Gene description for FAT3
Gene name FAT atypical cadherin 3
Gene symbol FAT3
Other names/aliases CDHF15
CDHR10
Species Homo sapiens
 Database cross references - FAT3
ExoCarta ExoCarta_120114
Vesiclepedia VP_120114
Entrez Gene 120114
HGNC 23112
MIM 612483
UniProt Q8TDW7  
 FAT3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for FAT3
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    retina layer formation GO:0010842 IEA
    dendrite development GO:0016358 IEA
    cell morphogenesis involved in neuron differentiation GO:0048667 IEA
    cell-cell adhesion GO:0098609 IBA
    interneuron migration GO:1904936 IEA
    negative regulation of dendrite development GO:2000171 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    dendrite GO:0030425 IEA
 Experiment description of studies that identified FAT3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FAT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBPJL  
Affinity Capture-MS Homo sapiens
2 C14orf79  
Affinity Capture-MS Homo sapiens
3 C2CD4B  
Affinity Capture-MS Homo sapiens
4 DCDC2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ZBBX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C2CD4A  
Affinity Capture-MS Homo sapiens
7 C1orf115  
Affinity Capture-MS Homo sapiens
8 SIRT6  
Affinity Capture-MS Homo sapiens
9 PSG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PDGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SPSB4  
Affinity Capture-MS Homo sapiens
12 C2orf48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DUXAP10  
Affinity Capture-MS Homo sapiens
14 FBXO10  
Affinity Capture-MS Homo sapiens
15 C15orf53  
Affinity Capture-MS Homo sapiens
16 LINC01588  
Affinity Capture-MS Homo sapiens
17 TRIM66  
Affinity Capture-MS Homo sapiens
18 DCDC1  
Affinity Capture-MS Homo sapiens
19 CC2D1B 200014
Affinity Capture-MS Homo sapiens
20 SSX6  
Affinity Capture-MS Homo sapiens
21 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FAM218A  
Affinity Capture-MS Homo sapiens
23 CX3CL1  
Affinity Capture-MS Homo sapiens
24 COMMD2 51122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 LGALS1 3956
Affinity Capture-MS Homo sapiens
26 SOCS1  
Affinity Capture-MS Homo sapiens
27 RPL23 9349
Affinity Capture-MS Homo sapiens
28 C4orf26  
Affinity Capture-MS Homo sapiens
29 LOC254896  
Affinity Capture-MS Homo sapiens
30 ADAMTS13 11093
Affinity Capture-MS Homo sapiens
31 IL17RE  
Affinity Capture-MS Homo sapiens
32 B4GALT2  
Affinity Capture-MS Homo sapiens
33 SOCS7  
Affinity Capture-MS Homo sapiens
34 DTX4 23220
Affinity Capture-MS Homo sapiens
35 HPRT1 3251
Co-fractionation Homo sapiens
36 DDX39A 10212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 DCANP1  
Affinity Capture-MS Homo sapiens
38 PTP4A3  
Affinity Capture-MS Homo sapiens
39 UCN3  
Affinity Capture-MS Homo sapiens
40 C17orf102  
Affinity Capture-MS Homo sapiens
41 TCF15  
Affinity Capture-MS Homo sapiens
42 TRMU  
Affinity Capture-MS Homo sapiens
43 NAT8L 339983
Affinity Capture-MS Homo sapiens
44 XCL1  
Affinity Capture-MS Homo sapiens
45 CD160  
Affinity Capture-MS Homo sapiens
46 XAGE1B  
Affinity Capture-MS Homo sapiens
47 AKT2 208
Affinity Capture-MS Homo sapiens
48 RPL28 6158
Affinity Capture-MS Homo sapiens
49 CBX6  
Affinity Capture-MS Homo sapiens
50 PER3  
Affinity Capture-MS Homo sapiens
51 CARD16  
Affinity Capture-MS Homo sapiens
52 NUP210P1  
Affinity Capture-MS Homo sapiens
53 DTWD2  
Affinity Capture-MS Homo sapiens
54 SPATA4  
Affinity Capture-MS Homo sapiens
55 PPIAL4G  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 DUX3  
Affinity Capture-MS Homo sapiens
57 C16orf46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 RPS14P3  
Affinity Capture-MS Homo sapiens
59 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 COL20A1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAT3 is involved
No pathways found





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