Gene description for PKN3
Gene name protein kinase N3
Gene symbol PKN3
Other names/aliases UTDP4-1
Species Homo sapiens
 Database cross references - PKN3
ExoCarta ExoCarta_29941
Vesiclepedia VP_29941
Entrez Gene 29941
HGNC 17999
MIM 610714
UniProt Q6P5Z2  
 PKN3 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for PKN3
Molecular Function
    protein kinase activity GO:0004672 TAS
    protein serine/threonine kinase activity GO:0004674 IBA
    calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0004698 IEA
    diacylglycerol-dependent, calcium-independent serine/threonine kinase activity GO:0004699 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    small GTPase binding GO:0031267 IEA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    protein phosphorylation GO:0006468 TAS
    signal transduction GO:0007165 TAS
    epithelial cell migration GO:0010631 IDA
    intracellular signal transduction GO:0035556 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    Golgi apparatus GO:0005794 TAS
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified PKN3 in sEVs
1
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for PKN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUF2  
Affinity Capture-MS Homo sapiens
2 CX3CL1  
Affinity Capture-MS Homo sapiens
3 Tpm1 22003
Affinity Capture-MS Mus musculus
4 CALML3 810
Affinity Capture-MS Homo sapiens
5 HCST  
Affinity Capture-MS Homo sapiens
6 TMF1 7110
Affinity Capture-MS Homo sapiens
7 CCDC132 55610
Affinity Capture-MS Homo sapiens
8 S100A6 6277
Affinity Capture-MS Homo sapiens
9 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
10 GIT2 9815
Affinity Capture-MS Homo sapiens
11 P4HA2 8974
Affinity Capture-MS Homo sapiens
12 NUP62 23636
Affinity Capture-MS Homo sapiens
13 Chmp4b 75608
Affinity Capture-MS Mus musculus
14 NUDCD3 23386
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
15 STRN3 29966
Affinity Capture-MS Homo sapiens
16 APBA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 GRIPAP1 56850
Affinity Capture-MS Homo sapiens
18 PPIA 5478
Affinity Capture-MS Homo sapiens
19 TUFT1  
Affinity Capture-MS Homo sapiens
20 ARNTL  
Affinity Capture-MS Homo sapiens
21 AMHR2  
Affinity Capture-MS Homo sapiens
22 CCDC122  
Affinity Capture-MS Homo sapiens
23 S100A4 6275
Affinity Capture-MS Homo sapiens
24 STRN 6801
Affinity Capture-MS Homo sapiens
25 SKA1  
Affinity Capture-MS Homo sapiens
26 SPECC1L 23384
Affinity Capture-MS Homo sapiens
27 CFAP97  
Affinity Capture-MS Homo sapiens
28 PSMD9 5715
Affinity Capture-MS Homo sapiens
29 Ankrd26  
Affinity Capture-MS Mus musculus
30 OIP5  
Affinity Capture-MS Homo sapiens
31 MTUS2 23281
Two-hybrid Homo sapiens
32 Snrnp70 20637
Affinity Capture-MS Mus musculus
33 Set 56086
Affinity Capture-MS Mus musculus
34 HAUS6  
Affinity Capture-MS Homo sapiens
35 RHOB 388
Proximity Label-MS Homo sapiens
36 AVPR1B  
Affinity Capture-MS Homo sapiens
37 VPS53 55275
Affinity Capture-MS Homo sapiens
38 IL17RA 23765
Affinity Capture-MS Homo sapiens
39 SNX27 81609
Affinity Capture-MS Homo sapiens
40 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 IFT20 90410
Affinity Capture-MS Homo sapiens
42 VSIG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RABGEF1 27342
Affinity Capture-MS Homo sapiens
44 CLOCK  
Affinity Capture-MS Homo sapiens
45 Mgp 17313
Affinity Capture-MS Mus musculus
46 RHOA 387
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 HMG20A  
Affinity Capture-MS Homo sapiens
49 ACVR2B  
Affinity Capture-MS Homo sapiens
50 MOB4 25843
Affinity Capture-MS Homo sapiens
51 VPS51 738
Affinity Capture-MS Homo sapiens
52 RABEP1 9135
Affinity Capture-MS Homo sapiens
53 Taf15  
Affinity Capture-MS Mus musculus
