
52 MTNR1B  
Two-hybrid Homo sapiens
53 NUP155 9631
Proximity Label-MS Homo sapiens
54 KIAA1715 80856
Proximity Label-MS Homo sapiens
55 PXMP2  
Proximity Label-MS Homo sapiens
56 CHMP4C 92421
Affinity Capture-MS Homo sapiens
57 FAM19A4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CALD1 800
Affinity Capture-MS Homo sapiens
59 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
60 EMD 2010
Proximity Label-MS Homo sapiens
61 TRPC4  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
62 CALML3 810
Affinity Capture-MS Homo sapiens
63 RAB4A 5867
Proximity Label-MS Homo sapiens
64 TRPC2  
Reconstituted Complex Homo sapiens
65 CAMK2G 818
Affinity Capture-MS Homo sapiens
66 TRPC1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
67 RB1CC1 9821
Affinity Capture-MS Homo sapiens
68 CHMP4B 128866
Affinity Capture-MS Homo sapiens
69 RPA2 6118
Proximity Label-MS Homo sapiens
70 MYH9 4627
Affinity Capture-MS Homo sapiens
71 RASEF  
Affinity Capture-MS Homo sapiens
72 KRIT1 889
Affinity Capture-MS Homo sapiens
73 CCDC107  
Affinity Capture-MS Homo sapiens
74 DHFRL1  
Proximity Label-MS Homo sapiens
75 L3MBTL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 DNAJB5  
Proximity Label-MS Homo sapiens
77 RHOT2 89941
Proximity Label-MS Homo sapiens
78 ELOVL5 60481
Proximity Label-MS Homo sapiens
79 SEC61B 10952
Proximity Label-MS Homo sapiens
80 SNAP29 9342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 PKD2L2 27039
Affinity Capture-MS Homo sapiens
82 REEP5 7905
Proximity Label-MS Homo sapiens
83 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 HTR3A  
Affinity Capture-MS Homo sapiens
85 LIMA1 51474
Affinity Capture-MS Homo sapiens
86 SEC63 11231
Proximity Label-MS Homo sapiens
87 CNGA4  
Affinity Capture-MS Homo sapiens
88 HSD3B7 80270
Proximity Label-MS Homo sapiens
89 ITPR2 3709
Affinity Capture-MS Homo sapiens
90 Myh9 17886
Affinity Capture-MS Mus musculus
91 Cd2ap 12488
Affinity Capture-MS Mus musculus
92 CANX 821
Affinity Capture-MS Homo sapiens
93 RAB7A 7879
Proximity Label-MS Homo sapiens
94 LRRC59 55379
Proximity Label-MS Homo sapiens
95 LMNB1 4001
Proximity Label-MS Homo sapiens
96 RNF170 81790
Affinity Capture-MS Homo sapiens
97 FBXL2  
Affinity Capture-Western Homo sapiens
98 SIRT7  
Affinity Capture-MS Homo sapiens
99 BCAP31 10134
Proximity Label-MS Homo sapiens
100 RAB29 8934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 COMMD2 51122
Affinity Capture-MS Homo sapiens
102 NR3C1 2908
Proximity Label-MS Homo sapiens
103 STIM1 6786
Proximity Label-MS Homo sapiens
104 MTNR1A  
Two-hybrid Homo sapiens
105 FKBP8 23770
Proximity Label-MS Homo sapiens
106 MYO19  
Affinity Capture-MS Homo sapiens
107 RPN2 6185
Proximity Label-MS Homo sapiens
108 Evpl  
Affinity Capture-MS Mus musculus
109 PRKACA 5566
Proximity Label-MS Homo sapiens
110 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 SYNPO 11346
Affinity Capture-MS Homo sapiens
112 RPA3 6119
Proximity Label-MS Homo sapiens
113 ATP2A1 487
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
114 RAB9A 9367
Proximity Label-MS Homo sapiens
115 TRPC7  
Reconstituted Complex Homo sapiens
116 PCGF1 84759
Affinity Capture-MS Homo sapiens
117 RPN1 6184
Proximity Label-MS Homo sapiens
118 CYP2C9  
Proximity Label-MS Homo sapiens
119 TRPC6 7225
Reconstituted Complex Homo sapiens
120 AKT1 207
Biochemical Activity Homo sapiens
121 NANOG  
Affinity Capture-MS Homo sapiens
122 PEX3 8504
Proximity Label-MS Homo sapiens
123 STX17 55014
Affinity Capture-MS Homo sapiens
124 AKAP1 8165
Proximity Label-MS Homo sapiens
125 GNL3 26354
Affinity Capture-MS Homo sapiens
126 CCDC8  
Affinity Capture-MS Homo sapiens
127 AHSA1 10598
Affinity Capture-MS Homo sapiens
128 KRT18 3875
Proximity Label-MS Homo sapiens
129 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
130 PSMB10 5699
Affinity Capture-MS Homo sapiens
