Gene description for CD200R1
Gene name CD200 receptor 1
Gene symbol CD200R1
Other names/aliases CD200R
HCRTR2
MOX2R
OX2R
Species Homo sapiens
 Database cross references - CD200R1
ExoCarta ExoCarta_131450
Vesiclepedia VP_131450
Entrez Gene 131450
HGNC 24235
MIM 607546
UniProt Q8TD46  
 CD200R1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CD200R1
Molecular Function
    protein binding GO:0005515 IPI
    immunoglobulin receptor activity GO:0019763 TAS
    signaling receptor activity GO:0038023 IBA
    glycosylated region protein binding GO:0140081 TAS
Biological Process
    signal transduction GO:0007165 TAS
    negative regulation of interleukin-6 production GO:0032715 ISS
    heterotypic cell-cell adhesion GO:0034113 ISS
    intracellular signal transduction GO:0035556 TAS
    Fc receptor signaling pathway GO:0038093 IEA
    regulation of neuroinflammatory response GO:0150077 ISS
    negative regulation of neuroinflammatory response GO:0150079 ISS
    negative regulation of macrophage migration GO:1905522 ISS
    negative regulation of T cell migration GO:2000405 ISS
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISS
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified CD200R1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CD200R1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TCP10L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 POMT2  
Affinity Capture-MS Homo sapiens
3 MBOAT7 79143
Affinity Capture-MS Homo sapiens
4 COL1A1 1277
Affinity Capture-MS Homo sapiens
5 PVR 5817
Affinity Capture-MS Homo sapiens
6 GALNT15  
Two-hybrid Homo sapiens
7 SGTB  
Two-hybrid Homo sapiens
8 CLDN19  
Two-hybrid Homo sapiens
9 NINJ1 4814
Two-hybrid Homo sapiens
10 TNPO2 30000
Affinity Capture-MS Homo sapiens
11 ADIPOQ 9370
Two-hybrid Homo sapiens
12 MAGEB3  
Affinity Capture-MS Homo sapiens
13 FUT8 2530
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CD200 4345
Reconstituted Complex Homo sapiens
15 PTCH1  
Two-hybrid Homo sapiens
16 SEZ6L2 26470
Affinity Capture-MS Homo sapiens
17 ULBP3 79465
Affinity Capture-MS Homo sapiens
18 SFTPC  
Two-hybrid Homo sapiens
19 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
20 PCDH1 5097
Affinity Capture-MS Homo sapiens
21 TNFSF9  
Affinity Capture-MS Homo sapiens
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