Gene description for Mgp
Gene name matrix Gla protein
Gene symbol Mgp
Other names/aliases Mglap
Species Mus musculus
 Database cross references - Mgp
ExoCarta ExoCarta_17313
Vesiclepedia VP_17313
Entrez Gene 17313
UniProt P19788  
 Mgp identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mgp
Molecular Function
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    calcium-dependent protein binding GO:0048306 ISO
Biological Process
    ossification GO:0001503 IEA
    cell differentiation GO:0030154 IEA
    lung development GO:0030324 ISO
    regulation of bone mineralization GO:0030500 IEA
    branching morphogenesis of an epithelial tube GO:0048754 ISO
    cartilage development GO:0051216 IEA
    protein-containing complex assembly GO:0065003 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 IBA
    protein-containing complex GO:0032991 ISO
    collagen-containing extracellular matrix GO:0062023 IEA
    collagen-containing extracellular matrix GO:0062023 ISO
 Experiment description of studies that identified Mgp in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mgp
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBR5 51366
Affinity Capture-MS Homo sapiens
2 HEATR1 55127
Affinity Capture-MS Homo sapiens
3 CALU 813
Affinity Capture-MS Homo sapiens
4 UBR4 23352
Affinity Capture-MS Homo sapiens
5 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
6 TTI1 9675
Affinity Capture-MS Homo sapiens
7 RNF219  
Affinity Capture-MS Homo sapiens
8 PKN3 29941
Affinity Capture-MS Homo sapiens
9 GANAB 23193
Affinity Capture-MS Homo sapiens
10 HNRNPM 4670
Affinity Capture-MS Homo sapiens
11 SQSTM1 8878
Affinity Capture-MS Homo sapiens
12 HADHB 3032
Affinity Capture-MS Homo sapiens
13 UBR1 197131
Affinity Capture-MS Homo sapiens
14 GGCX 2677
Affinity Capture-MS Homo sapiens
15 RASAL2 9462
Affinity Capture-MS Homo sapiens
16 HSP90B1 7184
Affinity Capture-MS Homo sapiens
17 RCN1 5954
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Mgp is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here