ExoCarta: Gene summary

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Gene description for HERC2
Gene name	HECT and RLD domain containing E3 ubiquitin protein ligase 2
Gene symbol	HERC2
Other names/aliases	D15F37S1 MRT38 SHEP1 jdf2 p528
Species	Homo sapiens
Database cross references - HERC2
ExoCarta	ExoCarta_8924
Vesiclepedia	VP_8924
Entrez Gene	8924
HGNC	4868
MIM	605837
UniProt	O95714
HERC2 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894
Mesenchymal stem cells	36408942

Gene ontology annotations for HERC2

Molecular Function
	guanyl-nucleotide exchange factor activity	GO:0005085	NAS
	protein binding	GO:0005515	IPI
	zinc ion binding	GO:0008270	IEA
	ubiquitin protein ligase binding	GO:0031625	IPI
	SUMO binding	GO:0032183	IDA
	ubiquitin protein ligase activity	GO:0061630	IBA
	ubiquitin protein ligase activity	GO:0061630	IDA
Biological Process
	DNA repair	GO:0006281	IEA
	intracellular protein transport	GO:0006886	NAS
	DNA damage response	GO:0006974	IDA
	spermatogenesis	GO:0007283	IEA
	protein ubiquitination	GO:0016567	IBA
	protein ubiquitination	GO:0016567	IDA
	protein ubiquitination	GO:0016567	IEA
	neuron differentiation	GO:0030182	IEA
	proteasome-mediated ubiquitin-dependent protein catabolic process	GO:0043161	IEA
	negative regulation of Notch signaling pathway	GO:0045746	IEA
Subcellular Localization
	nucleus	GO:0005634	IDA
	nucleoplasm	GO:0005654	TAS
	cytoplasm	GO:0005737	IBA
	cytoplasm	GO:0005737	IDA
	centriole	GO:0005814	IEA
	cytosol	GO:0005829	IDA
	plasma membrane	GO:0005886	IDA
	membrane	GO:0016020	HDA
	membrane	GO:0016020	IBA

Experiment description of studies that identified HERC2 in sEVs

Experiment ID

226

MISEV standards
✔ EM	Biophysical techniques
✔ GAPDH\|CD9\|FLOT1	Enriched markers
✔ LMNA\|H2AFX\|ATP5A1\|TOMM20	Negative markers
✘	Particle analysis

Identified molecule

mRNA

Identification method

Small RNA sequencing (Illumina HiSeq 2000 (Solexa)

PubMed ID

26027894

Organism

Homo sapiens

Experiment description

"Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"

Authors

"Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"

Journal name

Journal of Extracellular Vesicles

Publication year

2015

Sample

Endothelial cells

Sample name

HMEC-1

Isolation/purification methods

Differential ultracentrifugation
Sucrose density gradient

Flotation density

1.10 g/mL

Molecules identified in the study

miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA

Methods used in the study

Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting

Experiment ID

488

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD81\|CD63\|GAPDH\|SDCBP\|LAMP1\|TFRC\|UCHL1\|FLOT2\|LAMP2\|FLOT1\|ICAM1\|RAB5B\|CD151\|RAB35\|TSG101\|RAB5A\|CD82	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Homo sapiens

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Mesenchymal stem cells

Sample name

UCMSC

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for HERC2

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

Kif19a

Affinity Capture-MS

Mus musculus

EIF3A

8661

Affinity Capture-MS

Homo sapiens

SLFN11

91607

Affinity Capture-MS

Homo sapiens

UBE2H

7328

Affinity Capture-MS

Homo sapiens

CCDC151

Affinity Capture-MS

Homo sapiens

C5AR2

Two-hybrid

Homo sapiens

NUF2

Affinity Capture-MS

Homo sapiens

BIRC6

57448

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HOOK1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FAM98A

