Gene description for SRPK1
Gene name SRSF protein kinase 1
Gene symbol SRPK1
Other names/aliases SFRSK1
Species Homo sapiens
 Database cross references - SRPK1
ExoCarta ExoCarta_6732
Vesiclepedia VP_6732
Entrez Gene 6732
HGNC 11305
MIM 601939
UniProt Q96SB4  
 SRPK1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Hepatocytes 26054723    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for SRPK1
Molecular Function
    magnesium ion binding GO:0000287 IDA
    RNA binding GO:0003723 HDA
    protein kinase activity GO:0004672 TAS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    spliceosomal complex assembly GO:0000245 IBA
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    chromosome segregation GO:0007059 IDA
    RNA splicing GO:0008380 TAS
    sperm DNA condensation GO:0035092 TAS
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 IDA
    positive regulation of viral genome replication GO:0045070 IDA
    negative regulation of viral genome replication GO:0045071 IDA
    innate immune response GO:0045087 IC
    regulation of mRNA splicing, via spliceosome GO:0048024 TAS
    regulation of mRNA processing GO:0050684 IBA
    regulation of mRNA processing GO:0050684 IDA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    nuclear matrix GO:0016363 IEA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified SRPK1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
17
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SRPK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
Co-fractionation Homo sapiens
2 ZBTB38 253461
Affinity Capture-MS Homo sapiens
3 SNRPA 6626
Affinity Capture-MS Homo sapiens
4 SPATS2  
Biochemical Activity Homo sapiens
5 ARHGAP26 23092
Biochemical Activity Homo sapiens
6 MCM7 4176
Co-fractionation Homo sapiens
7 UBE2H 7328
Affinity Capture-MS Homo sapiens
8 HNRNPC 3183
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
9 ISG15 9636
Affinity Capture-MS Homo sapiens
10 RBMS2 5939
Biochemical Activity Homo sapiens
11 ZNF514  
Biochemical Activity Homo sapiens
12 DNAJC9 23234
Proximity Label-MS Homo sapiens
13 ALKBH3  
Biochemical Activity Homo sapiens
14 PAXIP1  
Affinity Capture-MS Homo sapiens
15 RPS6KB2  
Biochemical Activity Homo sapiens
16 DDX47 51202
Biochemical Activity Homo sapiens
17 PRPF8 10594
Co-fractionation Homo sapiens
18 SRPK2 6733
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
19 PDGFRA 5156
Biochemical Activity Homo sapiens
20 TARDBP 23435
Affinity Capture-MS Homo sapiens
21 GABARAPL1 23710
Biochemical Activity Homo sapiens
22 C18orf25 147339
Biochemical Activity Homo sapiens
23 PRPF38A 84950
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
24 RPL13A 23521
Affinity Capture-MS Homo sapiens
25 HIRIP3  
Biochemical Activity Homo sapiens
26 DHX8 1659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
27 ARL6IP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
28 RPL15 6138
Affinity Capture-MS Homo sapiens
29 ZNF444  
Biochemical Activity Homo sapiens
30 ARCN1 372
Co-fractionation Homo sapiens
31 CHEK2  
Biochemical Activity Homo sapiens
32 KPNA2 3838
Biochemical Activity Homo sapiens
33 CAND1 55832
Affinity Capture-MS Homo sapiens
34 EPB41L4A 64097
Biochemical Activity Homo sapiens
35 OCEL1  
Biochemical Activity Homo sapiens
36 SRSF2 6427
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
37 SNRPF 6636
Affinity Capture-MS Homo sapiens
38 SNRPD2 6633
Affinity Capture-MS Homo sapiens
39 APP 351
Reconstituted Complex Homo sapiens
40 MBNL3  
Biochemical Activity Homo sapiens
41 GSK3A 2931
Affinity Capture-MS Homo sapiens
42 USP36  
