Gene description for CYP2D6
Gene name	cytochrome P450, family 2, subfamily D, polypeptide 6
Gene symbol	CYP2D6
Other names/aliases	CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1
Species	Homo sapiens
Database cross references - CYP2D6
ExoCarta	ExoCarta_1565
Vesiclepedia	VP_1565
Entrez Gene	1565
HGNC	2625
MIM	124030
UniProt	P10635
CYP2D6 identified in sEVs derived from the following tissue/cell type
Urine	21595033
Urine	21595033
Urine	21595033

Gene ontology annotations for CYP2D6

Molecular Function     monooxygenase activity GO:0004497 IDA     monooxygenase activity GO:0004497 TAS     iron ion binding GO:0005506 IEA     oxidoreductase activity GO:0016491 IDA     oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IBA     oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 TAS     heme binding GO:0020037 IBA     heme binding GO:0020037 IDA     anandamide 8,9 epoxidase activity GO:0062187 IDA     anandamide 11,12 epoxidase activity GO:0062188 IDA     anandamide 14,15 epoxidase activity GO:0062189 IDA Biological Process     xenobiotic metabolic process GO:0006805 IBA     xenobiotic metabolic process GO:0006805 IDA     xenobiotic metabolic process GO:0006805 IMP     xenobiotic metabolic process GO:0006805 TAS     steroid metabolic process GO:0008202 IMP     cholesterol metabolic process GO:0008203 IEA     estrogen metabolic process GO:0008210 IDA     coumarin metabolic process GO:0009804 IDA     alkaloid metabolic process GO:0009820 IDA     alkaloid catabolic process GO:0009822 IDA     monoterpenoid metabolic process GO:0016098 IDA     arachidonate metabolic process GO:0019369 IBA     isoquinoline alkaloid metabolic process GO:0033076 IDA     xenobiotic catabolic process GO:0042178 IDA     retinol metabolic process GO:0042572 IDA     retinol metabolic process GO:0042572 IEA     long-chain fatty acid biosynthetic process GO:0042759 TAS     negative regulation of binding GO:0051100 IDA     oxidative demethylation GO:0070989 IDA     negative regulation of organofluorine metabolic process GO:0090350 IDA Subcellular Localization     cytoplasm GO:0005737 IBA     mitochondrion GO:0005739 IDA     endoplasmic reticulum GO:0005783 TAS     endoplasmic reticulum membrane GO:0005789 TAS     intracellular membrane-bounded organelle GO:0043231 IBA