25940

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NPRL2

Affinity Capture-Western

Homo sapiens

PMS1

Affinity Capture-Western

Homo sapiens

AIPL1

Affinity Capture-MS

Homo sapiens

ZNF286A

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

EIF3C

8663

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MRPL30

Affinity Capture-MS

Homo sapiens

EIF3K

27335

Affinity Capture-MS

Homo sapiens

KIFC3

3801

Affinity Capture-MS

Homo sapiens

RPA2

6118

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

SERPINB6

5269

Cross-Linking-MS (XL-MS)

Homo sapiens

BRCA1

672

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

XPA

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Biochemical Activity		Homo sapiens

KIF20A

10112

Affinity Capture-MS

Homo sapiens

MRPL10

124995

Affinity Capture-MS

Homo sapiens

USP16

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

UBC

7316

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

LAMP2

3920

Proximity Label-MS

Homo sapiens

CALM1

801

Reconstituted Complex

Homo sapiens

PSMD10

5716

Affinity Capture-MS

Homo sapiens

APBB1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RIPK1

8737

Affinity Capture-MS

Homo sapiens

CCDC65

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RMI1

Affinity Capture-MS

Homo sapiens

LGALS3BP

3959

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GCG

Affinity Capture-MS

Homo sapiens

PPL

5493

Affinity Capture-MS

Homo sapiens

MRFAP1L1

Affinity Capture-MS

Homo sapiens

MARK2

2011

Affinity Capture-MS

Homo sapiens

Eef1a1

13627

Affinity Capture-MS

Mus musculus

B3GNT2

10678

Affinity Capture-MS

Homo sapiens

RNF8

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

EIF3B

8662

Affinity Capture-MS

Homo sapiens

Cep170

Affinity Capture-MS		Mus musculus
Affinity Capture-MS		Mus musculus

MRPL12

6182

Affinity Capture-MS

Homo sapiens

MDC1

Affinity Capture-Western

Homo sapiens

Ankrd26

Affinity Capture-MS

Mus musculus

ETFA

2108

Co-fractionation

Homo sapiens

SOST

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RAB5B

5869

Affinity Capture-Western

Homo sapiens

ZNF451

26036

Affinity Capture-MS

Homo sapiens

RAB5A

5868

Affinity Capture-Western

Homo sapiens

HERC2

8924

Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens

BRD4

23476

Affinity Capture-MS

Homo sapiens

UCHL5

51377

Affinity Capture-MS

Homo sapiens

DNAJC7

7266

Proximity Label-MS

Homo sapiens

RMI2

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

GTSE1

51512

Affinity Capture-MS

Homo sapiens

SGOL1

Affinity Capture-MS

Homo sapiens

CTNNA1

1495

Proximity Label-MS

Homo sapiens

GSK3B

2932

Affinity Capture-MS

Homo sapiens

FBXL5

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

MRPS30

10884

Affinity Capture-MS

Homo sapiens

AURKA

6790

Affinity Capture-MS

Homo sapiens

INPP4A

3631

Co-fractionation

Homo sapiens

PSMC2

5701

Affinity Capture-MS

Homo sapiens

DNAJB8

165721

Proximity Label-MS

Homo sapiens

DBNL

28988

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RB1CC1

9821

Affinity Capture-MS

Homo sapiens

PIAS4

Affinity Capture-Western

Homo sapiens

RABEP1

9135

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HSP90B1

7184

Cross-Linking-MS (XL-MS)

