Gene description for Mertk
Gene name	c-mer proto-oncogene tyrosine kinase
Gene symbol	Mertk
Other names/aliases	Eyk Mer Nyk nmf12
Species	Mus musculus
Database cross references - Mertk
ExoCarta	ExoCarta_17289
Vesiclepedia	VP_17289
Entrez Gene	17289
UniProt	Q60805
Mertk identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Mertk

Molecular Function     transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     natural killer cell differentiation GO:0001779 IGI     negative regulation of cytokine production GO:0001818 IGI     chromatin remodeling GO:0006338 IEA     phagocytosis GO:0006909 IBA     phagocytosis GO:0006909 ISO     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     multicellular organism development GO:0007275 IBA     spermatogenesis GO:0007283 IGI     nervous system development GO:0007399 IBA     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     cell migration GO:0016477 IBA     platelet activation GO:0030168 IMP     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     secretion by cell GO:0032940 IMP     substrate adhesion-dependent cell spreading GO:0034446 IMP     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     apoptotic cell clearance GO:0043277 IDA     apoptotic cell clearance GO:0043277 IGI     apoptotic cell clearance GO:0043277 IMP     apoptotic cell clearance GO:0043277 IMP     lymphocyte activation GO:0046649 IGI     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     positive regulation of phagocytosis GO:0050766 IEA     positive regulation of phagocytosis GO:0050766 ISO     negative regulation of lymphocyte activation GO:0051250 IGI     establishment of localization in cell GO:0051649 IMP     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI     retina development in camera-type eye GO:0060041 IMP     vagina development GO:0060068 IGI     neutrophil clearance GO:0097350 IGI     negative regulation of leukocyte apoptotic process GO:2000107 IEA     negative regulation of leukocyte apoptotic process GO:2000107 ISO Subcellular Localization     photoreceptor outer segment GO:0001750 IEA     photoreceptor outer segment GO:0001750 ISO     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     receptor complex GO:0043235 IBA