Gene description for TRIM23
Gene name tripartite motif containing 23
Gene symbol TRIM23
Other names/aliases ARD1
ARFD1
RNF46
Species Homo sapiens
 Database cross references - TRIM23
ExoCarta ExoCarta_373
Vesiclepedia VP_373
Entrez Gene 373
HGNC 660
MIM 601747
UniProt P36406  
 TRIM23 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for TRIM23
Molecular Function
    GTPase activity GO:0003924 IDA
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IDA
    enzyme activator activity GO:0008047 TAS
    zinc ion binding GO:0008270 IEA
    GDP binding GO:0019003 IDA
    identical protein binding GO:0042802 IPI
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    intracellular protein transport GO:0006886 IBA
    positive regulation of autophagy GO:0010508 IDA
    vesicle-mediated transport GO:0016192 IBA
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IEA
    innate immune response GO:0045087 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 IDA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified TRIM23 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRIM23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAIP  
Two-hybrid Homo sapiens
2 UBE2H 7328
Two-hybrid Homo sapiens
3 KRT76 51350
Two-hybrid Homo sapiens
4 TNFAIP3 7128
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 ENKD1  
Two-hybrid Homo sapiens
6 NXT2  
Two-hybrid Homo sapiens
7 HSPB7  
Two-hybrid Homo sapiens
8 SET 6418
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GLTSCR1L  
Two-hybrid Homo sapiens
10 CXCL14  
Two-hybrid Homo sapiens
11 CPNE7 27132
Two-hybrid Homo sapiens
12 KIFC3 3801
Two-hybrid Homo sapiens
13 RBM15B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 KRT6A 3853
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 CARD9 64170
Two-hybrid Homo sapiens
16 GATA2  
Two-hybrid Homo sapiens
17 PPP1R15B  
Two-hybrid Homo sapiens
18 GMCL1P1  
Two-hybrid Homo sapiens
19 TSG101 7251
Two-hybrid Homo sapiens
20 MSRB3 253827
Two-hybrid Homo sapiens
21 EXOC3-AS1  
Two-hybrid Homo sapiens
22 POM121  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 IL16  
Two-hybrid Homo sapiens
24 TRIM55  
Two-hybrid Homo sapiens
25 FBF1  
Two-hybrid Homo sapiens
26 CYTH2 9266
Reconstituted Complex Homo sapiens
27 KAT5  
Two-hybrid Homo sapiens
28 ANKRD55  
Two-hybrid Homo sapiens
29 HAPLN2  
Two-hybrid Homo sapiens
30 RTP5  
Two-hybrid Homo sapiens
31 JRK  
Two-hybrid Homo sapiens
32 CWF19L2  
Two-hybrid Homo sapiens
33 LMO2  
Two-hybrid Homo sapiens
34 SPG21 51324
Two-hybrid Homo sapiens
35 ATPAF2 91647
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 TRIM28 10155
Co-purification Homo sapiens
37 SMG9 56006
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 ZNF408  
Two-hybrid Homo sapiens
39 UBE2E2  
Two-hybrid Homo sapiens
40 LENG1  
Two-hybrid Homo sapiens
41 PPP1R18 170954
Two-hybrid Homo sapiens
42 POLL  
Two-hybrid Homo sapiens
43 HGS 9146
Two-hybrid Homo sapiens
44 STK19  
Two-hybrid Homo sapiens
45 FAM193B 54540
Two-hybrid Homo sapiens
46 UBQLN1 29979
Two-hybrid Homo sapiens
47 TCEA2  
Two-hybrid Homo sapiens
48 ZNF20  
Two-hybrid Homo sapiens
49 MYOM1  
Two-hybrid Homo sapiens
50 USP2  
Two-hybrid Homo sapiens
51 RNF126  
Two-hybrid Homo sapiens
52 AKTIP  
Two-hybrid Homo sapiens
53 CREB5 9586
Two-hybrid Homo sapiens
54 ARNT2  
Two-hybrid Homo sapiens
55 CDC20B  
Two-hybrid Homo sapiens
56 PES1 23481
Affinity Capture-Western Homo sapiens
57 NFU1 27247
Two-hybrid Homo sapiens
58 IQCE 23288
Two-hybrid Homo sapiens
59 TACO1  
Two-hybrid Homo sapiens
60 NEDD9 4739
Two-hybrid Homo sapiens
61 AP3M1 26985
Two-hybrid Homo sapiens
62 AQP1 358
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
63 BAZ2B  
Two-hybrid Homo sapiens
64 TBK1 29110
Affinity Capture-Western Homo sapiens
65 RNF32  
Two-hybrid Homo sapiens
66 USP21  
Two-hybrid Homo sapiens
67 RUFY1 80230
Two-hybrid Homo sapiens
68 ZBTB16  
Two-hybrid Homo sapiens
69 EHHADH 1962
Two-hybrid Homo sapiens
70 FAM110A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
71 CCDC33 80125
Two-hybrid Homo sapiens
72 TRIM42  
Two-hybrid Homo sapiens
73 SCNM1  
Two-hybrid Homo sapiens
74 SNAI2  
Two-hybrid Homo sapiens
75 RSRC2  
Two-hybrid Homo sapiens
76 RNF213 57674
Two-hybrid Homo sapiens
77 UBE2I 7329
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 PPIL2  
Two-hybrid Homo sapiens
79 TBC1D22B  
Two-hybrid Homo sapiens
80 GEM  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
