Gene description for Axl
Gene name AXL receptor tyrosine kinase
Gene symbol Axl
Other names/aliases AI323647
Ark
Tyro7
Ufo
Species Mus musculus
 Database cross references - Axl
ExoCarta ExoCarta_26362
Vesiclepedia VP_26362
Entrez Gene 26362
UniProt Q00993  
 Axl identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Axl
Molecular Function
    virus receptor activity GO:0001618 IEA
    virus receptor activity GO:0001618 ISO
    phosphatidylserine binding GO:0001786 IEA
    phosphatidylserine binding GO:0001786 ISO
    protein tyrosine kinase activity GO:0004713 ISO
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    myosin heavy chain binding GO:0032036 IEA
    myosin heavy chain binding GO:0032036 ISO
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    phosphatidylinositol 3-kinase binding GO:0043548 IEA
    phosphatidylinositol 3-kinase binding GO:0043548 ISO
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    neuron migration GO:0001764 IGI
    neuron migration GO:0001764 IMP
    natural killer cell differentiation GO:0001779 IBA
    natural killer cell differentiation GO:0001779 IGI
    negative regulation of cytokine production GO:0001818 IGI
    positive regulation of cytokine-mediated signaling pathway GO:0001961 IEA
    positive regulation of cytokine-mediated signaling pathway GO:0001961 ISO
    blood vessel remodeling GO:0001974 IMP
    chromatin remodeling GO:0006338 IEA
    phagocytosis GO:0006909 IBA
    phagocytosis GO:0006909 IGI
    phagocytosis GO:0006909 ISO
    apoptotic process GO:0006915 IMP
    inflammatory response GO:0006954 IMP
    enzyme-linked receptor protein signaling pathway GO:0007167 IGI
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    spermatogenesis GO:0007283 IGI
    nervous system development GO:0007399 IBA
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    macrophage cytokine production GO:0010934 IGI
    negative regulation of macrophage cytokine production GO:0010936 IGI
    cell migration GO:0016477 IBA
    forebrain cell migration GO:0021885 IGI
    cell differentiation GO:0030154 ISO
    platelet activation GO:0030168 IBA
    platelet activation GO:0030168 IMP
    animal organ regeneration GO:0031100 IEA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    tumor necrosis factor production GO:0032640 IGI
    negative regulation of type II interferon production GO:0032689 IEA
    negative regulation of type II interferon production GO:0032689 ISO
    negative regulation of tumor necrosis factor production GO:0032720 IGI
    positive regulation of natural killer cell differentiation GO:0032825 IEA
    positive regulation of natural killer cell differentiation GO:0032825 ISO
    secretion by cell GO:0032940 IMP
    erythrocyte homeostasis GO:0034101 IGI
    erythrocyte homeostasis GO:0034101 IMP
    substrate adhesion-dependent cell spreading GO:0034446 IMP
    cellular response to interferon-alpha GO:0035457 IEA
    cellular response to interferon-alpha GO:0035457 ISO
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    ovulation cycle GO:0042698 IGI
    negative regulation of apoptotic process GO:0043066 IBA
    negative regulation of apoptotic process GO:0043066 IGI
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of apoptotic process GO:0043066 ISO
    apoptotic cell clearance GO:0043277 IGI
    apoptotic cell clearance GO:0043277 IGI
    apoptotic cell clearance GO:0043277 IMP
    negative regulation of neuron apoptotic process GO:0043524 IGI
    negative regulation of neuron apoptotic process GO:0043524 IMP
    innate immune response GO:0045087 IEA
    lymphocyte activation GO:0046649 IGI
    symbiont entry into host cell GO:0046718 IEA
    symbiont entry into host cell GO:0046718 ISO
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IEA
    cell maturation GO:0048469 IEA
    positive regulation of pinocytosis GO:0048549 IEA
    positive regulation of pinocytosis GO:0048549 ISO
    response to axon injury GO:0048678 IEA
    negative regulation of lymphocyte activation GO:0051250 IGI
    neuron apoptotic process GO:0051402 IGI
    establishment of localization in cell GO:0051649 IGI
    establishment of localization in cell GO:0051649 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IBA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP
    vagina development GO:0060068 IGI
    cellular response to hydrogen peroxide GO:0070301 IEA
    cellular response to hydrogen peroxide GO:0070301 ISO
    cellular response to lipopolysaccharide GO:0071222 IEA
    cellular response to lipopolysaccharide GO:0071222 ISO
    dendritic cell differentiation GO:0097028 IEA
    neutrophil clearance GO:0097350 IGI
    positive regulation of viral life cycle GO:1903902 IEA
    positive regulation of viral life cycle GO:1903902 ISO
    negative regulation of dendritic cell apoptotic process GO:2000669 IEA
    negative regulation of dendritic cell apoptotic process GO:2000669 ISO
Subcellular Localization
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
    intracellular membrane-bounded organelle GO:0043231 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
    receptor complex GO:0043235 IBA
 Experiment description of studies that identified Axl in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Axl
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mertk 17289
Co-fractionation Mus musculus
2 Grb2 14784
Affinity Capture-Western Mus musculus
3 Nphs2  
Affinity Capture-MS Mus musculus
4 Ror1  
Co-fractionation Mus musculus
5 Erbb3  
Co-fractionation Mus musculus
6 Ntrk1  
Co-fractionation Mus musculus
7 Pik3r1  
Affinity Capture-Western Mus musculus
8 Tec  
Co-fractionation Mus musculus
9 Ret  
Co-fractionation Mus musculus
10 Kit  
Co-fractionation Mus musculus
11 Flt4  
Co-fractionation Mus musculus
12 Txk  
Co-fractionation Mus musculus
13 Ddr1  
Co-fractionation Mus musculus
14 Cfp  
Co-fractionation Mus musculus
15 Cybb 13058
Co-fractionation Mus musculus
16 Abl2  
Affinity Capture-Western Mus musculus
17 Btk  
Co-fractionation Mus musculus
18 Tyro3  
Affinity Capture-Western Mus musculus
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