Gene description for Arpc1b
Gene name actin related protein 2/3 complex, subunit 1B
Gene symbol Arpc1b
Other names/aliases 41kDa
AA408064
AA408534
AA571392
AF007010
AW208418
L72
SOP2Hs
p41-ARC
Species Mus musculus
 Database cross references - Arpc1b
ExoCarta ExoCarta_11867
Vesiclepedia VP_11867
Entrez Gene 11867
UniProt Q9WV32  
 Arpc1b identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Arpc1b
Molecular Function
    actin binding GO:0003779 IEA
    structural constituent of cytoskeleton GO:0005200 ISO
    protein-containing complex binding GO:0044877 ISO
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 ISO
Biological Process
    Arp2/3 complex-mediated actin nucleation GO:0034314 IBA
    Arp2/3 complex-mediated actin nucleation GO:0034314 IEA
    Arp2/3 complex-mediated actin nucleation GO:0034314 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    Arp2/3 protein complex GO:0005885 IBA
    Arp2/3 protein complex GO:0005885 ISO
    Arp2/3 protein complex GO:0005885 TAS
    tubulobulbar complex GO:0036284 ISO
 Experiment description of studies that identified Arpc1b in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Arpc1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Calu  
Co-fractionation Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
3 Foxp3  
Affinity Capture-MS Mus musculus
4 Rangap1  
Co-fractionation Mus musculus
5 Lmna 16905
Affinity Capture-MS Mus musculus
6 Tpd52  
Co-fractionation Mus musculus
7 Anp32b 67628
Co-fractionation Mus musculus
8 Kctd13  
Affinity Capture-MS Mus musculus
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