Gene description for Aldh1l1
Gene name aldehyde dehydrogenase 1 family, member L1
Gene symbol Aldh1l1
Other names/aliases 1810048F20Rik
FDH
Fthfd
Neut2
Species Mus musculus
 Database cross references - Aldh1l1
ExoCarta ExoCarta_107747
Vesiclepedia VP_107747
Entrez Gene 107747
UniProt Q8R0Y6  
 Aldh1l1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aldh1l1
Molecular Function
    aldehyde dehydrogenase (NAD+) activity GO:0004029 IBA
    aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 ISO
    protein binding GO:0005515 IPI
    formyltetrahydrofolate dehydrogenase activity GO:0016155 IBA
    formyltetrahydrofolate dehydrogenase activity GO:0016155 IMP
    formyltetrahydrofolate dehydrogenase activity GO:0016155 ISO
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 IEA
    aldehyde dehydrogenase (NADP+) activity GO:0033721 ISO
    protein-containing complex binding GO:0044877 ISO
Biological Process
    one-carbon metabolic process GO:0006730 IEA
    NADPH regeneration GO:0006740 ISO
    NADPH regeneration GO:0006740 ISS
    biosynthetic process GO:0009058 IEA
    10-formyltetrahydrofolate catabolic process GO:0009258 IMP
    10-formyltetrahydrofolate catabolic process GO:0009258 ISO
    folic acid metabolic process GO:0046655 ISO
Subcellular Localization
    mitochondrion GO:0005739 HDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Aldh1l1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aldh1l1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Set 56086
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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