Gene description for BMPR1B
Gene name bone morphogenetic protein receptor, type IB
Gene symbol BMPR1B
Other names/aliases ALK-6
ALK6
CDw293
Species Homo sapiens
 Database cross references - BMPR1B
ExoCarta ExoCarta_658
Vesiclepedia VP_658
Entrez Gene 658
HGNC 1077
MIM 603248
UniProt O00238  
 BMPR1B identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BMPR1B
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IDA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 NAS
    transmembrane signaling receptor activity GO:0004888 IDA
    transforming growth factor beta receptor activity, type I GO:0005025 IBA
    transforming growth factor beta receptor activity, type II GO:0005026 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    activin receptor activity, type I GO:0016361 IEA
    activin receptor activity, type II GO:0016362 IEA
    BMP binding GO:0036122 IPI
    SMAD binding GO:0046332 IDA
    metal ion binding GO:0046872 IEA
    transforming growth factor beta receptor activity, type III GO:0070123 IEA
    BMP receptor activity GO:0098821 IDA
Biological Process
    cartilage condensation GO:0001502 IEA
    ovarian cumulus expansion GO:0001550 ISS
    osteoblast differentiation GO:0001649 IMP
    eye development GO:0001654 ISS
    chondrocyte development GO:0002063 ISS
    inflammatory response GO:0006954 IEA
    dorsal/ventral pattern formation GO:0009953 IBA
    positive regulation of gene expression GO:0010628 IMP
    central nervous system neuron differentiation GO:0021953 IEA
    cell differentiation GO:0030154 IBA
    proteoglycan biosynthetic process GO:0030166 ISS
    positive regulation of bone mineralization GO:0030501 IMP
    BMP signaling pathway GO:0030509 IBA
    BMP signaling pathway GO:0030509 IDA
    BMP signaling pathway GO:0030509 NAS
    retinal ganglion cell axon guidance GO:0031290 IEA
    positive regulation of chondrocyte differentiation GO:0032332 ISS
    activin receptor signaling pathway GO:0032924 IEA
    ovulation cycle GO:0042698 ISS
    positive regulation of osteoblast differentiation GO:0045669 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    retina development in camera-type eye GO:0060041 IEA
    endochondral bone morphogenesis GO:0060350 ISS
    positive regulation of cartilage development GO:0061036 ISS
    cellular response to growth factor stimulus GO:0071363 IBA
    cellular response to BMP stimulus GO:0071773 IMP
    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 IEA
    negative regulation of chondrocyte proliferation GO:1902731 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    receptor complex GO:0043235 IBA
    receptor complex GO:0043235 TAS
    HFE-transferrin receptor complex GO:1990712 IC
 Experiment description of studies that identified BMPR1B in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BMPR1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps27a 78294
Affinity Capture-Luminescence Mus musculus
2 TPRA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 Rab6b  
Affinity Capture-Luminescence Mus musculus
4 Map2k3  
Affinity Capture-Luminescence Mus musculus
5 Srgap1  
Affinity Capture-Luminescence Mus musculus
6 BMP2  
Reconstituted Complex Homo sapiens
7 XIAP  
Affinity Capture-Western Homo sapiens
8 Ppp3cc  
Affinity Capture-Luminescence Mus musculus
9 Cdk14  
Affinity Capture-Luminescence Mus musculus
10 Dcaf7  
Affinity Capture-Luminescence Mus musculus
11 Stk35  
Affinity Capture-Luminescence Mus musculus
12 Usp45  
