Gene description for Set
Gene name SET nuclear oncogene
Gene symbol Set
Other names/aliases 2610030F17Rik
5730420M11Rik
AA407739
I-2PP2A
StF-IT-1
TAF-I
Species Mus musculus
 Database cross references - Set
ExoCarta ExoCarta_56086
Vesiclepedia VP_56086
Entrez Gene 56086
UniProt Q9EQU5  
 Set identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Set
Molecular Function
    DNA binding GO:0003677 IEA
    chromatin binding GO:0003682 IBA
    chromatin binding GO:0003682 ISO
    histone binding GO:0042393 IBA
Biological Process
    nucleosome assembly GO:0006334 IEA
    negative regulation of neuron apoptotic process GO:0043524 ISO
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    lipid droplet GO:0005811 ISO
    cytosol GO:0005829 IEA
    protein-containing complex GO:0032991 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified Set in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Set
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nmt1  
Affinity Capture-MS Mus musculus
2 ZBTB11  
Affinity Capture-MS Homo sapiens
3 Tcp1 21454
Affinity Capture-MS Mus musculus
4 DNTTIP1 116092
Affinity Capture-MS Homo sapiens
5 Pold2  
Affinity Capture-MS Mus musculus
6 Cdk4  
Reconstituted Complex Mus musculus
7 Farsb 23874
Co-fractionation Mus musculus
8 APOE 348
Reconstituted Complex Homo sapiens
9 C14orf93  
Affinity Capture-MS Homo sapiens
10 Actb 11461
Affinity Capture-MS Mus musculus
11 Hspa5 14828
Affinity Capture-MS Mus musculus
12 Cct2 12461
Affinity Capture-MS Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
13 Tmem173  
Proximity Label-MS Mus musculus
14 KAT7  
Affinity Capture-MS Homo sapiens
15 Eef1a1 13627
Affinity Capture-MS Mus musculus
16 Cct8 12469
Affinity Capture-MS Mus musculus
17 PRKCDBP 112464
Affinity Capture-MS Homo sapiens
18 Swap70  
Co-fractionation Mus musculus
19 ZBTB21  
Affinity Capture-MS Homo sapiens
20 DDX24 57062
Affinity Capture-MS Homo sapiens
21 SOGA1 140710
Affinity Capture-MS Homo sapiens
22 ZMYND11 10771
Affinity Capture-MS Homo sapiens
23 ZNF197  
Affinity Capture-MS Homo sapiens
24 ATAD5  
Affinity Capture-MS Homo sapiens
25 Csnk2a2 13000
Reconstituted Complex Mus musculus
26 HCFC2  
Affinity Capture-MS Homo sapiens
27 POLRMT 5442
Affinity Capture-MS Homo sapiens
28 Csnk2a1 12995
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
29 MRPS7 51081
Affinity Capture-MS Homo sapiens
30 PKN3 29941
Affinity Capture-MS Homo sapiens
31 WDR5 11091
Affinity Capture-MS Homo sapiens
32 ZNF408  
Affinity Capture-MS Homo sapiens
33 SGOL2 151246
Affinity Capture-MS Homo sapiens
34 Eno1 13806
Affinity Capture-MS Mus musculus
35 BAZ1B 9031
Affinity Capture-MS Homo sapiens
36 ZKSCAN8  
Affinity Capture-MS Homo sapiens
37 UBN2  
Affinity Capture-MS Homo sapiens
38 Runx1 12394
Affinity Capture-MS Mus musculus
39 Supt6  
Affinity Capture-MS Mus musculus
40 Tfe3  
Affinity Capture-MS Mus musculus
41 Ftcd  
Affinity Capture-MS Mus musculus
42 Dnm2 13430
Affinity Capture-MS Mus musculus
43 JADE2 23338
Affinity Capture-MS Homo sapiens
44 ZNF91  
Affinity Capture-MS Homo sapiens
45 IKZF5 64376
Affinity Capture-MS Homo sapiens
46 Shmt2 108037
Affinity Capture-MS Mus musculus