Affinity Capture-MS Homo sapiens
43 SPANXN4  
Biochemical Activity Homo sapiens
44 LAMC1 3915
Biochemical Activity Homo sapiens
45 DDX23 9416
Proximity Label-MS Homo sapiens
46 PARK2  
Affinity Capture-MS Homo sapiens
47 MAOB  
Two-hybrid Homo sapiens
48 DROSHA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SNRNP70 6625
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
50 RNPS1 10921
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
51 RBM23  
Biochemical Activity Homo sapiens
52 POLR2E 5434
Biochemical Activity Homo sapiens
53 PELI1 57162
Biochemical Activity Homo sapiens
54 DYRK1A 1859
Affinity Capture-MS Homo sapiens
55 TGFB1 7040
Affinity Capture-MS Homo sapiens
56 KIF23 9493
Affinity Capture-MS Homo sapiens
57 RIMS4  
Biochemical Activity Homo sapiens
58 ADPRH 141
Biochemical Activity Homo sapiens
59 USP39 10713
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
60 COPB2 9276
Co-fractionation Homo sapiens
61 ESRRG  
Biochemical Activity Homo sapiens
62 COPS5 10987
Affinity Capture-MS Homo sapiens
63 FBXW7  
Affinity Capture-MS Homo sapiens
64 CHERP 10523
Biochemical Activity Homo sapiens
65 IQGAP1 8826
Affinity Capture-MS Homo sapiens
66 NOL4L  
Biochemical Activity Homo sapiens
67 NPM1 4869
Affinity Capture-MS Homo sapiens
68 SRRM2 23524
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 SNRPC 6631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 ZMYND11 10771
Biochemical Activity Homo sapiens
71 FBL 2091
Proximity Label-MS Homo sapiens
72 MAPK14 1432
Biochemical Activity Homo sapiens
73 SRP19 6728
Affinity Capture-MS Homo sapiens
74 C11orf52 91894
Biochemical Activity Homo sapiens
75 PSMC2 5701
Co-fractionation Homo sapiens
76 TFEB  
Biochemical Activity Homo sapiens
77 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
78 ADARB1 104
Affinity Capture-MS Homo sapiens
79 KCNN2  
Biochemical Activity Homo sapiens
80 PRKRA 8575
Affinity Capture-MS Homo sapiens
81 CDK7 1022
Biochemical Activity Homo sapiens
82 ILF3 3609
Affinity Capture-MS Homo sapiens
83 SNRPD3 6634
Affinity Capture-MS Homo sapiens
84 SRP68 6730
Affinity Capture-MS Homo sapiens
85 U2AF1 7307
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
86 PHF7  
Biochemical Activity Homo sapiens
87 LIMK1 3984
Biochemical Activity Homo sapiens
88 NOP16 51491
Biochemical Activity Homo sapiens
89 KPTN  
Biochemical Activity Homo sapiens
90 SLC4A1AP  
Biochemical Activity Homo sapiens
91 MYCN  
Affinity Capture-MS Homo sapiens
92 RBM42  
Affinity Capture-MS Homo sapiens
93 RIOK2 55781
Affinity Capture-MS Homo sapiens
94 ERBB2 2064
Biochemical Activity Homo sapiens
95 SREK1 140890
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
96 RBM8A 9939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
97 KIF14 9928
Affinity Capture-MS Homo sapiens
98 ACIN1 22985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 AURKC  
Biochemical Activity Homo sapiens
100 CHTOP  
Affinity Capture-MS Homo sapiens
101 PAK4 10298
Biochemical Activity Homo sapiens
102 DAW1  
Biochemical Activity Homo sapiens
103 PFN1 5216
Biochemical Activity Homo sapiens
104 AURKA 6790
Biochemical Activity Homo sapiens
105 SRP9 6726
Affinity Capture-MS Homo sapiens
106 ARHGAP12  
Biochemical Activity Homo sapiens
107 CLK4  
Biochemical Activity Homo sapiens
108 C11orf63  
Biochemical Activity Homo sapiens
109 FOXA1  
Affinity Capture-MS Homo sapiens
110 Gtf3c4  
Affinity Capture-MS Mus musculus
111 COX15 1355
Affinity Capture-MS Homo sapiens
112 MAPK12  
Biochemical Activity Homo sapiens
113 NSG1  
Affinity Capture-MS Homo sapiens
114 SLAIN2  
Biochemical Activity Homo sapiens
115 RPL4 6124
