Gene description for Acta1
Gene name actin, alpha 1, skeletal muscle
Gene symbol Acta1
Other names/aliases AA959943
Acta-2
Acts
Actsk-1
Species Mus musculus
 Database cross references - Acta1
ExoCarta ExoCarta_11459
Vesiclepedia VP_11459
Entrez Gene 11459
UniProt P68134  
 Acta1 identified in sEVs derived from the following tissue/cell type
Brain cancer cells 19109410    
Pancreatic cells 19351151    
 Gene ontology annotations for Acta1
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    hydrolase activity GO:0016787 IEA
Biological Process
    response to mechanical stimulus GO:0009612 IEA
    positive regulation of gene expression GO:0010628 ISS
    skeletal muscle thin filament assembly GO:0030240 IBA
    skeletal muscle thin filament assembly GO:0030240 ISO
    skeletal muscle thin filament assembly GO:0030240 ISS
    cellular response to potassium ion GO:0035865 IEA
    skeletal muscle fiber adaptation GO:0043503 IEA
    response to steroid hormone GO:0048545 IEA
    skeletal muscle fiber development GO:0048741 IDA
    mesenchyme migration GO:0090131 ISS
Subcellular Localization
    stress fiber GO:0001725 IBA
    stress fiber GO:0001725 ISO
    stress fiber GO:0001725 ISS
    cytoplasm GO:0005737 ISS
    striated muscle thin filament GO:0005865 IBA
    striated muscle thin filament GO:0005865 ISO
    striated muscle thin filament GO:0005865 TAS
    actin filament GO:0005884 IBA
    actin filament GO:0005884 ISO
    actin filament GO:0005884 ISS
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 ISO
    sarcomere GO:0030017 ISO
    lamellipodium GO:0030027 ISS
    filopodium GO:0030175 ISS
    protein-containing complex GO:0032991 ISO
    cell body GO:0044297 ISS
 Experiment description of studies that identified Acta1 in sEVs
1
Experiment ID 26
MISEV standards
EM
Biophysical techniques
Alix|GAPDH|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19109410    
Organism Mus musculus
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors "Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD"
Journal name FASEB
Publication year 2008
Sample Brain cancer cells
Sample name SMA560vIII
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
2
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Acta1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Acta1 11459
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
2 Zbtb7b  
Affinity Capture-MS Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Ipp  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
5 Hip1r  
Reconstituted Complex Mus musculus
6 Snca  
Affinity Capture-Western Mus musculus
7 Atxn1  
Proximity Label-MS Mus musculus
8 Kctd13  
Affinity Capture-MS Mus musculus
9 LSM7  
Two-hybrid Homo sapiens
10 SF1 7536
Two-hybrid Homo sapiens
11 Trim32  
Reconstituted Complex Mus musculus
Biochemical Activity Mus musculus
12 Pygm  
Co-fractionation Mus musculus
13 Klhl40  
Affinity Capture-MS Mus musculus
14 Park2  
Affinity Capture-Western Mus musculus
15 Trim63  
Affinity Capture-MS Mus musculus
Biochemical Activity Mus musculus
16 YTHDF1 54915
Two-hybrid Homo sapiens
17 Ywhaz 22631
Affinity Capture-MS Mus musculus
18 Htatsf1  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Acta1 is involved
PathwayEvidenceSource
Muscle contraction IEA Reactome
Striated Muscle Contraction IEA Reactome





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