Gene description for Igf2r
Gene name insulin-like growth factor 2 receptor
Gene symbol Igf2r
Other names/aliases AI661837
CD222
CI-MPR
M6P/IGF2R
Mpr300
Species Mus musculus
 Database cross references - Igf2r
ExoCarta ExoCarta_16004
Vesiclepedia VP_16004
Entrez Gene 16004
UniProt Q07113  
 Igf2r identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Igf2r
Molecular Function
    G-protein alpha-subunit binding GO:0001965 IEA
    G-protein alpha-subunit binding GO:0001965 ISO
    retinoic acid binding GO:0001972 IEA
    retinoic acid binding GO:0001972 ISO
    protein binding GO:0005515 IPI
    protein binding GO:0005515 ISS
    insulin-like growth factor binding GO:0005520 IBA
    insulin-like growth factor binding GO:0005520 IPI
    D-mannose binding GO:0005537 IDA
    enzyme binding GO:0019899 IEA
    enzyme binding GO:0019899 ISO
    insulin-like growth factor II binding GO:0031995 IEA
    insulin-like growth factor II binding GO:0031995 ISO
    signaling receptor activity GO:0038023 IEA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    phosphoprotein binding GO:0051219 ISO
    phosphoprotein binding GO:0051219 ISS
    retromer complex binding GO:1905394 IEA
    retromer complex binding GO:1905394 ISO
Biological Process
    liver development GO:0001889 IEA
    liver development GO:0001889 ISO
    lysosomal transport GO:0007041 IBA
    lysosomal transport GO:0007041 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    G protein-coupled receptor signaling pathway GO:0007186 ISO
    spermatogenesis GO:0007283 IEA
    post-embryonic development GO:0009791 IEA
    animal organ regeneration GO:0031100 IEA
    response to retinoic acid GO:0032526 IEA
    response to retinoic acid GO:0032526 ISO
    regulation of apoptotic process GO:0042981 ISO
    positive regulation of apoptotic process GO:0043065 IEA
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation by host of viral process GO:0044794 IEA
    positive regulation by host of viral process GO:0044794 ISO
    response to tetrachloromethane GO:1904772 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 IDA
    nuclear envelope lumen GO:0005641 IDA
    endosome GO:0005768 ISO
    early endosome GO:0005769 IEA
    early endosome GO:0005769 ISO
    late endosome GO:0005770 IBA
    late endosome GO:0005770 ISO
    Golgi apparatus GO:0005794 ISO
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IEA
    trans-Golgi network GO:0005802 ISO
    plasma membrane GO:0005886 IBA
    cell surface GO:0009986 ISO
    cell surface GO:0009986 ISS
    endosome membrane GO:0010008 IEA
    endosome membrane GO:0010008 ISO
    membrane GO:0016020 IDA
    clathrin coat GO:0030118 IEA
    clathrin coat GO:0030118 ISO
    endocytic vesicle GO:0030139 ISO
    endocytic vesicle GO:0030139 ISS
    trans-Golgi network transport vesicle GO:0030140 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Igf2r in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Igf2r
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tsc1  
Affinity Capture-MS Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Ctsd 13033
Affinity Capture-Western Mus musculus
4 Atg5  
Affinity Capture-MS Mus musculus
5 Shank3  
Affinity Capture-MS Mus musculus
6 Eea1  
Co-fractionation Mus musculus
7 Iqcb1  
Affinity Capture-MS Mus musculus
8 Fancd2  
Affinity Capture-MS Mus musculus
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