Homo sapiens

BLM

641

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

PSMC1

5700

Affinity Capture-MS

Homo sapiens

MAPRE1

22919

Affinity Capture-MS

Homo sapiens

PSMD14

10213

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

RNF115

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

EIF3E

3646

Affinity Capture-MS

Homo sapiens

KIF2B

84643

Affinity Capture-MS

Homo sapiens

CHMP4B

128866

Affinity Capture-MS

Homo sapiens

PSMD2

5708

Affinity Capture-MS

Homo sapiens

BARD1

580

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

RNF168

Affinity Capture-Western

Homo sapiens

RNF166

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NAT10

55226

Affinity Capture-MS

Homo sapiens

PNMA2

Affinity Capture-MS

Homo sapiens

DNAJA1

3301

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BICD2

23299

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MPDU1

9526

Affinity Capture-MS

Homo sapiens

FEZF1

Affinity Capture-MS

Homo sapiens

KRT2

3849

Affinity Capture-MS

Homo sapiens

Tnks2

Affinity Capture-MS

Mus musculus

HECTD1

25831

Affinity Capture-MS

Homo sapiens

GRIN2A

Affinity Capture-MS

Homo sapiens

EIF3H

8667

Affinity Capture-MS

Homo sapiens

DNAJB5

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GET4

51608

Affinity Capture-MS

Homo sapiens

RYBP

Affinity Capture-MS

Homo sapiens

NCOA4

8031

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

NEURL4

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

100

TUBB4B

10383

Affinity Capture-MS

Homo sapiens

101

DISC1

27185

Affinity Capture-MS

Homo sapiens

102

ECH1

1891

Affinity Capture-MS

Homo sapiens

103

EIF3G

8666

Affinity Capture-MS

Homo sapiens

104

UBE2N

7334

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

105

HSP90B2P

Cross-Linking-MS (XL-MS)

