Gene description for KRT18
Gene name keratin 18, type I
Gene symbol KRT18
Other names/aliases CYK18
K18
Species Homo sapiens
 Database cross references - KRT18
ExoCarta ExoCarta_3875
Vesiclepedia VP_3875
Entrez Gene 3875
HGNC 6430
MIM 148070
UniProt P05783  
 KRT18 identified in sEVs derived from the following tissue/cell type
Bladder cancer cells 20224111    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Liver cancer cells 25265333    
Liver cancer cells 25265333    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25857301    
Prostate cancer cells 25844599    
Saliva 19199708    
T lymphocytes 34108659    
 Gene ontology annotations for KRT18
Molecular Function
    RNA binding GO:0003723 HDA
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 IPI
    cadherin binding involved in cell-cell adhesion GO:0098641 HDA
Biological Process
    anatomical structure morphogenesis GO:0009653 TAS
    tumor necrosis factor-mediated signaling pathway GO:0033209 IEA
    Golgi to plasma membrane protein transport GO:0043001 IDA
    negative regulation of apoptotic process GO:0043066 IDA
    intermediate filament cytoskeleton organization GO:0045104 IBA
    intermediate filament cytoskeleton organization GO:0045104 IDA
    extrinsic apoptotic signaling pathway GO:0097191 IEA
    hepatocyte apoptotic process GO:0097284 IEA
    cell-cell adhesion GO:0098609 IEA
Subcellular Localization
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 IDA
    microtubule organizing center GO:0005815 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 IDA
    adherens junction GO:0005912 HDA
    nuclear matrix GO:0016363 IEA
    centriolar satellite GO:0034451 IDA
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IDA
    keratin filament GO:0045095 IPI
    perinuclear region of cytoplasm GO:0048471 IEA
    extracellular exosome GO:0070062 HDA
    cell periphery GO:0071944 IEA
 Experiment description of studies that identified KRT18 in sEVs
1
Experiment ID 76
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
Western blotting
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 412
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 414
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
4
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 498
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 20
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
9
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
10
Experiment ID 407
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 405
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 234
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
20
Experiment ID 235
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
21
Experiment ID 236
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
22
Experiment ID 237
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
23
Experiment ID 266
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Wild type
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 268
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx-null HBV replicon plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
25
Experiment ID 417
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 411
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
28
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
29
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 219
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 220
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 221
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
33
Experiment ID 413
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
35
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
36
Experiment ID 406
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 415
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
