Gene description for Dmbt1
Gene name deleted in malignant brain tumors 1
Gene symbol Dmbt1
Other names/aliases CRP
CRP-[a]
CRP-[b]
Crpd
DBMT1
gp300
p80
Species Mus musculus
 Database cross references - Dmbt1
ExoCarta ExoCarta_12945
Vesiclepedia VP_12945
Entrez Gene 12945
UniProt Q60997  
 Dmbt1 identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Dmbt1
Molecular Function
    lipopolysaccharide binding GO:0001530 ISO
    DNA binding GO:0003677 ISO
    scavenger receptor activity GO:0005044 ISO
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    zymogen binding GO:0035375 IDA
    pattern recognition receptor activity GO:0038187 ISO
    lipoteichoic acid binding GO:0070891 ISO
    heparan sulfate binding GO:1904399 ISO
Biological Process
    blastocyst development GO:0001824 IMP
    inner cell mass cell proliferation GO:0001833 IDA
    columnar/cuboidal epithelial cell differentiation GO:0002065 IDA
    receptor-mediated endocytosis GO:0006898 ISO
    defense response GO:0006952 IBA
    response to bacterium GO:0009617 IEP
    protein transport GO:0015031 IEA
    positive regulation of epithelial cell differentiation GO:0030858 IDA
    induction of bacterial agglutination GO:0043152 ISO
    defense response to Gram-negative bacterium GO:0050829 IDA
    defense response to Gram-negative bacterium GO:0050829 ISO
    defense response to Gram-positive bacterium GO:0050830 IDA
    defense response to Gram-positive bacterium GO:0050830 ISO
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 ISO
    intracellular anatomical structure GO:0005622 IDA
    cytoplasm GO:0005737 ISO
    transport vesicle membrane GO:0030658 IEA
    phagocytic vesicle membrane GO:0030670 ISO
    extracellular matrix GO:0031012 IBA
    extracellular matrix GO:0031012 IDA
    zymogen granule membrane GO:0042589 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 ISO
 Experiment description of studies that identified Dmbt1 in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Dmbt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ctsg  
Co-fractionation Mus musculus
2 Defa26  
Co-fractionation Mus musculus
3 Cdk6 12571
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Dmbt1 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Surfactant metabolism IEA Reactome





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