Gene description for Npc1
Gene name	Niemann-Pick type C1
Gene symbol	Npc1
Other names/aliases	A430089E03Rik C85354 D18Ertd139e D18Ertd723e lcsd nmf164 spm
Species	Mus musculus
Database cross references - Npc1
ExoCarta	ExoCarta_18145
Vesiclepedia	VP_18145
Entrez Gene	18145
UniProt	O35604
Npc1 identified in sEVs derived from the following tissue/cell type
Melanoma cells	34957415
Melanoma cells	34957415
Melanoma cells	34957415

Gene ontology annotations for Npc1

Molecular Function     protein binding GO:0005515 IPI     cholesterol binding GO:0015485 IBA     cholesterol binding GO:0015485 ISO     cholesterol binding GO:0015485 ISS     cholesterol transfer activity GO:0120020 IEA Biological Process     liver development GO:0001889 IMP     protein glycosylation GO:0006486 IDA     protein glycosylation GO:0006486 ISO     endocytosis GO:0006897 IMP     autophagy GO:0006914 ISO     lysosomal transport GO:0007041 ISS     adult walking behavior GO:0007628 IGI     cholesterol metabolic process GO:0008203 IEA     bile acid metabolic process GO:0008206 ISS     response to xenobiotic stimulus GO:0009410 IDA     gene expression GO:0010467 IMP     gene expression GO:0010467 IMP     cholesterol storage GO:0010878 IMP     programmed cell death GO:0012501 IMP     sterol transport GO:0015918 IBA     sterol transport GO:0015918 IMP     sterol metabolic process GO:0016125 IMP     macroautophagy GO:0016236 IGI     macroautophagy GO:0016236 IMP     negative regulation of macroautophagy GO:0016242 IGI     negative regulation of macroautophagy GO:0016242 IMP     neurogenesis GO:0022008 IMP     intestinal cholesterol absorption GO:0030299 IBA     cholesterol transport GO:0030301 IMP     cholesterol transport GO:0030301 ISO     cholesterol transport GO:0030301 ISS     membrane raft organization GO:0031579 IEA     membrane raft organization GO:0031579 ISO     intracellular lipid transport GO:0032365 ISO     intracellular lipid transport GO:0032365 ISS     intracellular cholesterol transport GO:0032367 ISO     intracellular cholesterol transport GO:0032367 ISS     cholesterol efflux GO:0033344 IMP     cholesterol efflux GO:0033344 ISO     cholesterol homeostasis GO:0042632 IBA     cholesterol homeostasis GO:0042632 IMP     cholesterol homeostasis GO:0042632 ISO     cholesterol homeostasis GO:0042632 ISS     response to cadmium ion GO:0046686 IEA     response to cadmium ion GO:0046686 ISO     symbiont entry into host cell GO:0046718 IMP     symbiont entry into host cell GO:0046718 ISO     establishment of localization in cell GO:0051649 IMP     cellular response to steroid hormone stimulus GO:0071383 IDA     cellular response to low-density lipoprotein particle stimulus GO:0071404 IDA     establishment of protein localization to membrane GO:0090150 IEA     establishment of protein localization to membrane GO:0090150 ISO     negative regulation of epithelial cell apoptotic process GO:1904036 IEA     negative regulation of epithelial cell apoptotic process GO:1904036 ISO     negative regulation of TORC1 signaling GO:1904262 ISO     negative regulation of TORC1 signaling GO:1904262 ISS     cyclodextrin metabolic process GO:2000900 IMP Subcellular Localization     extracellular region GO:0005576 IDA     nuclear envelope GO:0005635 IDA     nuclear envelope GO:0005635 ISO     nuclear envelope GO:0005635 ISS     lysosome GO:0005764 IDA     lysosome GO:0005764 IDA     lysosomal membrane GO:0005765 ISO     lysosomal membrane GO:0005765 ISS     endosome GO:0005768 IDA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum GO:0005783 ISS     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     membrane GO:0016020 IDA     late endosome membrane GO:0031902 ISO     late endosome membrane GO:0031902 ISS     vesicle GO:0031982 IDA     membrane raft GO:0045121 IDA     perinuclear region of cytoplasm GO:0048471 ISO     perinuclear region of cytoplasm GO:0048471 ISS