Gene description for LYPLAL1
Gene name lysophospholipase-like 1
Gene symbol LYPLAL1
Other names/aliases Q96AV0
Species Homo sapiens
 Database cross references - LYPLAL1
ExoCarta ExoCarta_127018
Vesiclepedia VP_127018
Entrez Gene 127018
HGNC 20440
UniProt Q5VWZ2  
 LYPLAL1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for LYPLAL1
Molecular Function
    lysophospholipase activity GO:0004622 NAS
    protein binding GO:0005515 IPI
    palmitoyl-(protein) hydrolase activity GO:0008474 IBA
    palmitoyl-(protein) hydrolase activity GO:0008474 IDA
    lipase activity GO:0016298 IDA
    hydrolase activity, acting on ester bonds GO:0016788 IDA
    carboxylic ester hydrolase activity GO:0052689 IBA
Biological Process
    negative regulation of Golgi to plasma membrane protein transport GO:0042997 IBA
    macromolecule depalmitoylation GO:0098734 IEA
    negative regulation of cGAS/STING signaling pathway GO:0160049 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    cytosol GO:0005829 IDA
 Experiment description of studies that identified LYPLAL1 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LYPLAL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FABP3 2170
Co-fractionation Homo sapiens
2 SUMF2 25870
Co-fractionation Homo sapiens
3 RAMP3  
Affinity Capture-MS Homo sapiens
4 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
5 PRTN3 5657
Affinity Capture-MS Homo sapiens
6 GOT2 2806
Co-fractionation Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 SH3BGRL 6451
Co-fractionation Homo sapiens
9 TSFM 10102
Proximity Label-MS Homo sapiens
10 CTDSP1 58190
Affinity Capture-MS Homo sapiens
11 ALDH4A1 8659
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
12 MTIF2 4528
Proximity Label-MS Homo sapiens
13 MSRB2  
Co-fractionation Homo sapiens
14 MDH2 4191
Proximity Label-MS Homo sapiens
15 CLPP 8192
Proximity Label-MS Homo sapiens
16 LONP1 9361
Proximity Label-MS Homo sapiens
17 CD300E  
Affinity Capture-MS Homo sapiens
18 ANXA7 310
Co-fractionation Homo sapiens
19 PDHA1 5160
Proximity Label-MS Homo sapiens
20 C6orf203  
Proximity Label-MS Homo sapiens
21 COX8A  
Proximity Label-MS Homo sapiens
22 TST 7263
Co-fractionation Homo sapiens
23 PEBP1 5037
Co-fractionation Homo sapiens
24 FAH 2184
Co-fractionation Homo sapiens
25 C21orf33  
Proximity Label-MS Homo sapiens
26 SSBP1 6742
Proximity Label-MS Homo sapiens
27 CCDC90B  
Proximity Label-MS Homo sapiens
28 SH3BGRL3 83442
Co-fractionation Homo sapiens
29 LRPPRC 10128
Proximity Label-MS Homo sapiens
30 PMPCB 9512
Proximity Label-MS Homo sapiens
31 IDH2 3418
Co-fractionation Homo sapiens
32 SEC14L2  
Co-fractionation Homo sapiens
33 NQO1 1728
Co-fractionation Homo sapiens
34 GFM1 85476
Proximity Label-MS Homo sapiens
35 AARS2  
Proximity Label-MS Homo sapiens
36 BTF3 689
Affinity Capture-MS Homo sapiens
37 PTRHD1 391356
Co-fractionation Homo sapiens
38 CT55  
Two-hybrid Homo sapiens
39 TBRG4 9238
Proximity Label-MS Homo sapiens
40 C1QBP 708
Proximity Label-MS Homo sapiens
41 DSTN 11034
Co-fractionation Homo sapiens
42 HINT2 84681
Proximity Label-MS Homo sapiens
43 HMGCL 3155
Co-fractionation Homo sapiens
44 SERBP1 26135
Affinity Capture-MS Homo sapiens
45 HINT1 3094
Co-fractionation Homo sapiens
46 AK1 203
Co-fractionation Homo sapiens
47 MB  
Co-fractionation Homo sapiens
48 INHBA 3624
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which LYPLAL1 is involved
No pathways found





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