Gene description for XYLT1
Gene name xylosyltransferase I
Gene symbol XYLT1
Other names/aliases DBQD2
PXYLT1
XT-I
XT1
XTI
XYLTI
Species Homo sapiens
 Database cross references - XYLT1
ExoCarta ExoCarta_64131
Vesiclepedia VP_64131
Entrez Gene 64131
HGNC 15516
MIM 608124
UniProt Q86Y38  
 XYLT1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for XYLT1
Molecular Function
    protein xylosyltransferase activity GO:0030158 IBA
    protein xylosyltransferase activity GO:0030158 IDA
    protein xylosyltransferase activity GO:0030158 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    glycosaminoglycan biosynthetic process GO:0006024 TAS
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IBA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IEA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IMP
    proteoglycan biosynthetic process GO:0030166 IDA
    glycosaminoglycan metabolic process GO:0030203 TAS
    chondroitin sulfate biosynthetic process GO:0030206 IEA
    ossification involved in bone maturation GO:0043931 ISS
    embryonic skeletal system development GO:0048706 ISS
    chondroitin sulfate proteoglycan biosynthetic process GO:0050650 IBA
    chondroitin sulfate proteoglycan biosynthetic process GO:0050650 IMP
Subcellular Localization
    Golgi cis cisterna GO:0000137 ISS
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 TAS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified XYLT1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for XYLT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NELFCD 51497
Affinity Capture-MS Homo sapiens
2 MEF2A  
Affinity Capture-MS Homo sapiens
3 XYLT2 64132
Negative Genetic Homo sapiens
4 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 USP24 23358
Affinity Capture-MS Homo sapiens
6 NELFB 25920
Affinity Capture-MS Homo sapiens
7 NELFE 7936
Affinity Capture-MS Homo sapiens
8 FAM114A2  
Affinity Capture-MS Homo sapiens
9 NELFA  
Affinity Capture-MS Homo sapiens
10 ANKRD17 26057
Affinity Capture-MS Homo sapiens
11 ADH1C 126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ARFIP2 23647
Affinity Capture-MS Homo sapiens
13 CDK5RAP3 80279
Affinity Capture-MS Homo sapiens
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