Gene description for Il1rap
Gene name interleukin 1 receptor accessory protein
Gene symbol Il1rap
Other names/aliases 6430709H04Rik
AI255955
AV239853
IL-1RAcP
Species Mus musculus
 Database cross references - Il1rap
ExoCarta ExoCarta_16180
Vesiclepedia VP_16180
Entrez Gene 16180
UniProt Q61730  
 Il1rap identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Il1rap
Molecular Function
    interleukin-33 receptor activity GO:0002114 IMP
    NAD+ nucleosidase activity GO:0003953 IEA
    interleukin-1 receptor activity GO:0004908 IBA
    interleukin-1 receptor activity GO:0004908 IDA
    interleukin-1 receptor binding GO:0005149 ISO
    protein binding GO:0005515 IPI
    coreceptor activity GO:0015026 IEA
    coreceptor activity GO:0015026 ISO
    NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 IEA
Biological Process
    inflammatory response GO:0006954 IEA
    cytokine-mediated signaling pathway GO:0019221 IBA
    cytokine-mediated signaling pathway GO:0019221 IDA
    interleukin-2 production GO:0032623 IDA
    positive regulation of interleukin-13 production GO:0032736 IMP
    positive regulation of interleukin-4 production GO:0032753 IMP
    positive regulation of interleukin-5 production GO:0032754 IMP
    positive regulation of interleukin-6 production GO:0032755 IMP
    interleukin-33-mediated signaling pathway GO:0038172 IMP
    interleukin-33-mediated signaling pathway GO:0038172 ISO
    innate immune response GO:0045087 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    positive regulation of synapse assembly GO:0051965 IDA
    interleukin-1-mediated signaling pathway GO:0070498 IEA
    interleukin-1-mediated signaling pathway GO:0070498 ISO
    regulation of postsynaptic density assembly GO:0099151 IDA
    regulation of postsynaptic density assembly GO:0099151 IMP
    trans-synaptic signaling by trans-synaptic complex GO:0099545 IDA
    trans-synaptic signaling by trans-synaptic complex GO:0099545 IMP
    synaptic membrane adhesion GO:0099560 IDA
    synaptic membrane adhesion GO:0099560 IMP
    regulation of presynapse assembly GO:1905606 IDA
    regulation of presynapse assembly GO:1905606 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    cell surface GO:0009986 IBA
    protein-containing complex GO:0032991 ISO
    synapse GO:0045202 IDA
    synapse GO:0045202 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Il1rap in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Il1rap
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tollip 54473
Co-fractionation Mus musculus
2 Stat3 20848
Co-fractionation Mus musculus
3 Il1r1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
4 MYD88 4615
Affinity Capture-Western Homo sapiens
5 Irak1  
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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