38
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
39
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
40
Experiment ID 408
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
41
Experiment ID 409
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
42
Experiment ID 416
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
43
Experiment ID 250
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western 1blotting
PubMed ID 25857301    
Organism Homo sapiens
Experiment description Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles.
Authors "Minciacchi VR, You S, Spinelli C, Morley S, Zandian M, Aspuria PJ, Cavallini L, Ciardiello C, Reis Sobreiro M, Morello M, Kharmate G, Jang SC, Kim DK, Hosseini-Beheshti E, Tomlinson Guns E, Gleave M, Gho YS, Mathivanan S, Yang W, Freeman MR, Di Vizio D"
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - expressing DIAPH3 hRNA
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
44
Experiment ID 275
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
45
Experiment ID 66
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
46
Experiment ID 410
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for KRT18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 TBC1D31  
Proximity Label-MS Homo sapiens
3 SLC25A13 10165
Proximity Label-MS Homo sapiens
4 HNRNPC 3183
Co-fractionation Homo sapiens
5 CLEC3B 7123
Affinity Capture-MS Homo sapiens
6 BIRC6 57448
Proximity Label-MS Homo sapiens
7 FLG 2312
Cross-Linking-MS (XL-MS) Homo sapiens
8 KRT1 3848
Cross-Linking-MS (XL-MS) Homo sapiens
9 RAB1A 5861
Co-fractionation Homo sapiens
10 POT1  
Two-hybrid Homo sapiens
11 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
12 SYCE1  
Two-hybrid Homo sapiens
13 KIFC3 3801
Two-hybrid Homo sapiens
14 PKP2 5318
Reconstituted Complex Homo sapiens
15 EIF4E 1977
Co-fractionation Homo sapiens
16 KRT6A 3853
Two-hybrid Homo sapiens
17 MCC 4163
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
18 GIT2 9815
Two-hybrid Homo sapiens
19 APC  
Proximity Label-MS Homo sapiens
20 GFAP 2670
Proximity Label-MS Homo sapiens
21 RBX1 9978
Co-fractionation Homo sapiens
22 HRAS 3265
Two-hybrid Homo sapiens
23 TRADD 8717
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
24 PSMC3 5702
Co-fractionation Homo sapiens
25 RPL14 9045
Co-fractionation Homo sapiens
26 PPP2R1A 5518
Co-fractionation Homo sapiens
27 XRN2 22803
Co-fractionation Homo sapiens
28 KPNA2 3838
Two-hybrid Homo sapiens
29 HNRNPR 10236
Co-fractionation Homo sapiens
30 KIF7 374654
Proximity Label-MS Homo sapiens
31 GFRA1 2674
Co-fractionation Homo sapiens
32 CEP97 79598
Proximity Label-MS Homo sapiens
33 NUP160 23279
Proximity Label-MS Homo sapiens
34 SF3B2 10992
Co-fractionation Homo sapiens
35 DNAJB6 10049
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
36 CSPP1  
Proximity Label-MS Homo sapiens
37 KIAA1429 25962
Affinity Capture-MS Homo sapiens
38 TPGS1  
Proximity Label-MS Homo sapiens
39 ERO1L 30001
Co-fractionation Homo sapiens
40 WDR76  
Affinity Capture-MS Homo sapiens
41 NMT1 4836
Co-fractionation Homo sapiens
42 C11orf30  
Affinity Capture-MS Homo sapiens
43 CNOT10 25904
Proximity Label-MS Homo sapiens
44 CCDC138  
Proximity Label-MS Homo sapiens
45 IFT74 80173
Proximity Label-MS Homo sapiens
46 TGFB1 7040
Affinity Capture-MS Homo sapiens
47 MCM2 4171
Affinity Capture-MS Homo sapiens
48 NME7 29922
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 HGS 9146
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 CCDC14  
Proximity Label-MS Homo sapiens
51 LASP1 3927
Affinity Capture-MS Homo sapiens
52 FKBP3 2287
Co-fractionation Homo sapiens
53 ERC1 23085
Proximity Label-MS Homo sapiens
54 NPM1 4869
Co-fractionation Homo sapiens
55 ORC5  
Two-hybrid Homo sapiens
56 YWHAG 7532
