Gene description for GGCX
Gene name gamma-glutamyl carboxylase
Gene symbol GGCX
Other names/aliases VKCFD1
Species Homo sapiens
 Database cross references - GGCX
ExoCarta ExoCarta_2677
Vesiclepedia VP_2677
Entrez Gene 2677
HGNC 4247
MIM 137167
UniProt P38435  
 GGCX identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GGCX
Molecular Function
    gamma-glutamyl carboxylase activity GO:0008488 IBA
    gamma-glutamyl carboxylase activity GO:0008488 IDA
    gamma-glutamyl carboxylase activity GO:0008488 TAS
    vitamin binding GO:0019842 IBA
Biological Process
    blood coagulation GO:0007596 TAS
    protein modification process GO:0036211 TAS
    vitamin K metabolic process GO:0042373 IBA
    vitamin K metabolic process GO:0042373 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 TAS
 Experiment description of studies that identified GGCX in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GGCX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK2 7379
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 PRRG4  
Affinity Capture-MS Homo sapiens
4 Anapc2  
Affinity Capture-MS Mus musculus
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 ADORA2B  
Affinity Capture-MS Homo sapiens
7 Tubg1 103733
Affinity Capture-MS Mus musculus
8 APLNR  
Affinity Capture-MS Homo sapiens
9 CXCR4 7852
Affinity Capture-MS Homo sapiens
10 CANX 821
Affinity Capture-MS Homo sapiens
11 NPDC1  
Affinity Capture-MS Homo sapiens
12 GP9 2815
Affinity Capture-MS Homo sapiens
13 Mad2l1bp  
Affinity Capture-MS Mus musculus
14 AP1S2 8905
Affinity Capture-MS Homo sapiens
15 SGCA  
Affinity Capture-MS Homo sapiens
16 LRRC25  
Affinity Capture-MS Homo sapiens
17 FGD1  
Affinity Capture-MS Homo sapiens
18 Mgp 17313
Affinity Capture-MS Mus musculus
19 CLEC2D  
Affinity Capture-MS Homo sapiens
20 CD70 970
Affinity Capture-MS Homo sapiens
21 PRRG1 5638
Affinity Capture-MS Homo sapiens
22 CUL3 8452
Affinity Capture-MS Homo sapiens
23 TRIM33 51592
Affinity Capture-MS Homo sapiens
24 B4GAT1 11041
Affinity Capture-MS Homo sapiens
25 HCST  
Affinity Capture-MS Homo sapiens
26 TERF2IP 54386
Affinity Capture-MS Homo sapiens
27 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TMEM72  
Affinity Capture-MS Homo sapiens
29 AQP3  
Affinity Capture-MS Homo sapiens
30 ENTPD7  
Affinity Capture-MS Homo sapiens
31 FFAR1  
Affinity Capture-MS Homo sapiens
32 SLC22A9  
Affinity Capture-MS Homo sapiens
33 Cdc16  
Affinity Capture-MS Mus musculus
34 SEC62 7095
Proximity Label-MS Homo sapiens
35 ATP2A1 487
Proximity Label-MS Homo sapiens
36 FBXO2 26232
Affinity Capture-MS Homo sapiens
37 GPR45  
Affinity Capture-MS Homo sapiens
38 CMTM5  
Affinity Capture-MS Homo sapiens
39 HLA-B 3106
Affinity Capture-MS Homo sapiens
40 GPR182  
Affinity Capture-MS Homo sapiens
41 FAM46A  
Affinity Capture-MS Homo sapiens
42 TMEM9 252839
Affinity Capture-MS Homo sapiens
43 RAB7A 7879
Proximity Label-MS Homo sapiens
44 C4BPB 725
Affinity Capture-MS Homo sapiens
45 C9orf72  
Affinity Capture-MS Homo sapiens
46 GPBAR1  
Affinity Capture-MS Homo sapiens
47 DCP2  
Affinity Capture-MS Homo sapiens
48 PAEP  
Affinity Capture-MS Homo sapiens
49 Ncstn 59287
Affinity Capture-MS Mus musculus
50 Smn1 20595
Affinity Capture-MS Mus musculus
51 TMCO3 55002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 DERL1 79139
Proximity Label-MS Homo sapiens
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