47 SDPR 8436
Affinity Capture-MS Homo sapiens
48 Alb 11657
Affinity Capture-MS Mus musculus
49 ASH2L 9070
Affinity Capture-MS Homo sapiens
50 KMT2A  
Affinity Capture-MS Homo sapiens
51 Rab35 77407
Affinity Capture-MS Mus musculus
52 Cct5 12465
Affinity Capture-MS Mus musculus
53 Kdm3a  
Affinity Capture-MS Mus musculus
54 Ntmt1  
Co-fractionation Mus musculus
55 SMARCA5 8467
Affinity Capture-MS Homo sapiens
56 ZBTB24  
Affinity Capture-MS Homo sapiens
57 GTF3C1  
Affinity Capture-MS Homo sapiens
58 RFC2 5982
Affinity Capture-MS Homo sapiens
59 Ptma  
Co-fractionation Mus musculus
60 DCAF13 25879
Affinity Capture-MS Homo sapiens
61 Pygm  
Affinity Capture-MS Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
62 Mib2  
Affinity Capture-MS Mus musculus
63 RBBP4 5928
Affinity Capture-MS Homo sapiens
64 ELMSAN1  
Affinity Capture-MS Homo sapiens
65 Csnk1e  
Affinity Capture-MS Mus musculus
66 Ranbp3  
Co-fractionation Mus musculus
67 Anp32a 11737
Reconstituted Complex Mus musculus
68 BAG1 573
Affinity Capture-MS Homo sapiens
69 Hspa1l 15482
Affinity Capture-MS Mus musculus
70 FAM111B 374393
Affinity Capture-MS Homo sapiens
71 Atp5b 11947
Affinity Capture-MS Mus musculus
72 ZFP91 80829
Affinity Capture-MS Homo sapiens
73 Ppp2r5b  
Affinity Capture-MS Mus musculus
74 MATR3 9782
Affinity Capture-MS Homo sapiens
75 Eif2s1 13665
Affinity Capture-MS Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
76 ASH1L 55870
Affinity Capture-MS Homo sapiens
77 ZC3H3  
Affinity Capture-MS Homo sapiens
78 ZNF574  
Affinity Capture-MS Homo sapiens
79 Aldh1l1 107747
Affinity Capture-MS Mus musculus
80 MTCL1 23255
Affinity Capture-MS Homo sapiens
81 RRP36 88745
Affinity Capture-MS Homo sapiens
82 PRDM10  
Affinity Capture-MS Homo sapiens
83 ZNF236  
Affinity Capture-MS Homo sapiens
84 PTRF 284119
Affinity Capture-MS Homo sapiens
85 Apoe 11816
Affinity Capture-MS Mus musculus
Protein-peptide Mus musculus
86 ZNF445  
Affinity Capture-MS Homo sapiens
87 MEN1 4221
Affinity Capture-MS Homo sapiens
88 ZKSCAN1  
Affinity Capture-MS Homo sapiens
89 Ccnd2 12444
Reconstituted Complex Mus musculus
90 MORF4L2  
Affinity Capture-MS Homo sapiens
91 Dhrs4  
Affinity Capture-MS Mus musculus
92 TSPYL1 7259
Affinity Capture-MS Homo sapiens
93 Sall4  
Affinity Capture-MS Mus musculus
94 SUGP2  
Affinity Capture-MS Homo sapiens
95 Mta1  
Affinity Capture-MS Mus musculus
96 ZNF646  
Affinity Capture-MS Homo sapiens
97 Atg5  
Affinity Capture-RNA Mus musculus
98 TRIM28 10155
Affinity Capture-MS Homo sapiens
99 Fbp1  
Affinity Capture-MS Mus musculus
100 Hnrnpa2b1 53379
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-MS Mus musculus
101 ZNF845  
Affinity Capture-MS Homo sapiens
102 Selenbp2  
Affinity Capture-MS Mus musculus
103 UBN1  
Affinity Capture-MS Homo sapiens
104 PWWP2A  
Affinity Capture-MS Homo sapiens
105 Supt5  
Co-fractionation Mus musculus
106 REPIN1  
Affinity Capture-MS Homo sapiens
107 PRKRIR  
Affinity Capture-MS Homo sapiens
108 ZNF770 54989
Affinity Capture-MS Homo sapiens
109 CDKN2A 1029
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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