Gene description for Kif2a
Gene name kinesin family member 2A
Gene symbol Kif2a
Other names/aliases C530030B14Rik
Kif2
Kns2
M-kinesin
Species Mus musculus
 Database cross references - Kif2a
ExoCarta ExoCarta_16563
Vesiclepedia VP_16563
Entrez Gene 16563
UniProt P28740  
 Kif2a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Kif2a
Molecular Function
    microtubule motor activity GO:0003777 IBA
    microtubule motor activity GO:0003777 IEA
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 IEA
    microtubule binding GO:0008017 ISO
    ATP hydrolysis activity GO:0016887 IBA
    protein kinase binding GO:0019901 ISO
Biological Process
    microtubule cytoskeleton organization GO:0000226 ISO
    microtubule-based movement GO:0007018 IBA
    mitotic spindle organization GO:0007052 ISO
    mitotic spindle organization GO:0007052 ISS
    nervous system development GO:0007399 IEA
    cell differentiation GO:0030154 IEA
    regulation of cell migration GO:0030334 ISO
    cell division GO:0051301 IEA
    mitotic spindle assembly GO:0090307 ISO
    mitotic spindle assembly GO:0090307 ISS
    dendritic transport GO:0098935 IDA
    dendritic transport GO:0098935 IMP
Subcellular Localization
    spindle pole GO:0000922 ISO
    spindle pole GO:0000922 ISS
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    lysosome GO:0005764 IEA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    spindle GO:0005819 IBA
    kinesin complex GO:0005871 IBA
    microtubule GO:0005874 IBA
    microtubule GO:0005874 ISO
    spindle microtubule GO:0005876 ISO
    spindle microtubule GO:0005876 ISS
    nuclear body GO:0016604 ISO
    dendrite GO:0030425 IEA
    sperm principal piece GO:0097228 IDA
    GABA-ergic synapse GO:0098982 IDA
    GABA-ergic synapse GO:0098982 IMP
 Experiment description of studies that identified Kif2a in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Kif2a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dnm1 13429
Affinity Capture-Western Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Fxr1 14359
Affinity Capture-MS Mus musculus
4 Tnik  
Affinity Capture-MS Mus musculus
5 ARHGEF17 9828
Affinity Capture-MS Homo sapiens
6 Fmr1  
Affinity Capture-MS Mus musculus
7 Cyfip1 20430
Affinity Capture-MS Mus musculus
8 Hdac1 433759
Affinity Capture-Western Mus musculus
9 Pde4dip  
Affinity Capture-MS Mus musculus
10 GMDS 2762
Affinity Capture-MS Homo sapiens
11 Dlg4  
Affinity Capture-MS Mus musculus
12 ORMDL1 94101
Affinity Capture-MS Homo sapiens
13 SNRNP48  
Two-hybrid Homo sapiens
14 LARP4 113251
Affinity Capture-MS Homo sapiens
15 KIF2C 11004
Affinity Capture-MS Homo sapiens
16 Ywhaz 22631
Affinity Capture-MS Mus musculus
17 Dlgap1  
Affinity Capture-MS Mus musculus
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