Affinity Capture-MS Homo sapiens
116 PPIL1 51645
Biochemical Activity Homo sapiens
117 DRG1 4733
Affinity Capture-MS Homo sapiens
118 TAF1B  
Biochemical Activity Homo sapiens
119 SRSF3 6428
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
120 HELLS 3070
Affinity Capture-MS Homo sapiens
121 DNAJC2 27000
Affinity Capture-MS Homo sapiens
122 STAU1 6780
Biochemical Activity Homo sapiens
123 RSRC2  
Biochemical Activity Homo sapiens
124 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
125 SRSF6 6431
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
126 PURG  
Affinity Capture-MS Homo sapiens
127 NOP2 4839
Co-fractionation Homo sapiens
128 MAP1LC3A 84557
Biochemical Activity Homo sapiens
129 MRPS11  
Biochemical Activity Homo sapiens
130 RPL5 6125
Affinity Capture-MS Homo sapiens
131 AKR7L 246181
Affinity Capture-MS Homo sapiens
132 LCE3D  
Biochemical Activity Homo sapiens
133 MAPT  
Reconstituted Complex Homo sapiens
134 PABPC1 26986
Affinity Capture-MS Homo sapiens
135 FLT1 2321
Biochemical Activity Homo sapiens
136 NELFE 7936
Biochemical Activity Homo sapiens
137 FAM124A  
Biochemical Activity Homo sapiens
138 BARD1 580
Affinity Capture-MS Homo sapiens
139 DDX5 1655
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
140 NTRK1 4914
Affinity Capture-MS Homo sapiens
141 RPL31 6160
Proximity Label-MS Homo sapiens
142 FGF12  
Biochemical Activity Homo sapiens
143 CBX5 23468
Biochemical Activity Homo sapiens
144 LRPAP1 4043
Affinity Capture-MS Homo sapiens
145 U2AF2 11338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 RAD18  
Affinity Capture-MS Homo sapiens
147 UBE2E2  
Biochemical Activity Homo sapiens
148 NCL 4691
Affinity Capture-MS Homo sapiens
149 LUC7L2 51631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
150 FBXL6  
Affinity Capture-MS Homo sapiens
151 TNFRSF10C  
Biochemical Activity Homo sapiens
152 RPS6 6194
Affinity Capture-MS Homo sapiens
153 ZRSR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
154 MAGOH 4116
Affinity Capture-MS Homo sapiens
155 RPLP0 6175
Affinity Capture-MS Homo sapiens
156 NKAP 79576
Biochemical Activity Homo sapiens
157 SRPK3  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
158 MAGEB2 4113
Affinity Capture-MS Homo sapiens
159 SETD3 84193
Biochemical Activity Homo sapiens
160 H2AFY 9555
Biochemical Activity Homo sapiens
161 PPM1G 5496
Co-fractionation Homo sapiens
162 Ksr1  
Affinity Capture-MS Mus musculus
163 MYC  
Affinity Capture-MS Homo sapiens
164 SF3A3 10946
Co-fractionation Homo sapiens
165 CDKL3  
Biochemical Activity Homo sapiens
166 YPEL2 388403
Biochemical Activity Homo sapiens
167 GABARAP 11337
Biochemical Activity Homo sapiens
168 LARP1 23367
Biochemical Activity Homo sapiens
169 HMGN3  
Biochemical Activity Homo sapiens
170 BCLAF1 9774
Affinity Capture-MS Homo sapiens
171 FGFBP1 9982
Affinity Capture-MS Homo sapiens
172 SRSF11 9295
Affinity Capture-MS Homo sapiens
173 C9orf72  
Biochemical Activity Homo sapiens
174 FAM76B  
Biochemical Activity Homo sapiens
175 ZBTB2 57621
Affinity Capture-MS Homo sapiens
176 RBM39 9584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
177 SERPINB10  
Biochemical Activity Homo sapiens
178 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 HIST1H3A 8350
Proximity Label-MS Homo sapiens
180 Myh9 17886
Affinity Capture-MS Mus musculus
181 HBS1L 10767
Biochemical Activity Homo sapiens
182 RSRP1  
Biochemical Activity Homo sapiens
183 AHCYL1 10768
Biochemical Activity Homo sapiens
184 CIAO1 9391
Biochemical Activity Homo sapiens
185 RC3H2  
Affinity Capture-MS Homo sapiens
186 ECT2 1894
Affinity Capture-MS Homo sapiens