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
57 OBSL1 23363
Affinity Capture-MS Homo sapiens
58 LONP1 9361
Co-fractionation Homo sapiens
59 KRT5 3852
Co-purification Homo sapiens
60 DLG5 9231
Proximity Label-MS Homo sapiens
61 DEDD  
Affinity Capture-Western Homo sapiens
62 DYNLL1 8655
Affinity Capture-MS Homo sapiens
63 ALK 238
Affinity Capture-MS Homo sapiens
64 ITGA4 3676
Affinity Capture-MS Homo sapiens
65 EED  
Affinity Capture-MS Homo sapiens
66 CCDC18  
Proximity Label-MS Homo sapiens
67 VCAM1 7412
Affinity Capture-MS Homo sapiens
68 KHDRBS1 10657
Co-fractionation Homo sapiens
69 NSFL1C 55968
Proximity Label-MS Homo sapiens
70 HUWE1 10075
Affinity Capture-MS Homo sapiens
71 WBP2 23558
Reconstituted Complex Homo sapiens
72 WDR5 11091
Co-fractionation Homo sapiens
73 FAF2 23197
Affinity Capture-MS Homo sapiens
74 TNFRSF1B  
Reconstituted Complex Homo sapiens
75 RCOR3  
Two-hybrid Homo sapiens
76 PDZRN3 23024
Proximity Label-MS Homo sapiens
77 PABPC4 8761
Co-fractionation Homo sapiens
78 HAUS4  
Proximity Label-MS Homo sapiens
79 KIF14 9928
Proximity Label-MS Homo sapiens
80 CEP44  
Proximity Label-MS Homo sapiens
81 PRDX3 10935
Co-fractionation Homo sapiens
82 GARS 2617
Co-fractionation Homo sapiens
83 PPM1B 5495
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
84 KRT8 3856
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
85 KIAA1217 56243
Proximity Label-MS Homo sapiens
86 PCNT  
Proximity Label-MS Homo sapiens
87 CEP350 9857
Proximity Label-MS Homo sapiens
88 SLC25A10 1468
Proximity Label-MS Homo sapiens
89 PSMD1 5707
Proximity Label-MS Homo sapiens
90 HAUS1  
Two-hybrid Homo sapiens
91 RNF4 6047
Affinity Capture-MS Homo sapiens
92 TRIM26 7726
Affinity Capture-MS Homo sapiens
93 FASTKD5  
Proximity Label-MS Homo sapiens
94 PRPH 5630
Proximity Label-MS Homo sapiens
95 HMGCS1 3157
Co-fractionation Homo sapiens
96 RB1CC1 9821
Affinity Capture-MS Homo sapiens
97 MAP1B 4131
Affinity Capture-MS Homo sapiens
98 PIAS4  
Two-hybrid Homo sapiens
99 CFAP46  
Cross-Linking-MS (XL-MS) Homo sapiens
100 TXN 7295
Co-fractionation Homo sapiens
101 ACLY 47
Co-fractionation Homo sapiens
102 TUBGCP4 27229
Two-hybrid Homo sapiens
103 DARS 1615
Co-fractionation Homo sapiens
104 CBL 867
Two-hybrid Homo sapiens
105 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
106 ATF2  
Affinity Capture-MS Homo sapiens
107 OFD1 8481
Proximity Label-MS Homo sapiens
108 HIST1H3E 8353
Co-purification Homo sapiens
109 CEP152  
Proximity Label-MS Homo sapiens
110 CREBRF  
Cross-Linking-MS (XL-MS) Homo sapiens
111 PABPC1 26986
Co-fractionation Homo sapiens
112 CDH1 999
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
113 CEP162  
Proximity Label-MS Homo sapiens
114 CNOT1 23019
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
115 BTF3 689
Affinity Capture-MS Homo sapiens
116 HAUS8  
Proximity Label-MS Homo sapiens
117 SIPA1L2  
Proximity Label-MS Homo sapiens
118 G6PD 2539
Co-fractionation Homo sapiens
119 PPP1R13B  
Proximity Label-MS Homo sapiens
120 TEKT4  
Two-hybrid Homo sapiens
121 NOS2  
Affinity Capture-MS Homo sapiens
122 FLNB 2317
Co-fractionation Homo sapiens
123 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
124 ACTB 60
Co-fractionation Homo sapiens
125 GANAB 23193
Co-fractionation Homo sapiens
126 DDX1 1653
Co-fractionation Homo sapiens
127 PAK2 5062
Co-fractionation Homo sapiens
128 HECTD1 25831
Proximity Label-MS Homo sapiens
129 PKM 5315
Co-fractionation Homo sapiens
130 CTR9 9646
Cross-Linking-MS (XL-MS) Homo sapiens
131 PKP3 11187
Two-hybrid Homo sapiens
132 CEP72  
Proximity Label-MS Homo sapiens
133 NUDC 10726
Co-fractionation Homo sapiens
134 ANKRD26 22852
Proximity Label-MS Homo sapiens
135 KRT79 338785
Two-hybrid Homo sapiens
136 UBA1 7317
Co-fractionation Homo sapiens
137 PRKCE 5581
Affinity Capture-Western Homo sapiens
