Gene description for Egln1
Gene name	egl-9 family hypoxia-inducible factor 1
Gene symbol	Egln1
Other names/aliases	AI503754 C1orf12 HIF-PH2 HPH-2 Hif-p4h-2 ORF13 Phd2 SM-20
Species	Mus musculus
Database cross references - Egln1
ExoCarta	ExoCarta_112405
Vesiclepedia	VP_112405
Entrez Gene	112405
UniProt	Q91YE3
Egln1 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Egln1

Molecular Function     ferrous iron binding GO:0008198 IBA     ferrous iron binding GO:0008198 ISO     ferrous iron binding GO:0008198 ISS     2-oxoglutarate-dependent dioxygenase activity GO:0016706 ISO     enzyme binding GO:0019899 ISO     L-ascorbic acid binding GO:0031418 IEA     peptidyl-proline dioxygenase activity GO:0031543 ISO     peptidyl-proline 4-dioxygenase activity GO:0031545 IBA     hypoxia-inducible factor-proline dioxygenase activity GO:0160082 IEA     hypoxia-inducible factor-proline dioxygenase activity GO:0160082 ISO Biological Process     response to hypoxia GO:0001666 IEA     response to hypoxia GO:0001666 ISO     intracellular iron ion homeostasis GO:0006879 IMP     intracellular oxygen homeostasis GO:0032364 IEA     intracellular oxygen homeostasis GO:0032364 ISO     positive regulation of apoptotic process GO:0043065 ISO     negative regulation of DNA-binding transcription factor activity GO:0043433 ISO     regulation of neuron apoptotic process GO:0043523 IBA     positive regulation of neuron apoptotic process GO:0043525 ISO     regulation of angiogenesis GO:0045765 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     cardiac muscle tissue morphogenesis GO:0055008 IMP     heart trabecula formation GO:0060347 IMP     ventricular septum morphogenesis GO:0060412 IMP     labyrinthine layer development GO:0060711 IMP     cellular response to hypoxia GO:0071456 IBA     response to nitric oxide GO:0071731 ISO     response to nitric oxide GO:0071731 ISS     regulation of modification of postsynaptic structure GO:0099159 IDA     regulation of modification of postsynaptic structure GO:0099159 IEP     regulation of modification of postsynaptic structure GO:0099159 IMP     regulation protein catabolic process at postsynapse GO:0140252 IDA     regulation protein catabolic process at postsynapse GO:0140252 IEP     regulation protein catabolic process at postsynapse GO:0140252 IMP     negative regulation of CAMKK-AMPK signaling cascade GO:1905290 ISO Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IEA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     postsynaptic density GO:0014069 IDA     postsynaptic density GO:0014069 IEP     intracellular membrane-bounded organelle GO:0043231 ISO     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IEP     glutamatergic synapse GO:0098978 IMP