Gene description for TAF6L
Gene name TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
Gene symbol TAF6L
Other names/aliases PAF65A
Species Homo sapiens
 Database cross references - TAF6L
ExoCarta ExoCarta_10629
Vesiclepedia VP_10629
Entrez Gene 10629
HGNC 17305
MIM 602946
UniProt Q9Y6J9  
 TAF6L identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TAF6L
Molecular Function
    DNA binding GO:0003677 TAS
    transcription coactivator activity GO:0003713 IBA
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II general transcription initiation factor activity GO:0016251 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    regulation of DNA repair GO:0006282 NAS
    chromatin remodeling GO:0006338 TAS
    regulation of DNA-templated transcription GO:0006355 ISS
    regulation of DNA-templated transcription GO:0006355 NAS
    regulation of transcription by RNA polymerase II GO:0006357 TAS
    regulation of RNA splicing GO:0043484 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    RNA polymerase II preinitiation complex assembly GO:0051123 IBA
    regulation of somatic stem cell population maintenance GO:1904672 ISS
Subcellular Localization
    histone deacetylase complex GO:0000118 TAS
    SAGA complex GO:0000124 IDA
    SAGA complex GO:0000124 NAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    transcription factor TFIID complex GO:0005669 IEA
    SLIK (SAGA-like) complex GO:0046695 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TAF6L in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TAF6L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TADA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TUSC2  
Affinity Capture-MS Homo sapiens
3 ARMC5 79798
Affinity Capture-MS Homo sapiens
4 TRRAP 8295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ATXN7L2  
Affinity Capture-MS Homo sapiens
6 TADA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZZZ3  
Affinity Capture-MS Homo sapiens
8 LOXL4 84171
Affinity Capture-MS Homo sapiens
9 STX11 8676
Two-hybrid Homo sapiens
10 SF3B5 83443
Affinity Capture-MS Homo sapiens
11 HDAC1 3065
Affinity Capture-MS Homo sapiens
12 MBIP  
Affinity Capture-MS Homo sapiens
13 TAF9 6880
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
14 TRMU  
Affinity Capture-MS Homo sapiens
15 CTLA4  
Affinity Capture-MS Homo sapiens
16 D2HGDH 728294
Affinity Capture-MS Homo sapiens
17 USP18  
Affinity Capture-MS Homo sapiens
18 KLF6  
Proximity Label-MS Homo sapiens
19 SLC31A1 1317
Affinity Capture-MS Homo sapiens
20 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 STIP1 10963
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 USP27X  
Affinity Capture-MS Homo sapiens
23 YEATS2  
Affinity Capture-MS Homo sapiens
24 PFDN5 5204
Two-hybrid Homo sapiens
25 TAF5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 EDC4 23644
Affinity Capture-MS Homo sapiens
28 KIAA1324 57535
Affinity Capture-MS Homo sapiens
29 FAM96A  
Affinity Capture-MS Homo sapiens
30 MANSC1 54682
Affinity Capture-MS Homo sapiens
31 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
32 TAF10 6881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PARK2  
Affinity Capture-MS Homo sapiens
34 SUPT7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PCDHB11  
Affinity Capture-MS Homo sapiens
36 TAF9B  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
37 CHRNB2  
Affinity Capture-MS Homo sapiens
38 RFX3 5991
Affinity Capture-MS Homo sapiens
39 PCDHGC4  
Affinity Capture-MS Homo sapiens
40 VCP 7415
Affinity Capture-MS Homo sapiens
41 TAF12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SUPT3H  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CCDC101  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 FBLN5 10516
Affinity Capture-MS Homo sapiens
45 ENY2 56943
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 MYH3 4621
Affinity Capture-MS Homo sapiens
47 XYLT2 64132
Affinity Capture-MS Homo sapiens
48 MYH4  
Affinity Capture-MS Homo sapiens
49 KLHL14 57565
Affinity Capture-MS Homo sapiens
50 NTRK1 4914
Affinity Capture-MS Homo sapiens
51 PCDHB7  
Affinity Capture-MS Homo sapiens
52 NUBP2 10101
Affinity Capture-MS Homo sapiens
53 MYOG  
Two-hybrid Homo sapiens
54 AOC3 8639
Affinity Capture-MS Homo sapiens
55 CSRP2BP  
Affinity Capture-MS Homo sapiens
56 EGFR 1956
Negative Genetic Homo sapiens
57 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 WDR37 22884
Affinity Capture-MS Homo sapiens
59 HIST3H3 8290
Protein-peptide Homo sapiens
60 KCNE3  
Affinity Capture-MS Homo sapiens
61 TADA2A  
Affinity Capture-MS Homo sapiens
62 MYC  
Proximity Label-MS Homo sapiens
63 MYH7 4625
Affinity Capture-MS Homo sapiens
64 SF3B3 23450
Affinity Capture-MS Homo sapiens
65 TADA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ATXN7L3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 PASK  
Affinity Capture-MS Homo sapiens
68 CCDC8  
Affinity Capture-MS Homo sapiens
69 USP51  
Affinity Capture-MS Homo sapiens
70 FASN 2194
Positive Genetic Homo sapiens
71 NAAA  
Affinity Capture-MS Homo sapiens
72 PARP1 142
Proximity Label-MS Homo sapiens
73 KAT2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SUPT20H 55578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 FBXL6  
Affinity Capture-MS Homo sapiens
76 OPALIN  
Affinity Capture-MS Homo sapiens
77 LDLRAD1  
Affinity Capture-MS Homo sapiens
78 KAT2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 ATXN7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CDH23 64072
Affinity Capture-MS Homo sapiens
81 MAMDC4  
Affinity Capture-MS Homo sapiens
82 CREBBP  
Reconstituted Complex Homo sapiens
83 MKI67  
Affinity Capture-MS Homo sapiens
84 PYGM 5837
Affinity Capture-MS Homo sapiens
85 BAG5 9529
Affinity Capture-MS Homo sapiens
86 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 KRAS 3845
Negative Genetic Homo sapiens
88 C9orf72  
Affinity Capture-MS Homo sapiens
89 AR 367
Proximity Label-MS Homo sapiens
90 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 PCDHB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TAF6L is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
HATs acetylate histones IEA Reactome





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