187 YBX3 8531
Affinity Capture-MS Homo sapiens
188 SIRT7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 ODF3L2  
Biochemical Activity Homo sapiens
190 SNRPB 6628
Affinity Capture-MS Homo sapiens
191 ASAH1 427
Biochemical Activity Homo sapiens
192 YAF2  
Affinity Capture-MS Homo sapiens
193 SRSF1 6426
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
194 MAGEB1  
Biochemical Activity Homo sapiens
195 EIF4A3 9775
Affinity Capture-MS Homo sapiens
196 RPL37 6167
Affinity Capture-MS Homo sapiens
197 NAT10 55226
Co-fractionation Homo sapiens
198 RPL3 6122
Affinity Capture-MS Homo sapiens
199 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
200 Rrbp1  
Affinity Capture-MS Mus musculus
201 WDR55  
Biochemical Activity Homo sapiens
202 PELI2 57161
Biochemical Activity Homo sapiens
203 CRHR1  
Biochemical Activity Homo sapiens
204 C11orf87  
Biochemical Activity Homo sapiens
205 HNRNPA1 3178
Biochemical Activity Homo sapiens
206 PPIA 5478
Biochemical Activity Homo sapiens
207 RBM27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 Ncaph  
Affinity Capture-MS Mus musculus
209 CACNB1  
Biochemical Activity Homo sapiens
210 NSRP1  
Biochemical Activity Homo sapiens
211 LINC00312  
Biochemical Activity Homo sapiens
212 SART1 9092
Co-fractionation Homo sapiens
213 DUSP6 1848
Biochemical Activity Homo sapiens
214 YTHDC1  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
215 RBMX2  
Affinity Capture-MS Homo sapiens
216 SUDS3  
Biochemical Activity Homo sapiens
217 SRSF8 10929
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
218 MAP2K3 5606
Affinity Capture-MS Homo sapiens
219 RPL36 25873
Affinity Capture-MS Homo sapiens
220 PCBP1 5093
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
221 PRM1  
Biochemical Activity Homo sapiens
222 PTK2 5747
Biochemical Activity Homo sapiens
223 PSPC1 55269
Affinity Capture-MS Homo sapiens
224 HECW2  
Affinity Capture-MS Homo sapiens
225 CLK1  
Biochemical Activity Homo sapiens
226 NOVA1  
Biochemical Activity Homo sapiens
227 FUS 2521
Affinity Capture-MS Homo sapiens
228 INO80B 83444
Affinity Capture-MS Homo sapiens
229 RPS14 6208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
230 MAPKAPK5 8550
Biochemical Activity Homo sapiens
231 TOP1 7150
Affinity Capture-MS Homo sapiens
232 ZNF653  
Affinity Capture-MS Homo sapiens
233 CSAG1  
Biochemical Activity Homo sapiens
234 OR6B3  
Biochemical Activity Homo sapiens
235 AMMECR1L 83607
Biochemical Activity Homo sapiens
236 FKBP3 2287
Biochemical Activity Homo sapiens
237 DDRGK1 65992
Affinity Capture-MS Homo sapiens
238 PDPK1 5170
Biochemical Activity Homo sapiens
239 NSMCE4A  
Biochemical Activity Homo sapiens
240 CAMK2D 817
Biochemical Activity Homo sapiens
241 ARGLU1  
Biochemical Activity Homo sapiens
242 H2AFB2  
Affinity Capture-MS Homo sapiens
243 KIAA1841 84542
Biochemical Activity Homo sapiens
244 ASXL1  
Biochemical Activity Homo sapiens
245 TJP2 9414
Affinity Capture-MS Homo sapiens
246 Eif3e 16341
Affinity Capture-MS Mus musculus
247 BMP4 652
Affinity Capture-MS Homo sapiens
248 CHUK 1147
Biochemical Activity Homo sapiens
249 WIBG 84305
Affinity Capture-MS Homo sapiens
250 ECM1 1893
Biochemical Activity Homo sapiens
251 SFMBT1 51460
Biochemical Activity Homo sapiens
252 FLOT1 10211
Biochemical Activity Homo sapiens
253 SOX2  
Affinity Capture-MS Homo sapiens
254 HECTD1 25831
Affinity Capture-MS Homo sapiens
255 RPS16 6217
Affinity Capture-MS Homo sapiens
256 AHSA1 10598
Affinity Capture-Western Homo sapiens
257 RPL13 6137
Affinity Capture-MS Homo sapiens
258 DHX15 1665
Co-fractionation Homo sapiens