131 TSFM 10102
Proximity Label-MS Homo sapiens
132 SIRT6  
Affinity Capture-MS Homo sapiens
133 BKRF1  
Affinity Capture-MS
134 GPI 2821
Affinity Capture-MS Homo sapiens
135 TRPC5  
Reconstituted Complex Homo sapiens
136 Myo1c 17913
Affinity Capture-MS Mus musculus
137 CAPZA2 830
Affinity Capture-MS Homo sapiens
138 TRPC3  
Reconstituted Complex Homo sapiens
139 ERGIC1 57222
Proximity Label-MS Homo sapiens
140 ATP2A2 488
Co-fractionation Homo sapiens
141 NIFK 84365
Proximity Label-MS Homo sapiens
142 Myh10 77579
Affinity Capture-MS Mus musculus
143 FGL2 10875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 ERGIC2 51290
Proximity Label-MS Homo sapiens
145 CCDC101  
Affinity Capture-MS Homo sapiens
146 SEC62 7095
Proximity Label-MS Homo sapiens
147 ZNRF4  
Affinity Capture-MS Homo sapiens
148 FLNA 2316
Affinity Capture-MS Homo sapiens
149 RAB11A 8766
Proximity Label-MS Homo sapiens
150 GOT1 2805
Affinity Capture-MS Homo sapiens
151 CIT 11113
Affinity Capture-MS Homo sapiens
152 TNNC2  
Affinity Capture-MS Homo sapiens
153 ITPR1 3708
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
154 DNAJC1 64215
Proximity Label-MS Homo sapiens
155 RAB5C 5878
Proximity Label-MS Homo sapiens
156 CCR6  
Affinity Capture-MS Homo sapiens
157 HSPA12A 259217
Affinity Capture-MS Homo sapiens
158 CHRNA3 1136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 DERL1 79139
Proximity Label-MS Homo sapiens
160 MRVI1 10335
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ITPR3 is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Adaptive Immune System TAS Reactome
Anti-inflammatory response favouring Leishmania parasite infection IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
Beta-catenin independent WNT signaling IEA Reactome
C-type lectin receptors (CLRs) IEA Reactome
Ca2+ pathway IEA Reactome
Cardiac conduction IEA Reactome
Cardiac conduction TAS Reactome
CLEC7A (Dectin-1) induces NFAT activation IEA Reactome
CLEC7A (Dectin-1) signaling IEA Reactome
DAG and IP3 signaling IEA Reactome
Disease IEA Reactome
Effects of PIP2 hydrolysis TAS Reactome
Elevation of cytosolic Ca2+ levels TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
FCGR3A-mediated IL10 synthesis IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (q) signalling events TAS Reactome
G-protein mediated events IEA Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion TAS Reactome
GPCR downstream signalling IEA Reactome
GPCR downstream signalling TAS Reactome
Hemostasis TAS Reactome
Immune System IEA Reactome
Immune System TAS Reactome
Infectious disease IEA Reactome
Innate Immune System IEA Reactome
Integration of energy metabolism IEA Reactome
Integration of energy metabolism TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Ion homeostasis IEA Reactome
Ion homeostasis TAS Reactome
Leishmania infection IEA Reactome
Leishmania parasite growth and survival IEA Reactome
Metabolism IEA Reactome
Metabolism TAS Reactome
Muscle contraction IEA Reactome
Muscle contraction TAS Reactome
Opioid Signalling IEA Reactome
Parasitic Infection Pathways IEA Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet calcium homeostasis TAS Reactome
Platelet homeostasis TAS Reactome
PLC beta mediated events IEA Reactome
Regulation of insulin secretion IEA Reactome
Regulation of insulin secretion TAS Reactome
Role of phospholipids in phagocytosis IEA Reactome
Sensory Perception TAS Reactome
Sensory perception of sweet, bitter, and umami (glutamate) taste TAS Reactome
Sensory perception of taste TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by GPCR TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by VEGF IEA Reactome
Signaling by WNT IEA Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFR2 mediated cell proliferation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here