Gene description for DOCK2
Gene name	dedicator of cytokinesis 2
Gene symbol	DOCK2
Other names/aliases	-
Species	Homo sapiens
Database cross references - DOCK2
ExoCarta	ExoCarta_1794
Vesiclepedia	VP_1794
Entrez Gene	1794
HGNC	2988
MIM	603122
UniProt	Q92608
DOCK2 identified in sEVs derived from the following tissue/cell type
B cells	20458337
B cells	20458337
Neuroblastoma cells	25944692
Thymus	23844026

Gene ontology annotations for DOCK2

Molecular Function     guanyl-nucleotide exchange factor activity GO:0005085 IBA     guanyl-nucleotide exchange factor activity GO:0005085 IDA     guanyl-nucleotide exchange factor activity GO:0005085 TAS     GTPase activator activity GO:0005096 IEA     protein binding GO:0005515 IPI     small GTPase binding GO:0031267 IBA     T cell receptor binding GO:0042608 IDA Biological Process     membrane raft polarization GO:0001766 IEA     establishment of T cell polarity GO:0001768 IEA     immunological synapse formation GO:0001771 IEA     myeloid dendritic cell activation involved in immune response GO:0002277 ISS     chemotaxis GO:0006935 IEA     small GTPase-mediated signal transduction GO:0007264 IEA     myoblast fusion GO:0007520 IBA     cell migration GO:0016477 IBA     actin cytoskeleton organization GO:0030036 TAS     macropinocytosis GO:0044351 ISS     positive thymic T cell selection GO:0045059 IEA     negative thymic T cell selection GO:0045060 IEA     alpha-beta T cell proliferation GO:0046633 IEA     positive regulation of phagocytosis GO:0050766 ISS     regulation of small GTPase mediated signal transduction GO:0051056 TAS Subcellular Localization     extracellular region GO:0005576 TAS     cytoplasm GO:0005737 IBA     cytosol GO:0005829 TAS     cytoskeleton GO:0005856 IEA     plasma membrane GO:0005886 IBA     membrane GO:0016020 HDA     specific granule lumen GO:0035580 TAS     extracellular exosome GO:0070062 HDA