Gene description for XYLT2
Gene name xylosyltransferase II
Gene symbol XYLT2
Other names/aliases PXYLT2
XT-II
XT2
xylT-II
Species Homo sapiens
 Database cross references - XYLT2
ExoCarta ExoCarta_64132
Vesiclepedia VP_64132
Entrez Gene 64132
HGNC 15517
MIM 608125
UniProt Q9H1B5  
 XYLT2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for XYLT2
Molecular Function
    magnesium ion binding GO:0000287 IDA
    manganese ion binding GO:0030145 IDA
    protein xylosyltransferase activity GO:0030158 IBA
    protein xylosyltransferase activity GO:0030158 IDA
    protein xylosyltransferase activity GO:0030158 NAS
    protein xylosyltransferase activity GO:0030158 TAS
Biological Process
    glycosaminoglycan biosynthetic process GO:0006024 NAS
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IBA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IEA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IMP
    glycosaminoglycan metabolic process GO:0030203 TAS
    chondroitin sulfate biosynthetic process GO:0030206 IEA
    heparin biosynthetic process GO:0030210 IEA
    chondroitin sulfate proteoglycan biosynthetic process GO:0050650 IBA
    chondroitin sulfate proteoglycan biosynthetic process GO:0050650 IMP
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified XYLT2 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for XYLT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 IFNGR2  
Affinity Capture-MS Homo sapiens
3 CCL3  
Affinity Capture-MS Homo sapiens
4 GPIHBP1  
Affinity Capture-MS Homo sapiens
5 KCNMB3  
Affinity Capture-MS Homo sapiens
6 PTOV1  
Affinity Capture-MS Homo sapiens
7 FASN 2194
Positive Genetic Homo sapiens
8 TTYH1  
Affinity Capture-MS Homo sapiens
9 MTA2 9219
Affinity Capture-MS Homo sapiens
10 GPR17 2840
Affinity Capture-MS Homo sapiens
11 ATP5J 522
Affinity Capture-MS Homo sapiens
12 MFSD4  
Affinity Capture-MS Homo sapiens
13 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CAMK1D 57118
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 GPC1 2817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PDGFRA 5156
Affinity Capture-MS Homo sapiens
18 EDEM1  
Affinity Capture-MS Homo sapiens
19 PI15  
Affinity Capture-MS Homo sapiens
20 RFX1  
Affinity Capture-MS Homo sapiens
21 HDAC1 3065
Affinity Capture-MS Homo sapiens
22 KDSR 2531
Affinity Capture-MS Homo sapiens
23 TNFSF18 8995
Affinity Capture-MS Homo sapiens
24 LPAR1 1902
Affinity Capture-MS Homo sapiens
25 FOXJ1  
Affinity Capture-MS Homo sapiens
26 TBC1D32 221322
Affinity Capture-MS Homo sapiens
27 C12orf49  
Positive Genetic Homo sapiens
28 IDS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PBXIP1 57326
Affinity Capture-MS Homo sapiens
30 RFX3 5991
Affinity Capture-MS Homo sapiens
31 RTCB 51493
Affinity Capture-MS Homo sapiens
32 TAF6L 10629
Affinity Capture-MS Homo sapiens
33 SCGB2A2  
Affinity Capture-MS Homo sapiens
34 POMK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 GPC3 2719
Affinity Capture-MS Homo sapiens
36 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CDK20  
Affinity Capture-MS Homo sapiens
38 SUN3  
Affinity Capture-MS Homo sapiens
39 ATP5C1 509
Affinity Capture-MS Homo sapiens
40 DDX1 1653
Affinity Capture-MS Homo sapiens
41 ADGRE5 976
Affinity Capture-MS Homo sapiens
42 B4GALT3 8703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 B3GAT3 26229
Affinity Capture-MS Homo sapiens
44 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 DLL3  
Affinity Capture-MS Homo sapiens
46 XYLT1 64131
Negative Genetic Homo sapiens
47 UST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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