138 TXNDC11 51061
Two-hybrid Homo sapiens
139 USP32 84669
Affinity Capture-MS Homo sapiens
140 SSX2IP  
Proximity Label-MS Homo sapiens
141 RPL11 6135
Affinity Capture-MS Homo sapiens
142 SP1  
Co-fractionation Homo sapiens
143 TXN2 25828
Two-hybrid Homo sapiens
144 MAT2A 4144
Co-fractionation Homo sapiens
145 CDC14A  
Proximity Label-MS Homo sapiens
146 PHLPP1  
Proximity Label-MS Homo sapiens
147 KRT72 140807
Two-hybrid Homo sapiens
148 CEP128  
Proximity Label-MS Homo sapiens
149 PTPN11 5781
Co-fractionation Homo sapiens
150 FAM83B  
Proximity Label-MS Homo sapiens
151 IPO5 3843
Co-fractionation Homo sapiens
152 CEP192 55125
Proximity Label-MS Homo sapiens
153 FANCD2  
Affinity Capture-MS Homo sapiens
154 METTL14  
Affinity Capture-MS Homo sapiens
155 CEP63  
Proximity Label-MS Homo sapiens
156 TRIM36  
Proximity Label-MS Homo sapiens
157 SMARCD1 6602
Two-hybrid Homo sapiens
158 SEC13 6396
Co-fractionation Homo sapiens
159 PNN 5411
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
160 PSMC6 5706
Co-fractionation Homo sapiens
161 TUFM 7284
Co-fractionation Homo sapiens
162 TRPM7 54822
Proximity Label-MS Homo sapiens
163 IQCB1  
Affinity Capture-MS Homo sapiens
164 RFC2 5982
Co-fractionation Homo sapiens
165 EPPK1 83481
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 CAD 790
Proximity Label-MS Homo sapiens
167 CUL3 8452
Affinity Capture-MS Homo sapiens
168 CCP110  
Proximity Label-MS Homo sapiens
169 TXNRD1 7296
Co-fractionation Homo sapiens
170 EGFR 1956
Negative Genetic Homo sapiens
171 FBXO6 26270
Affinity Capture-MS Homo sapiens
172 PKD1 5310
Reconstituted Complex Homo sapiens
173 CCDC22 28952
Proximity Label-MS Homo sapiens
174 MYO5C 55930
Proximity Label-MS Homo sapiens
175 FN1 2335
Affinity Capture-MS Homo sapiens
176 HEXA 3073
Co-fractionation Homo sapiens
177 TNRC6A 27327
Proximity Label-MS Homo sapiens
178 YTHDC1  
Two-hybrid Homo sapiens
179 CEP55 55165
Proximity Label-MS Homo sapiens
180 KRT15 3866
Two-hybrid Homo sapiens
181 CDC42BPA 8476
Affinity Capture-MS Homo sapiens
182 TMEM57  
Proximity Label-MS Homo sapiens
183 CCDC77  
Proximity Label-MS Homo sapiens
184 ALDH3A2 224
Proximity Label-MS Homo sapiens
185 RPGRIP1L 23322
Proximity Label-MS Homo sapiens
186 NEFM 4741
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
187 RPA3 6119
Proximity Label-MS Homo sapiens
188 NIN 51199
Proximity Label-MS Homo sapiens
189 CNTROB  
Proximity Label-MS Homo sapiens
190 FDPS 2224
Co-fractionation Homo sapiens
191 SEC16A 9919
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
192 CCDC85B  
Two-hybrid Homo sapiens
193 TXNL1 9352
Proximity Label-MS Homo sapiens
194 FRAT1 10023
Two-hybrid Homo sapiens
195 HSPA4 3308
Reconstituted Complex Homo sapiens
196 DNAJC3 5611
Co-fractionation Homo sapiens
197 SNX2 6643
Proximity Label-MS Homo sapiens
198 FLII 2314
Co-fractionation Homo sapiens
199 KIAA1671  
Proximity Label-MS Homo sapiens
200 CRYBG3  
Proximity Label-MS Homo sapiens
201 CLTC 1213
Co-fractionation Homo sapiens
202 CTNNA1 1495
Co-fractionation Homo sapiens
203 PML 5371
Affinity Capture-MS Homo sapiens
204 TACC3  
Proximity Label-MS Homo sapiens
205 KRT19 3880
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
206 PPFIA1 8500
Proximity Label-MS Homo sapiens
207 KIAA0753  
Proximity Label-MS Homo sapiens
208 UPF2 26019
Two-hybrid Homo sapiens
209 ABCD3 5825
Proximity Label-MS Homo sapiens
210 TCHP  
Proximity Label-MS Homo sapiens
211 COL17A1 1308
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
212 HDGF 3068
Co-fractionation Homo sapiens
213 HAUS3  
Proximity Label-MS Homo sapiens
214 CCDC8  
Affinity Capture-MS Homo sapiens
215 EIF3H 8667
Affinity Capture-MS Homo sapiens
216 DSP 1832
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
217 MPHOSPH9  
Proximity Label-MS Homo sapiens
