Gene description for Abcc1
Gene name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Gene symbol Abcc1
Other names/aliases Abcc1a
Abcc1b
MRP
Mdrap
Mrp1
Species Mus musculus
 Database cross references - Abcc1
ExoCarta ExoCarta_17250
Vesiclepedia VP_17250
Entrez Gene 17250
UniProt O35379  
 Abcc1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Abcc1
Molecular Function
    long-chain fatty acid transmembrane transporter activity GO:0005324 IEA
    long-chain fatty acid transmembrane transporter activity GO:0005324 ISO
    ATP binding GO:0005524 IEA
    ABC-type xenobiotic transporter activity GO:0008559 IBA
    ABC-type xenobiotic transporter activity GO:0008559 IEA
    ABC-type xenobiotic transporter activity GO:0008559 ISO
    ABC-type vitamin B12 transporter activity GO:0015420 IMP
    ABC-type vitamin B12 transporter activity GO:0015420 ISO
    ABC-type glutathione S-conjugate transporter activity GO:0015431 IMP
    efflux transmembrane transporter activity GO:0015562 IMP
    efflux transmembrane transporter activity GO:0015562 ISO
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled lipid transmembrane transporter activity GO:0034040 IEA
    ATPase-coupled lipid transmembrane transporter activity GO:0034040 ISO
    glutathione transmembrane transporter activity GO:0034634 IBA
    glutathione transmembrane transporter activity GO:0034634 IMP
    glutathione transmembrane transporter activity GO:0034634 ISO
    amide transmembrane transporter activity GO:0042887 ISO
    xenobiotic transmembrane transporter activity GO:0042910 IMP
    xenobiotic transmembrane transporter activity GO:0042910 ISO
    xenobiotic transmembrane transporter activity GO:0042910 ISS
    carboxylic acid transmembrane transporter activity GO:0046943 ISO
    ABC-type transporter activity GO:0140359 ISO
    ABC-type transporter activity GO:0140359 ISS
Biological Process
    response to oxidative stress GO:0006979 IEA
    response to oxidative stress GO:0006979 ISO
    response to xenobiotic stimulus GO:0009410 IMP
    response to xenobiotic stimulus GO:0009410 ISO
    glial cell differentiation GO:0010001 ISO
    cobalamin transport GO:0015889 IMP
    long-chain fatty acid import across plasma membrane GO:0015911 IEA
    long-chain fatty acid import across plasma membrane GO:0015911 ISO
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    phospholipid efflux GO:0033700 IEA
    phospholipid efflux GO:0033700 ISO
    glutathione transmembrane transport GO:0034775 IBA
    glutathione transmembrane transport GO:0034775 IEA
    glutathione transmembrane transport GO:0034775 ISO
    xenobiotic transport GO:0042908 IBA
    xenobiotic transport GO:0042908 IMP
    xenobiotic transport GO:0042908 ISO
    phospholipid translocation GO:0045332 IEA
    phospholipid translocation GO:0045332 ISO
    astrocyte differentiation GO:0048708 IEA
    astrocyte differentiation GO:0048708 ISO
    positive regulation of inflammatory response GO:0050729 IMP
    transmembrane transport GO:0055085 ISO
    cell chemotaxis GO:0060326 IEA
    cell chemotaxis GO:0060326 ISO
    transepithelial transport GO:0070633 IEA
    transepithelial transport GO:0070633 ISO
    cyclic nucleotide transport GO:0070729 IMP
    cyclic nucleotide transport GO:0070729 ISO
    leukotriene transport GO:0071716 IMP
    sphingolipid translocation GO:0099039 IEA
    sphingolipid translocation GO:0099039 ISO
    export across plasma membrane GO:0140115 IMP
    export across plasma membrane GO:0140115 ISO
    cellular response to amyloid-beta GO:1904646 IMP
    carboxylic acid transmembrane transport GO:1905039 ISO
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 IEA
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 ISO
    xenobiotic transport across blood-brain barrier GO:1990962 IEA
    xenobiotic transport across blood-brain barrier GO:1990962 ISO
    regulation of cellular response to drug GO:2001038 IEA
    regulation of cellular response to drug GO:2001038 ISO
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    basal plasma membrane GO:0009925 IMP
    basal plasma membrane GO:0009925 ISO
    basolateral plasma membrane GO:0016323 IBA
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    lateral plasma membrane GO:0016328 IEA
    lateral plasma membrane GO:0016328 ISO
 Experiment description of studies that identified Abcc1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Abcc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lpgat1  
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Tm9sf3  
Co-fractionation Mus musculus
4 Npc1 18145
Co-fractionation Mus musculus
5 Fastkd5  
Co-fractionation Mus musculus
6 Yipf3  
Co-fractionation Mus musculus
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