Gene description for MICAL3
Gene name microtubule associated monooxygenase, calponin and LIM domain containing 3
Gene symbol MICAL3
Other names/aliases MICAL-3
Species Homo sapiens
 Database cross references - MICAL3
ExoCarta ExoCarta_57553
Vesiclepedia VP_57553
Entrez Gene 57553
HGNC 24694
MIM 608882
UniProt Q7RTP6  
 MICAL3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MICAL3
Molecular Function
    actin binding GO:0003779 IDA
    actin binding GO:0003779 ISS
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 ISS
    metal ion binding GO:0046872 IEA
    molecular adaptor activity GO:0060090 EXP
    FAD binding GO:0071949 ISS
    F-actin monooxygenase activity GO:0120501 IEA
Biological Process
    exocytosis GO:0006887 IEA
    cytoskeleton organization GO:0007010 IDA
    actin filament depolymerization GO:0030042 IDA
    actin filament depolymerization GO:0030042 ISS
    cell division GO:0051301 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    spindle GO:0005819 IEA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    cell cortex GO:0005938 IEA
    cell projection GO:0042995 IEA
    intercellular bridge GO:0045171 IDA
    Flemming body GO:0090543 IDA
 Experiment description of studies that identified MICAL3 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MICAL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANLN 54443
Affinity Capture-MS Homo sapiens
2 LIG4 3981
Affinity Capture-MS Homo sapiens
3 RAB35 11021
Proximity Label-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 CSNK2B 1460
Affinity Capture-MS Homo sapiens
6 KIF14 9928
Affinity Capture-MS Homo sapiens
7 PSMD4 5710
Cross-Linking-MS (XL-MS) Homo sapiens
8 Myh9 17886
Affinity Capture-MS Mus musculus
9 Cd2ap 12488
Affinity Capture-MS Mus musculus
10 Racgap1 26934
Affinity Capture-MS Mus musculus
11 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RAB8B 51762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NINL  
Proximity Label-MS Homo sapiens
14 ECT2 1894
Affinity Capture-MS Homo sapiens
15 RACGAP1 29127
Affinity Capture-MS Homo sapiens
16 METTL7A 25840
Proximity Label-MS Homo sapiens
17 E2F4  
Affinity Capture-MS Homo sapiens
18 RAB11A 8766
Proximity Label-MS Homo sapiens
19 MYO18A 399687
Affinity Capture-MS Homo sapiens
20 ATP5A1 498
Cross-Linking-MS (XL-MS) Homo sapiens
21 Itga5 16402
Affinity Capture-MS Mus musculus
22 CAPZA2 830
Affinity Capture-MS Homo sapiens
23 CTDP1 9150
Affinity Capture-MS Homo sapiens
24 MYO19  
Affinity Capture-MS Homo sapiens
25 Mical3  
Affinity Capture-MS Mus musculus
26 Actb 11461
Affinity Capture-MS Mus musculus
27 STX4 6810
Proximity Label-MS Homo sapiens
28 C11orf52 91894
Proximity Label-MS Homo sapiens
29 OCLN 100506658
Proximity Label-MS Homo sapiens
30 LYN 4067
Proximity Label-MS Homo sapiens
31 PFN1 5216
Proximity Label-MS Homo sapiens
32 CHCHD4  
Affinity Capture-MS Homo sapiens
33 ANKAR  
Cross-Linking-MS (XL-MS) Homo sapiens
34 CAV1 857
Proximity Label-MS Homo sapiens
35 SEC62 7095
Proximity Label-MS Homo sapiens
36 MYH9 4627
Affinity Capture-MS Homo sapiens
37 BARD1 580
Affinity Capture-MS Homo sapiens
38 KIF23 9493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ACTR3 10096
Proximity Label-MS Homo sapiens
40 CERKL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 Flot1 14251
Affinity Capture-MS Mus musculus
42 EPHA2 1969
Proximity Label-MS Homo sapiens
43 CALD1 800
Cross-Linking-MS (XL-MS) Homo sapiens
44 SNX27 81609
Affinity Capture-MS Homo sapiens
45 ANK3  
Proximity Label-MS Homo sapiens
46 MDC1  
Affinity Capture-MS Homo sapiens
47 RHOB 388
Proximity Label-MS Homo sapiens
48 KRAS 3845
Proximity Label-MS Homo sapiens
49 SSR1 6745
Proximity Label-MS Homo sapiens
50 Shcbp1 20419
Affinity Capture-MS Mus musculus
51 PICALM 8301
Affinity Capture-MS Homo sapiens
52 CTDSPL 10217
Proximity Label-MS Homo sapiens
53 S100A2 6273
Affinity Capture-MS Homo sapiens
54 SEC61B 10952
Proximity Label-MS Homo sapiens
55 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 SNRPB 6628
Cross-Linking-MS (XL-MS) Homo sapiens
57 Kif23 71819
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which MICAL3 is involved
No pathways found





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