218 KIF15 56992
Proximity Label-MS Homo sapiens
219 NES 10763
Proximity Label-MS Homo sapiens
220 KRT18 3875
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
221 DHX15 1665
Co-fractionation Homo sapiens
222 SPICE1  
Proximity Label-MS Homo sapiens
223 EIF3F 8665
Affinity Capture-MS Homo sapiens
224 CEP290  
Proximity Label-MS Homo sapiens
225 SLC25A11 8402
Proximity Label-MS Homo sapiens
226 GRN 2896
Two-hybrid Homo sapiens
227 SPOP  
Affinity Capture-MS Homo sapiens
228 LRRC49  
Proximity Label-MS Homo sapiens
229 ALMS1  
Proximity Label-MS Homo sapiens
230 KNTC1 9735
Proximity Label-MS Homo sapiens
231 NUP205 23165
Proximity Label-MS Homo sapiens
232 PDE4B  
Protein-RNA Homo sapiens
233 GRB2 2885
Affinity Capture-MS Homo sapiens
234 SVIL 6840
Two-hybrid Homo sapiens
235 FOXRED2  
Affinity Capture-MS Homo sapiens
236 PLEC 5339
Proximity Label-MS Homo sapiens
237 EXOC8 149371
Two-hybrid Homo sapiens
238 CCHCR1  
Two-hybrid Homo sapiens
239 CCDC146  
Two-hybrid Homo sapiens
240 MCM5 4174
Affinity Capture-MS Homo sapiens
241 SDCCAG3  
Proximity Label-MS Homo sapiens
242 ITPR3 3710
Proximity Label-MS Homo sapiens
243 IKBKG 8517
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
244 RBMX 27316
Co-fractionation Homo sapiens
245 ODF2L  
Proximity Label-MS Homo sapiens
246 HSPB1 3315
Two-hybrid Homo sapiens
247 RCHY1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
248 HAUS5 23354
Proximity Label-MS Homo sapiens
249 KRT71 112802
Two-hybrid Homo sapiens
250 CEP131 22994
Proximity Label-MS Homo sapiens
251 FAM83H 286077
Proximity Label-MS Homo sapiens
252 KRT81  
Two-hybrid Homo sapiens
253 TRMT61A 115708
Co-fractionation Homo sapiens
254 HNRNPK 3190
Co-fractionation Homo sapiens
255 SSBP1 6742
Co-fractionation Homo sapiens
256 ESR1  
Reconstituted Complex Homo sapiens
257 HAUS7  
Proximity Label-MS Homo sapiens
258 CCNI 10983
Two-hybrid Homo sapiens
259 TBK1 29110
Proximity Label-MS Homo sapiens
260 EFTUD1 79631
Co-fractionation Homo sapiens
261 KRT6C 286887
Two-hybrid Homo sapiens
262 XPO5 57510
Co-fractionation Homo sapiens
263 Fam83d  
Affinity Capture-MS Mus musculus
264 N4BP2  
Proximity Label-MS Homo sapiens
265 PIBF1  
Proximity Label-MS Homo sapiens
266 KRT20 54474
Cross-Linking-MS (XL-MS) Homo sapiens
267 SPAG5 10615
Proximity Label-MS Homo sapiens
268 INA 9118
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
269 RTCB 51493
Co-fractionation Homo sapiens
270 PLS3 5358
Co-fractionation Homo sapiens
271 HARS 3035
Co-fractionation Homo sapiens
272 C1orf109  
Two-hybrid Homo sapiens
273 BICD2 23299
Proximity Label-MS Homo sapiens
274 METTL3  
Affinity Capture-MS Homo sapiens
275 C14orf166 51637
Co-fractionation Homo sapiens
276 LDOC1  
Two-hybrid Homo sapiens
277 AIM1 202
Proximity Label-MS Homo sapiens
278 PDE4DIP 9659
Two-hybrid Homo sapiens
279 CUL7 9820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
280 KRAS 3845
Negative Genetic Homo sapiens
281 HNRNPU 3192
Co-fractionation Homo sapiens
282 AR 367
Affinity Capture-MS Homo sapiens
283 HAUS2  
Proximity Label-MS Homo sapiens
284 MYC  
Affinity Capture-MS Homo sapiens
285 NEFL 4747
Cross-Linking-MS (XL-MS) Homo sapiens
286 PTRF 284119
Proximity Label-MS Homo sapiens
287 VIM 7431
Proximity Label-MS Homo sapiens
288 RPA2 6118
Proximity Label-MS Homo sapiens
289 SMCHD1 23347
Cross-Linking-MS (XL-MS) Homo sapiens
290 CAV1 857
Proximity Label-MS Homo sapiens
291 NUP188 23511
Proximity Label-MS Homo sapiens
292 ANKHD1-EIF4EBP3  
Proximity Label-MS Homo sapiens
293 EP300 2033
Two-hybrid Homo sapiens
294 CDC5L 988
Two-hybrid Homo sapiens
295 SIPA1L3  
Proximity Label-MS Homo sapiens
296 CNDP2 55748
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which KRT18 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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