Gene description for ZFPM1
Gene name zinc finger protein, FOG family member 1
Gene symbol ZFPM1
Other names/aliases FOG
FOG1
ZC2HC11A
ZNF408
ZNF89A
Species Homo sapiens
 Database cross references - ZFPM1
ExoCarta ExoCarta_161882
Vesiclepedia VP_161882
Entrez Gene 161882
HGNC 19762
MIM 601950
UniProt Q8IX07  
 ZFPM1 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for ZFPM1
Molecular Function
    DNA binding GO:0003677 IEA
    transcription corepressor activity GO:0003714 IGI
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IGI
    T-helper cell lineage commitment GO:0002295 IC
    outflow tract morphogenesis GO:0003151 ISS
    atrioventricular valve morphogenesis GO:0003181 ISS
    mitral valve formation GO:0003192 ISS
    tricuspid valve formation GO:0003195 ISS
    heart development GO:0007507 IBA
    regulation of definitive erythrocyte differentiation GO:0010724 IDA
    regulation of definitive erythrocyte differentiation GO:0010724 IMP
    erythrocyte differentiation GO:0030218 IBA
    erythrocyte differentiation GO:0030218 ISS
    megakaryocyte differentiation GO:0030219 IBA
    megakaryocyte differentiation GO:0030219 ISS
    platelet formation GO:0030220 IGI
    granulocyte differentiation GO:0030851 IEA
    negative regulation of protein binding GO:0032091 ISS
    regulation of chemokine production GO:0032642 IEA
    negative regulation of interleukin-4 production GO:0032713 IDA
    positive regulation of type II interferon production GO:0032729 IDA
    embryonic hemopoiesis GO:0035162 ISS
    megakaryocyte development GO:0035855 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    cardiac muscle tissue morphogenesis GO:0055008 ISS
    definitive erythrocyte differentiation GO:0060318 IEA
    primitive erythrocyte differentiation GO:0060319 IEA
    negative regulation of mast cell differentiation GO:0060377 ISS
    ventricular septum morphogenesis GO:0060412 ISS
    atrial septum morphogenesis GO:0060413 ISS
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IDA
    transcription repressor complex GO:0017053 IDA
 Experiment description of studies that identified ZFPM1 in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZFPM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 ERP44 23071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GATA2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 Rb1  
Affinity Capture-Western Mus musculus
5 TRIM21 6737
Affinity Capture-Western Homo sapiens
6 GSK3B 2932
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
7 DEFA6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RBBP4 5928
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
9 MTA1 9112
Co-crystal Structure Homo sapiens
10 CTBP2 1488
Two-hybrid Homo sapiens
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