Affinity Capture-Luminescence Mus musculus
13 Sh3kbp1 58194
Affinity Capture-Luminescence Mus musculus
14 SMURF1 57154
Affinity Capture-Western Homo sapiens
15 USP15 9958
Affinity Capture-Western Homo sapiens
16 IGSF1  
Affinity Capture-Western Homo sapiens
17 Rhebl1  
Affinity Capture-Luminescence Mus musculus
18 Fkbp1b  
Affinity Capture-Luminescence Mus musculus
19 Uhmk1  
Affinity Capture-Luminescence Mus musculus
20 Ilkap  
Affinity Capture-Luminescence Mus musculus
21 Bcr  
Affinity Capture-Luminescence Mus musculus
22 Stub1 56424
Affinity Capture-Luminescence Mus musculus
23 Smad7  
Affinity Capture-Luminescence Mus musculus
24 Cdk4  
Affinity Capture-Luminescence Mus musculus
25 TRAF6 7189
Affinity Capture-Western Homo sapiens
26 Arhgef6  
Affinity Capture-Luminescence Mus musculus
27 Naa20  
Affinity Capture-Luminescence Mus musculus
28 Atg16l1  
Affinity Capture-Luminescence Mus musculus
29 BMPR1A 657
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
30 Irf7  
Affinity Capture-Luminescence Mus musculus
31 Fbxo34  
Affinity Capture-Luminescence Mus musculus
32 Mknk2  
Affinity Capture-Luminescence Mus musculus
33 Nkiras1  
Affinity Capture-Luminescence Mus musculus
34 Rhoj  
Affinity Capture-Luminescence Mus musculus
35 GDF6 392255
Reconstituted Complex Homo sapiens
36 SNX6 58533
Affinity Capture-Western Homo sapiens
37 APP 351
Reconstituted Complex Homo sapiens
38 Rras2 66922
Affinity Capture-Luminescence Mus musculus
39 Rab38  
Affinity Capture-Luminescence Mus musculus
40 EVA1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 Klhl1  
Affinity Capture-Luminescence Mus musculus
42 Ppp2ca 19052
Affinity Capture-Luminescence Mus musculus
43 Tgfbr1 21812
Affinity Capture-Luminescence Mus musculus
44 Fbxo3  
Affinity Capture-Luminescence Mus musculus
45 Rasd2  
Affinity Capture-Luminescence Mus musculus
46 BMPR1B 658
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 MKRN2 23609
Affinity Capture-RNA Homo sapiens
48 BMPR2 659
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
49 Rhobtb1  
Affinity Capture-Luminescence Mus musculus
50 Bmpr2 12168
Affinity Capture-Luminescence Mus musculus
51 Smad6  
Affinity Capture-Luminescence Mus musculus
52 Nedd4 25489
Biochemical Activity Rattus norvegicus
53 Lztr1  
Affinity Capture-Luminescence Mus musculus
54 Rap2a  
Affinity Capture-Luminescence Mus musculus
55 Rhod  
Affinity Capture-Luminescence Mus musculus
56 BMP7 655
Reconstituted Complex Homo sapiens
57 TSC22D1 8848
Affinity Capture-Western Homo sapiens
58 BAMBI  
Reconstituted Complex Homo sapiens
59 Sqstm1  
Affinity Capture-Luminescence Mus musculus
60 Fancl  
Affinity Capture-Luminescence Mus musculus
61 Chn1  
Affinity Capture-Luminescence Mus musculus
62 SMAD6  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 Fkbp1a 14225
Affinity Capture-Luminescence Mus musculus
64 HADHB 3032
Cross-Linking-MS (XL-MS) Homo sapiens
65 Fbxw5  
Affinity Capture-Luminescence Mus musculus
66 1700006A11Rik 71824
Affinity Capture-Luminescence Mus musculus
67 BMP4 652
Reconstituted Complex Homo sapiens
68 Plekhb1  
Affinity Capture-Luminescence Mus musculus
69 GDF5 8200
Reconstituted Complex Homo sapiens
70 RGMB  
Affinity Capture-Western Homo sapiens
71 OTUB1 55611
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which BMPR1B is involved
PathwayEvidenceSource
Signal Transduction TAS Reactome
Signaling by BMP TAS Reactome
Signaling by TGFB family members TAS Reactome





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