Gene description for MRPL43
Gene name mitochondrial ribosomal protein L43
Gene symbol MRPL43
Other names/aliases L43mt
MRP-L43
bMRP36a
Species Homo sapiens
 Database cross references - MRPL43
ExoCarta ExoCarta_84545
Vesiclepedia VP_84545
Entrez Gene 84545
HGNC 14517
MIM 611848
UniProt Q8N983  
 MRPL43 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MRPL43
Molecular Function
    RNA binding GO:0003723 HDA
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 NAS
    protein binding GO:0005515 IPI
Biological Process
    translation GO:0006412 NAS
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial ribosome GO:0005761 NAS
    mitochondrial large ribosomal subunit GO:0005762 IBA
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
 Experiment description of studies that identified MRPL43 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MRPL43
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 SLIRP 81892
Proximity Label-MS Homo sapiens
3 MRPL30  
Affinity Capture-MS Homo sapiens
4 Ybx1 22608
Affinity Capture-MS Mus musculus
5 MTG2  
Proximity Label-MS Homo sapiens
6 NGRN  
Proximity Label-MS Homo sapiens
7 RPL10 6134
Affinity Capture-MS Homo sapiens
8 CHCHD1  
Proximity Label-MS Homo sapiens
9 MRPL10 124995
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MRPL27 51264
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MRPL50 54534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CAND1 55832
Affinity Capture-MS Homo sapiens
13 MRPL52  
Affinity Capture-MS Homo sapiens
14 RPUSD4 84881
Proximity Label-MS Homo sapiens
15 DIEXF  
Affinity Capture-MS Homo sapiens
16 DNAJC15  
Proximity Label-MS Homo sapiens
17 MTRF1  
Proximity Label-MS Homo sapiens
18 GFM2 84340
Proximity Label-MS Homo sapiens
19 CCDC90B  
Proximity Label-MS Homo sapiens
20 LRPPRC 10128
Proximity Label-MS Homo sapiens
21 RPS18 6222
Co-fractionation Homo sapiens
22 MRPL20 55052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MCU 90550
Proximity Label-MS Homo sapiens
24 CRYZ 1429
Proximity Label-MS Homo sapiens
25 TFAM 7019
Proximity Label-MS Homo sapiens
26 PMPCA 23203
Proximity Label-MS Homo sapiens
27 MRPL23 6150
Affinity Capture-MS Homo sapiens
28 COPS5 10987
Affinity Capture-MS Homo sapiens
29 HINT2 84681
Proximity Label-MS Homo sapiens
30 MRPL12 6182
Affinity Capture-MS Homo sapiens
31 KLF15  
Affinity Capture-MS Homo sapiens
32 MRPS26 64949
Proximity Label-MS Homo sapiens
33 MALSU1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LAMTOR3 8649
Co-fractionation Homo sapiens
35 EXD2  
Proximity Label-MS Homo sapiens
36 RC3H1 149041
Affinity Capture-MS Homo sapiens
37 ITGA4 3676
Affinity Capture-MS Homo sapiens
38 MRPL39 54148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 VCAM1 7412
Affinity Capture-MS Homo sapiens
40 NAP1L4 4676
Affinity Capture-MS Homo sapiens
41 PMPCB 9512
Proximity Label-MS Homo sapiens
42 TACO1  
Proximity Label-MS Homo sapiens
43 FASTKD2  
Proximity Label-MS Homo sapiens
44 VWA8 23078
Proximity Label-MS Homo sapiens
45 MRPL47 57129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
46 RPL19 6143
Affinity Capture-MS Homo sapiens
47 MTERF3  
Proximity Label-MS Homo sapiens
48 Erp44 76299
Affinity Capture-MS Mus musculus
49 MDH2 4191
Proximity Label-MS Homo sapiens
50 MRPS30 10884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 E2F4  
Affinity Capture-MS Homo sapiens
52 MRPL13  
Affinity Capture-MS Homo sapiens
53 C6orf203  
Proximity Label-MS Homo sapiens
54 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 FASTKD5  
Proximity Label-MS Homo sapiens
56 YBX2 51087
Affinity Capture-MS Homo sapiens
57 TUFM 7284
Proximity Label-MS Homo sapiens
