Gene description for Cd47
Gene name CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
Gene symbol Cd47
Other names/aliases 9130415E20Rik
AA407862
AI848868
AW108519
B430305P08Rik
IAP
Itgp
Species Mus musculus
 Database cross references - Cd47
ExoCarta ExoCarta_16423
Vesiclepedia VP_16423
Entrez Gene 16423
UniProt Q61735  
 Cd47 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cd47
Molecular Function
    protein binding GO:0005515 IPI
    thrombospondin receptor activity GO:0070053 IBA
    thrombospondin receptor activity GO:0070053 IEA
    thrombospondin receptor activity GO:0070053 ISO
    protein binding involved in heterotypic cell-cell adhesion GO:0086080 ISO
    cell-cell adhesion mediator activity GO:0098632 ISO
Biological Process
    angiogenesis GO:0001525 IEA
    apoptotic process GO:0006915 IEA
    inflammatory response GO:0006954 IDA
    opsonization GO:0008228 IDA
    positive regulation of cell population proliferation GO:0008284 ISO
    response to bacterium GO:0009617 IMP
    cell migration GO:0016477 ISO
    positive regulation of cell-cell adhesion GO:0022409 IBA
    positive regulation of cell-cell adhesion GO:0022409 IEA
    positive regulation of cell-cell adhesion GO:0022409 ISO
    regulation of type II interferon production GO:0032649 ISO
    regulation of interleukin-10 production GO:0032653 ISO
    regulation of interleukin-12 production GO:0032655 ISO
    regulation of interleukin-6 production GO:0032675 ISO
    regulation of tumor necrosis factor production GO:0032680 ISO
    regulation of nitric oxide biosynthetic process GO:0045428 IDA
    positive regulation of inflammatory response GO:0050729 IBA
    positive regulation of inflammatory response GO:0050729 IMP
    negative regulation of phagocytosis GO:0050765 ISO
    positive regulation of phagocytosis GO:0050766 IBA
    positive regulation of phagocytosis GO:0050766 IDA
    positive regulation of phagocytosis GO:0050766 ISO
    positive regulation of T cell activation GO:0050870 ISO
    positive regulation of stress fiber assembly GO:0051496 ISO
    regulation of Fc receptor mediated stimulatory signaling pathway GO:0060368 ISO
    positive regulation of activation-induced cell death of T cells GO:0070237 IMP
    monocyte aggregation GO:0070487 IMP
    cellular response to type II interferon GO:0071346 ISO
    cellular response to interleukin-1 GO:0071347 ISO
    cellular response to interleukin-12 GO:0071349 ISO
    ATP export GO:1904669 ISO
    regulation of synapse pruning GO:1905806 IDA
    regulation of synapse pruning GO:1905806 IEP
    regulation of synapse pruning GO:1905806 IMP
    positive regulation of monocyte extravasation GO:2000439 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 ISO
    extracellular exosome GO:0070062 IBA
    extracellular exosome GO:0070062 IDA
    presynapse GO:0098793 IDA
    presynapse GO:0098793 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Cd47 in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cd47
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Slc29a1 63959
Co-fractionation Mus musculus
2 Lamp2 16784
Co-fractionation Mus musculus
3 Cd63 12512
Co-fractionation Mus musculus
4 SNCA 6622
Affinity Capture-MS Homo sapiens
5 Npc1 18145
Co-fractionation Mus musculus
6 Sstr3  
Proximity Label-MS Mus musculus
7 Ubqln2  
Reconstituted Complex Mus musculus
8 Eltd1  
Co-fractionation Mus musculus
9 Lnpep 240028
Co-fractionation Mus musculus
10 Il13ra2  
Co-fractionation Mus musculus
11 Slc9a7  
Co-fractionation Mus musculus
12 Gp1ba  
Co-fractionation Mus musculus
13 Slc8b1  
Co-fractionation Mus musculus
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