54 PRPS2 5634
Affinity Capture-MS Homo sapiens
55 Arrb2  
Affinity Capture-MS Mus musculus
56 ITGB3BP  
Affinity Capture-MS Homo sapiens
57 TUBA1C 84790
Affinity Capture-MS Homo sapiens
58 CDH5  
Affinity Capture-MS Homo sapiens
59 PNMA2  
Affinity Capture-MS Homo sapiens
60 PPP2CA 5515
Affinity Capture-MS Homo sapiens
61 KRT31 3881
Affinity Capture-MS Homo sapiens
62 Hnrnpf 98758
Affinity Capture-MS Mus musculus
63 GIT1 28964
Affinity Capture-MS Homo sapiens
64 Pcna 18538
Affinity Capture-MS Mus musculus
65 DEF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 EFNB3 1949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 YEATS4  
Affinity Capture-MS Homo sapiens
68 NCKAP5L  
Affinity Capture-MS Homo sapiens
69 HNRNPD 3184
Affinity Capture-MS Homo sapiens
70 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 TSSC1 7260
Affinity Capture-MS Homo sapiens
72 ARHGAP10 79658
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
73 BTNL9  
Affinity Capture-MS Homo sapiens
74 KIF20A 10112
Affinity Capture-MS Homo sapiens
75 LRRC25  
Affinity Capture-MS Homo sapiens
76 PTH2R  
Affinity Capture-MS Homo sapiens
77 PHLDB3  
Affinity Capture-MS Homo sapiens
78 RPRD1A  
Affinity Capture-MS Homo sapiens
79 TFPT  
Affinity Capture-MS Homo sapiens
80 HSP90AA5P 730211
Affinity Capture-MS Homo sapiens
81 KCNE3  
Affinity Capture-MS Homo sapiens
82 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
83 PCDH10 57575
Affinity Capture-MS Homo sapiens
84 HECW2  
Affinity Capture-MS Homo sapiens
85 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 PHF21A  
Affinity Capture-MS Homo sapiens
87 RABGAP1L 9910
Affinity Capture-MS Homo sapiens
88 Kctd5  
Affinity Capture-MS Mus musculus
89 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PPP2CB 5516
Affinity Capture-MS Homo sapiens
91 GOLGA2 2801
Two-hybrid Homo sapiens
92 DZIP3  
Affinity Capture-MS Homo sapiens
93 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
94 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
95 CEP170P1  
Affinity Capture-MS Homo sapiens
96 TGFBR2 7048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 MAX  
Affinity Capture-MS Homo sapiens
98 TUBG1 7283
Affinity Capture-MS Homo sapiens
99 TSPYL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 HDAC6 10013
Affinity Capture-MS Homo sapiens
101 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 CCHCR1  
Affinity Capture-MS Homo sapiens
103 LCK 3932
Proximity Label-MS Homo sapiens
104 VPS52 6293
Two-hybrid Homo sapiens
105 EFNB1 1947
Affinity Capture-MS Homo sapiens
106 THAP11 57215
Affinity Capture-MS Homo sapiens
107 PNMA1 9240
Two-hybrid Homo sapiens
108 C15orf59  
Affinity Capture-MS Homo sapiens
109 FEM1B 10116
Affinity Capture-MS Homo sapiens
110 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 CCDC93 54520
Affinity Capture-MS Homo sapiens
112 LURAP1  
Affinity Capture-MS Homo sapiens
113 DHX40  
Co-fractionation Homo sapiens
114 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 KRT38 8687
Affinity Capture-MS Homo sapiens
116 GOLGA5 9950
Affinity Capture-MS Homo sapiens
117 SSSCA1 10534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 ZUFSP 221302
Affinity Capture-MS Homo sapiens
119 TXNIP 10628
Affinity Capture-MS Homo sapiens
120 HNRNPU 3192
Affinity Capture-MS Homo sapiens
121 TRIM29 23650
Affinity Capture-MS Homo sapiens
122 PTRF 284119
Affinity Capture-MS Homo sapiens
123 RCOR1  
Affinity Capture-MS Homo sapiens
124 S100A2 6273
Affinity Capture-MS Homo sapiens
125 CPSF3 51692
Affinity Capture-MS Homo sapiens
126 OPALIN  
Affinity Capture-MS Homo sapiens
127 HSPA2 3306
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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