Gene description for Fkbp1a
Gene name FK506 binding protein 1a
Gene symbol Fkbp1a
Other names/aliases FKBP12
Fkbp
Fkbp1
Species Mus musculus
 Database cross references - Fkbp1a
ExoCarta ExoCarta_14225
Vesiclepedia VP_14225
Entrez Gene 14225
UniProt P26883  
 Fkbp1a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fkbp1a
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISO
    transforming growth factor beta receptor binding GO:0005160 ISO
    protein binding GO:0005515 IPI
    FK506 binding GO:0005528 IDA
    FK506 binding GO:0005528 ISO
    channel regulator activity GO:0016247 ISO
    enzyme binding GO:0019899 ISO
    Hsp70 protein binding GO:0030544 ISO
    signaling receptor inhibitor activity GO:0030547 ISO
    type I transforming growth factor beta receptor binding GO:0034713 ISO
    identical protein binding GO:0042802 IPI
    transmembrane transporter binding GO:0044325 IPI
    I-SMAD binding GO:0070411 ISO
    activin receptor binding GO:0070697 ISO
    RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA
    RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA
Biological Process
    heart morphogenesis GO:0003007 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    muscle contraction GO:0006936 IMP
    cytokine-mediated signaling pathway GO:0019221 IMP
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IBA
    response to caffeine GO:0031000 IMP
    negative regulation of activin receptor signaling pathway GO:0032926 IBA
    T cell proliferation GO:0042098 IMP
    release of sequestered calcium ion into cytosol GO:0051209 IDA
    release of sequestered calcium ion into cytosol GO:0051209 IMP
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 IMP
    heart trabecula formation GO:0060347 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    sarcoplasmic reticulum GO:0016529 ISS
    Z disc GO:0030018 ISO
    sarcoplasmic reticulum membrane GO:0033017 IBA
    sarcoplasmic reticulum membrane GO:0033017 IDA
    axon terminus GO:0043679 ISO
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
    cytoplasmic side of membrane GO:0098562 ISS
    ryanodine receptor complex GO:1990425 ISS
 Experiment description of studies that identified Fkbp1a in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fkbp1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BMPR1B 658
Affinity Capture-Luminescence Homo sapiens
2 Eed  
Affinity Capture-MS Mus musculus
3 TGFBR1 7046
Affinity Capture-Luminescence Homo sapiens
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