Gene description for SLC30A7
Gene name solute carrier family 30 (zinc transporter), member 7
Gene symbol SLC30A7
Other names/aliases ZNT7
ZnT-7
ZnTL2
Species Homo sapiens
 Database cross references - SLC30A7
ExoCarta ExoCarta_148867
Vesiclepedia VP_148867
Entrez Gene 148867
HGNC 19306
MIM 611149
UniProt Q8NEW0  
 SLC30A7 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC30A7
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    intracellular zinc ion homeostasis GO:0006882 IBA
    zinc ion import into Golgi lumen GO:1904257 IBA
    zinc ion import into Golgi lumen GO:1904257 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 ISS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytoplasmic vesicle GO:0031410 IBA
    vesicle GO:0031982 IDA
    sarcoplasmic reticulum membrane GO:0033017 ISS
    perinuclear region of cytoplasm GO:0048471 IEA
    Golgi cis cisterna membrane GO:1990674 IDA
 Experiment description of studies that identified SLC30A7 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC30A7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZRANB1 54764
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 CD40 958
Affinity Capture-MS Homo sapiens
4 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 VIPR2  
Affinity Capture-MS Homo sapiens
6 ADORA2B  
Affinity Capture-MS Homo sapiens
7 EDNRA 1909
Affinity Capture-MS Homo sapiens
8 RIC3  
Affinity Capture-MS Homo sapiens
9 DHCR24 1718
Affinity Capture-MS Homo sapiens
10 LAMP3  
Proximity Label-MS Homo sapiens
11 NUP155 9631
Proximity Label-MS Homo sapiens
12 B3GNT3 10331
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CHRNA1  
Affinity Capture-MS Homo sapiens
14 CRELD1 78987
Affinity Capture-MS Homo sapiens
15 P2RY2 5029
Affinity Capture-MS Homo sapiens
16 ST3GAL1 6482
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TSPAN15 23555
Affinity Capture-MS Homo sapiens
18 GJD3  
Proximity Label-MS Homo sapiens
19 SLC34A2 10568
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 LAMP2 3920
Proximity Label-MS Homo sapiens
21 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
22 KLRD1  
Affinity Capture-MS Homo sapiens
23 WBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 KATNA1 11104
Affinity Capture-MS Homo sapiens
25 YIPF5 81555
Affinity Capture-MS Homo sapiens
26 P2RY8  
Affinity Capture-MS Homo sapiens
27 FFAR1  
Affinity Capture-MS Homo sapiens
28 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GPR35  
Affinity Capture-MS Homo sapiens
30 CD27  
Affinity Capture-MS Homo sapiens
31 MRPL1  
Affinity Capture-MS Homo sapiens
32 KCNE3  
Affinity Capture-MS Homo sapiens
33 DNAJC5 80331
Affinity Capture-MS Homo sapiens
34 C12orf49  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 TSPAN8 7103
Affinity Capture-MS Homo sapiens
36 B3GAT1  
Proximity Label-MS Homo sapiens
37 PCDH10 57575
Affinity Capture-MS Homo sapiens
38 LYPD6  
Affinity Capture-MS Homo sapiens
39 CHRNA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 SPPL2B 56928
Affinity Capture-MS Homo sapiens
41 GPR45  
Affinity Capture-MS Homo sapiens
42 RAB7A 7879
Proximity Label-MS Homo sapiens
43 LPAR2 9170
Affinity Capture-MS Homo sapiens
44 WNT5A 7474
Affinity Capture-MS Homo sapiens
45 CLPSL1  
Affinity Capture-MS Homo sapiens
46 CLEC2B  
Affinity Capture-MS Homo sapiens
47 VIPR1  
Affinity Capture-MS Homo sapiens
48 B3GAT3 26229
Affinity Capture-MS Homo sapiens
49 TMEM63A 9725
Affinity Capture-MS Homo sapiens
50 DNAJC5B  
Affinity Capture-MS Homo sapiens
51 ADGRE5 976
Affinity Capture-MS Homo sapiens
52 UST  
Affinity Capture-MS Homo sapiens
53 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RPA3 6119
Proximity Label-MS Homo sapiens
55 CLEC4E  
Affinity Capture-MS Homo sapiens
56 GPR173  
Affinity Capture-MS Homo sapiens
57 PDE3A  
Affinity Capture-MS Homo sapiens
58 P2RY12 64805
Affinity Capture-MS Homo sapiens
59 S1PR4  
Affinity Capture-MS Homo sapiens
60 ATP2A1 487
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC30A7 is involved
No pathways found





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