Gene description for Xpnpep1
Gene name X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Gene symbol Xpnpep1
Other names/aliases D230045I08Rik
sAMP
Species Mus musculus
 Database cross references - Xpnpep1
ExoCarta ExoCarta_170750
Vesiclepedia VP_170750
Entrez Gene 170750
UniProt Q6P1B1  
 Xpnpep1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Xpnpep1
Molecular Function
    aminopeptidase activity GO:0004177 ISO
    aminopeptidase activity GO:0004177 ISS
    manganese ion binding GO:0030145 ISO
    manganese ion binding GO:0030145 ISS
    protein homodimerization activity GO:0042803 ISO
    metalloaminopeptidase activity GO:0070006 ISO
    metalloaminopeptidase activity GO:0070006 ISS
Biological Process
    proteolysis GO:0006508 ISO
    proteolysis GO:0006508 ISS
    bradykinin catabolic process GO:0010815 ISO
    bradykinin catabolic process GO:0010815 ISS
    negative regulation of programmed cell death GO:0043069 ISO
    negative regulation of programmed cell death GO:0043069 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Xpnpep1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Xpnpep1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pde12  
Co-fractionation Mus musculus
2 Uba6 231380
Co-fractionation Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Gnpda1  
Co-fractionation Mus musculus
5 Fancd2  
Affinity Capture-MS Mus musculus
6 Pygb 110078
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Xpnpep1 is involved
No pathways found





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