259 GRK5 2869
Affinity Capture-MS Homo sapiens
260 NUDT21 11051
Biochemical Activity Homo sapiens
261 FHL1 2273
Biochemical Activity Homo sapiens
262 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
263 HNRNPDL 9987
Co-fractionation Homo sapiens
264 RC3H1 149041
Affinity Capture-MS Homo sapiens
265 VDR  
Biochemical Activity Homo sapiens
266 CLIC5 53405
Biochemical Activity Homo sapiens
267 HDGF 3068
Affinity Capture-MS Homo sapiens
268 ZRANB2 9406
Biochemical Activity Homo sapiens
269 CPSF6 11052
Affinity Capture-MS Homo sapiens
270 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
271 WWOX 51741
Affinity Capture-MS Homo sapiens
272 PEX19 5824
Two-hybrid Homo sapiens
273 CDC42EP3 10602
Biochemical Activity Homo sapiens
274 DDX3X 1654
Co-fractionation Homo sapiens
275 APEX1 328
Biochemical Activity Homo sapiens
276 SON 6651
Affinity Capture-MS Homo sapiens
277 MRPL43 84545
Biochemical Activity Homo sapiens
278 IKBKG 8517
Reconstituted Complex Homo sapiens
279 DGCR8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
280 TRIM65 201292
Biochemical Activity Homo sapiens
281 HNRNPM 4670
Affinity Capture-MS Homo sapiens
282 SMURF1 57154
Affinity Capture-MS Homo sapiens
283 THRAP3 9967
Affinity Capture-MS Homo sapiens
284 C1orf35  
Affinity Capture-MS Homo sapiens
285 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
286 STK26 51765
Biochemical Activity Homo sapiens
287 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
288 PUF60 22827
Affinity Capture-MS Homo sapiens
289 TRA2B 6434
Biochemical Activity Homo sapiens
290 UBD  
Biochemical Activity Homo sapiens
291 MKI67  
Affinity Capture-MS Homo sapiens
292 MAP2K1 5604
Affinity Capture-MS Homo sapiens
293 NCK2 8440
Biochemical Activity Homo sapiens
294 TOP2A 7153
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
295 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
296 UFL1 23376
Affinity Capture-MS Homo sapiens
297 EPHA3 2042
Biochemical Activity Homo sapiens
298 KRR1 11103
Biochemical Activity Homo sapiens
299 C16orf78  
Biochemical Activity Homo sapiens
300 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
301 PPIG 9360
Affinity Capture-MS Homo sapiens
302 RSRC1  
Biochemical Activity Homo sapiens
303 API5 8539
Affinity Capture-MS Homo sapiens
304 ALYREF 10189
Affinity Capture-MS Homo sapiens
305 EIF3M 10480
Biochemical Activity Homo sapiens
306 LRRK2 120892
Affinity Capture-MS Homo sapiens
307 TRIP4 9325
Affinity Capture-MS Homo sapiens
308 NXT2  
Biochemical Activity Homo sapiens
309 SRSF7 6432
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
310 KCNAB1  
Biochemical Activity Homo sapiens
311 DNAJC8 22826
Biochemical Activity Homo sapiens
312 CIT 11113
Affinity Capture-MS Homo sapiens
313 SAFB 6294
Two-hybrid Homo sapiens
314 SEC23B 10483
Biochemical Activity Homo sapiens
315 RPL28 6158
Affinity Capture-MS Homo sapiens
316 KRAS 3845
Affinity Capture-MS Homo sapiens
317 GNB2L1 10399
Affinity Capture-MS Homo sapiens
318 EWSR1 2130
Affinity Capture-MS Homo sapiens
319 RBM34  
Affinity Capture-MS Homo sapiens
320 VANGL1 81839
Biochemical Activity Homo sapiens
321 SSRP1 6749
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
322 RPA3 6119
Proximity Label-MS Homo sapiens
323 LUC7L 55692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
324 SRSF12  
Biochemical Activity Homo sapiens
325 LUC7L3 51747
Biochemical Activity Homo sapiens
326 RPL17 6139
Affinity Capture-MS Homo sapiens
327 EP300 2033
Affinity Capture-MS Homo sapiens
328 IFIT5 24138
Biochemical Activity Homo sapiens
329 PNN 5411
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here