58 HSCB 150274
Proximity Label-MS Homo sapiens
59 NDUFAF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 MRPL37 51253
Affinity Capture-MS Homo sapiens
61 RBMS2 5939
Affinity Capture-MS Homo sapiens
62 CCDC109B 55013
Proximity Label-MS Homo sapiens
63 NDUFA2 4695
Co-fractionation Homo sapiens
64 TRUB2  
Proximity Label-MS Homo sapiens
65 MRPL11 65003
Proximity Label-MS Homo sapiens
66 MTRF1L  
Proximity Label-MS Homo sapiens
67 TMEM70  
Proximity Label-MS Homo sapiens
68 CYLD  
Affinity Capture-MS Homo sapiens
69 SRPK1 6732
Biochemical Activity Homo sapiens
70 MRPL2 51069
Affinity Capture-MS Homo sapiens
71 COX4I1 1327
Proximity Label-MS Homo sapiens
72 Brwd3  
Affinity Capture-MS Mus musculus
73 MRPL44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 MRPL51 51258
Affinity Capture-MS Homo sapiens
75 MRPL40 64976
Co-fractionation Homo sapiens
76 MRPL21 219927
Affinity Capture-MS Homo sapiens
77 MRRF  
Proximity Label-MS Homo sapiens
78 MRPS12  
Proximity Label-MS Homo sapiens
79 MTIF2 4528
Proximity Label-MS Homo sapiens
80 RC3H2  
Affinity Capture-MS Homo sapiens
81 MTIF3  
Proximity Label-MS Homo sapiens
82 MRPL9 65005
Affinity Capture-MS Homo sapiens
83 RPL37 6167
Affinity Capture-MS Homo sapiens
84 GLS 2744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 EGFR 1956
Affinity Capture-MS Homo sapiens
86 GADD45GIP1  
Affinity Capture-MS Homo sapiens
87 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
88 DHX30 22907
Proximity Label-MS Homo sapiens
89 NACC1 112939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 C17orf80 55028
Proximity Label-MS Homo sapiens
91 MRPL15 29088
Affinity Capture-MS Homo sapiens
92 C12orf65  
Proximity Label-MS Homo sapiens
93 MYCN  
Affinity Capture-MS Homo sapiens
94 MRPL19 9801
Affinity Capture-MS Homo sapiens
95 MTG1  
Proximity Label-MS Homo sapiens
96 MYC  
Affinity Capture-MS Homo sapiens
97 FXR2 9513
Two-hybrid Homo sapiens
98 AKAP5  
Affinity Capture-MS Homo sapiens
99 ACAD9 28976
Proximity Label-MS Homo sapiens
100 MRPL38  
Affinity Capture-MS Homo sapiens
101 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
102 METTL15  
Proximity Label-MS Homo sapiens
103 MRPL18 29074
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 HUWE1 10075
Affinity Capture-MS Homo sapiens
105 CLPP 8192
Proximity Label-MS Homo sapiens
106 CS 1431
Proximity Label-MS Homo sapiens
107 MRPL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 ARRB2 409
Affinity Capture-MS Homo sapiens
109 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
110 TSFM 10102
Proximity Label-MS Homo sapiens
111 AUH 549
Proximity Label-MS Homo sapiens
112 TBRG4 9238
Proximity Label-MS Homo sapiens
113 DNAJC19 131118
Proximity Label-MS Homo sapiens
114 SLK 9748
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
116 LONP1 9361
Proximity Label-MS Homo sapiens
117 MRPL53  
Affinity Capture-MS Homo sapiens
118 DNAJA3 9093
Proximity Label-MS Homo sapiens
119 MRPL1  
Affinity Capture-MS Homo sapiens
120 C21orf33  
Proximity Label-MS Homo sapiens
121 SSBP1 6742
Proximity Label-MS Homo sapiens
122 FASTKD3  
Proximity Label-MS Homo sapiens
123 GFM1 85476
Proximity Label-MS Homo sapiens
124 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 GRSF1 2926
Proximity Label-MS Homo sapiens
126 C1QBP 708
Proximity Label-MS Homo sapiens
127 KRAS 3845
Negative Genetic Homo sapiens
128 METTL17  
Proximity Label-MS Homo sapiens
129 MRPL28 10573
Affinity Capture-MS Homo sapiens
130 DDX56  
Affinity Capture-MS Homo sapiens
131 DDX28  
Proximity Label-MS Homo sapiens
132 CASQ2 845
Affinity Capture-MS Homo sapiens
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