Gene description for Ccnd2
Gene name cyclin D2
Gene symbol Ccnd2
Other names/aliases 2600016F06Rik
AI256817
BF642806
C86853
Vin-1
Vin1
cD2
Species Mus musculus
 Database cross references - Ccnd2
ExoCarta ExoCarta_12444
Vesiclepedia VP_12444
Entrez Gene 12444
UniProt P30280  
 Ccnd2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ccnd2
Molecular Function
    protein binding GO:0005515 IPI
    cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IBA
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    cyclin-dependent protein serine/threonine kinase activator activity GO:0061575 IEA
    cyclin-dependent protein serine/threonine kinase activator activity GO:0061575 ISO
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IBA
    G1/S transition of mitotic cell cycle GO:0000082 ISO
    G1/S transition of mitotic cell cycle GO:0000082 NAS
    positive regulation of protein phosphorylation GO:0001934 ISO
    long-term memory GO:0007616 IMP
    positive regulation of cell population proliferation GO:0008284 IEA
    positive regulation of cell population proliferation GO:0008284 ISO
    adult locomotory behavior GO:0008344 IMP
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 ISO
    positive regulation of epithelial cell proliferation GO:0050679 ISO
    cell division GO:0051301 IEA
    regulation of cell cycle GO:0051726 IMP
    positive regulation of cardiac muscle cell proliferation GO:0060045 ISO
    cellular response to X-ray GO:0071481 IMP
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IBA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 ISO
    negative regulation of cardiac muscle cell differentiation GO:2000726 ISO
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 IBA
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 ISO
    chromatin GO:0000785 IEA
    chromatin GO:0000785 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IBA
    microtubule organizing center GO:0005815 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    nuclear membrane GO:0031965 IEA
    nuclear membrane GO:0031965 ISO
    cyclin D2-CDK4 complex GO:0097129 IDA
    cyclin D2-CDK4 complex GO:0097129 ISO
 Experiment description of studies that identified Ccnd2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ccnd2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cdkn1b  
Affinity Capture-Western Mus musculus
2 Cdk4  
Affinity Capture-Western Mus musculus
3 Set 56086
Reconstituted Complex Mus musculus
4 Cdk2  
Affinity Capture-Western Mus musculus
5 Cdk6 12571
Affinity Capture-Western Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here