Homo sapiens

106

USP42

Affinity Capture-MS

Homo sapiens

107

MAP7

9053

Affinity Capture-MS

Homo sapiens

108

MAP4

4134

Affinity Capture-MS

Homo sapiens

109

UBE3A

7337

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

110

ARRDC4

Affinity Capture-MS

Homo sapiens

111

ZCCHC10

Affinity Capture-MS

Homo sapiens

112

CLPP

8192

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

113

SIRT7

Affinity Capture-MS

Homo sapiens

114

Tnks

Affinity Capture-MS

Mus musculus

115

UBE2L3

7332

Reconstituted Complex

Homo sapiens

116

CTNNB1

1499

Affinity Capture-MS

Homo sapiens

117

CKAP2

Affinity Capture-MS

Homo sapiens

118

PMCH

Affinity Capture-MS

Homo sapiens

119

SRGAP2

23380

Affinity Capture-MS

Homo sapiens

120

DUSP26

78986

Proximity Label-MS

Homo sapiens

121

CCP110

Affinity Capture-MS

Homo sapiens

122

BTF3

689

Affinity Capture-MS

Homo sapiens

123

EGFR

1956

Affinity Capture-MS

Homo sapiens

124

ATRIP

Affinity Capture-Western

Homo sapiens

125

FARP2

9855

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

126

NCKAP5

Affinity Capture-MS

Homo sapiens

127

Mus81

Affinity Capture-MS

Mus musculus

128

TANK

10010

Affinity Capture-MS

Homo sapiens

129

CDC42

998

Two-hybrid

Homo sapiens

130

TOP3A

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

131

ECI2

10455

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

132

CEP250

11190

Affinity Capture-MS

Homo sapiens

133

MAPK6

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

134

ARID3A

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

135

SPZ1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

136

HSDL2

84263

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

137

USP19

10869

Affinity Capture-MS

Homo sapiens

138

NDC80

10403

Proximity Label-MS

Homo sapiens

139

CDR2

Affinity Capture-MS

Homo sapiens

140

BICD1

636

Proximity Label-MS

Homo sapiens

141

KTN1

3895

Affinity Capture-MS

Homo sapiens

142

UBE2D2

7322

Reconstituted Complex

Homo sapiens

143

CCDC88A

55704

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

144

SIRT3

Affinity Capture-MS

Homo sapiens

145

MAP7D2

256714

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

146

BDKRB2

Two-hybrid

Homo sapiens

147

ALS2CR11

Affinity Capture-MS

Homo sapiens

148

MRPL18

29074

Affinity Capture-MS

Homo sapiens

149

CCDC8

Affinity Capture-MS

Homo sapiens

150

EIF3D

8664

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

151

UBE2D3

7323

Reconstituted Complex

Homo sapiens

152

UBE2D1

7321

Reconstituted Complex

Homo sapiens

153

ZRANB1

54764

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

154

ZNF669

Affinity Capture-MS

Homo sapiens

155

DNAJC28

Proximity Label-MS

Homo sapiens

156

EIF3F

8665

Affinity Capture-MS

Homo sapiens

157

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

158

CLSPN

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

159

SIRT6

Affinity Capture-MS

Homo sapiens

160

PDGFD

80310

Affinity Capture-MS

Homo sapiens

161

ARRDC5

Affinity Capture-MS

Homo sapiens

162

SEC23IP

11196

Affinity Capture-MS

Homo sapiens

163

TP53

7157

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

164

CDK8

1024

Affinity Capture-MS

Homo sapiens

165

PTRF

284119

Affinity Capture-MS

Homo sapiens

166

EIF3I

8668

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

167

PRIMPOL

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

168

HOXD13

Affinity Capture-MS

Homo sapiens

169

RPA1

6117

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

170

Cep135

Affinity Capture-MS

Mus musculus

171

KNOP1

400506

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

172

WRN

7486

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

173

NHLRC2

374354

Affinity Capture-MS

Homo sapiens

174

SAMD3

Affinity Capture-MS

Homo sapiens

175

FAM83H

286077

Affinity Capture-MS

Homo sapiens

176

MAGEA9

Affinity Capture-MS

Homo sapiens

177

SIRT1

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

178

SSBP1

6742

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

179

SMC3

9126

Affinity Capture-MS

Homo sapiens

180

TBK1

29110

Affinity Capture-MS

Homo sapiens

181

RPS24

6229

Affinity Capture-MS

Homo sapiens

182

GAPDH

2597

Cross-Linking-MS (XL-MS)

Homo sapiens

183

EFCAB1

Affinity Capture-MS

Homo sapiens

184

EIF3M

10480

Affinity Capture-MS

Homo sapiens

185

LRRK2

120892

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

186

STK33

Affinity Capture-MS

Homo sapiens

187

CEP135

Proximity Label-MS

Homo sapiens

188

APBA2

321

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

189

SSSCA1

10534

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

190

HERC3

8916

Affinity Capture-MS

Homo sapiens

191

STK11

6794

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

192

ERG

Reconstituted Complex

Homo sapiens

193

TXNIP

10628

Affinity Capture-MS

Homo sapiens

194

CCDC136

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

195

MRPL53

Affinity Capture-MS

Homo sapiens

196

ATOH1

Affinity Capture-MS

Homo sapiens

197

PSMC4

5704

Affinity Capture-MS

Homo sapiens

198

CEP170

9859

Affinity Capture-MS

Homo sapiens

199

RPA3

6119

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

200

FAM63A

55793

Affinity Capture-MS

Homo sapiens

201

USP20

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

202

EIF3L

51386

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

View the network

Pathways in which HERC2 is involved

Pathway	Evidence	Source
Adaptive Immune System	TAS	Reactome
Antigen processing: Ubiquitination & Proteasome degradation	TAS	Reactome
Cell Cycle	TAS	Reactome
Cell Cycle Checkpoints	TAS	Reactome
Class I MHC mediated antigen processing & presentation	TAS	Reactome
DNA Double Strand Break Response	TAS	Reactome
DNA Double-Strand Break Repair	TAS	Reactome
DNA Repair	TAS	Reactome
G2/M Checkpoints	TAS	Reactome
G2/M DNA damage checkpoint	TAS	Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	TAS	Reactome
Homology Directed Repair	TAS	Reactome
Immune System	TAS	Reactome
Metabolism of proteins	TAS	Reactome
Nonhomologous End-Joining (NHEJ)	TAS	Reactome
Post-translational protein modification	TAS	Reactome
Processing of DNA double-strand break ends	TAS	Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	TAS	Reactome
SUMO E3 ligases SUMOylate target proteins	TAS	Reactome
SUMOylation	TAS	Reactome
SUMOylation of DNA damage response and repair proteins	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here