81 ALS2CR11  
Two-hybrid Homo sapiens
82 WDYHV1  
Two-hybrid Homo sapiens
83 FLJ38668  
Two-hybrid Homo sapiens
84 RIN1 9610
Two-hybrid Homo sapiens
85 PIAS2  
Two-hybrid Homo sapiens
86 KRT75 9119
Two-hybrid Homo sapiens
87 RAD18  
Two-hybrid Homo sapiens
88 IQUB  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
89 TRIM32 22954
Two-hybrid Homo sapiens
90 FAM133A 286499
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
91 UTP23  
Two-hybrid Homo sapiens
92 NOXA1  
Two-hybrid Homo sapiens
93 PRPF18  
Two-hybrid Homo sapiens
94 ZNF581  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
95 EAF2  
Two-hybrid Homo sapiens
96 NME8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 RCAN3  
Two-hybrid Homo sapiens
98 PRPF31 26121
Two-hybrid Homo sapiens
99 SIAH1  
Two-hybrid Homo sapiens
100 MRPL45 84311
Two-hybrid Homo sapiens
101 USP28 57646
Affinity Capture-MS Homo sapiens
102 TRIM63  
Two-hybrid Homo sapiens
103 ARFGAP1 55738
Two-hybrid Homo sapiens
104 POTEB3 102724631
Affinity Capture-MS Homo sapiens
105 CCDC25 55246
Two-hybrid Homo sapiens
106 SNRPB2 6629
Two-hybrid Homo sapiens
107 LINC00526  
Two-hybrid Homo sapiens
108 COX5B 1329
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
109 CBX8 57332
Two-hybrid Homo sapiens
110 RNF34  
Two-hybrid Homo sapiens
111 C19orf57  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
112 CUL3 8452
Affinity Capture-MS Homo sapiens
113 CDC73  
Two-hybrid Homo sapiens
114 SORBS3 10174
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
115 FAM83A  
Two-hybrid Homo sapiens
116 HOXB5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
117 SNRPB 6628
Two-hybrid Homo sapiens
118 UBE2L3 7332
Reconstituted Complex Homo sapiens
119 ZNF564  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
120 WDR25  
Two-hybrid Homo sapiens
121 SIRPA 140885
Two-hybrid Homo sapiens
122 SF1 7536
Two-hybrid Homo sapiens
123 PDE4D  
Two-hybrid Homo sapiens
124 PHF1  
Two-hybrid Homo sapiens
125 ZFAND2A  
Two-hybrid Homo sapiens
126 EGFR 1956
Affinity Capture-MS Homo sapiens
127 ZNF835  
Two-hybrid Homo sapiens
128 ZNF250  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
129 TRIM6  
Co-purification Homo sapiens
130 LOC729603  
Two-hybrid Homo sapiens
131 GPANK1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
132 MTFR2  
Two-hybrid Homo sapiens
133 LINC01018  
Two-hybrid Homo sapiens
134 Hoxa1  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
135 PLEKHA2 59339
Two-hybrid Homo sapiens
136 UBE2D2 7322
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
137 MRPL4 51073
Two-hybrid Homo sapiens
138 FAM90A1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
139 BAG1 573
Two-hybrid Homo sapiens
140 TCEANC  
Two-hybrid Homo sapiens
141 PKP4 8502
Two-hybrid Homo sapiens
142 UBE2E1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
143 FAM208B 54906
Two-hybrid Homo sapiens
144 RIBC1  
Two-hybrid Homo sapiens
145 TRIM27  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
146 GGA2 23062
Two-hybrid Homo sapiens
147 MYEF2 50804
Two-hybrid Homo sapiens
148 RIBC2  
Two-hybrid Homo sapiens
149 ZNF587  
Two-hybrid Homo sapiens
150 FHIT 2272
Two-hybrid Homo sapiens
151 CSRP2 1466
Two-hybrid Homo sapiens
152 DCX  
Two-hybrid Homo sapiens
153 TXNDC5 81567
Two-hybrid Homo sapiens
154 SUMO1P1  
Two-hybrid Homo sapiens
155 LGALS8 3964
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
156 ZC2HC1C  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
157 ENTHD2  
Two-hybrid Homo sapiens
158 ZNF417  
Two-hybrid Homo sapiens
159 MDM2  
Two-hybrid Homo sapiens
160 TSHZ3  
Two-hybrid Homo sapiens
161 UBE2U  
Two-hybrid Homo sapiens
162 FAM103A1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
163 UBE2D3 7323
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
164 UBE2D1 7321
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
165 ANKRD36BP1  
Two-hybrid Homo sapiens
166 NUDT21 11051
Two-hybrid Homo sapiens
167 GGA3 23163
Two-hybrid Homo sapiens
168 C8orf33 65265
Two-hybrid Homo sapiens
169 DOCK2 1794
Two-hybrid Homo sapiens
170 SLC25A6 293
Two-hybrid Homo sapiens
171 SNAI1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
172 CFAP53  
Two-hybrid Homo sapiens
173 HAUS1  
Two-hybrid Homo sapiens
174 VGLL1  
Two-hybrid Homo sapiens
175 NEK6 10783
Two-hybrid Homo sapiens
176 CCDC146  
Two-hybrid Homo sapiens
177 DMC1  
Two-hybrid Homo sapiens
178 ATXN7  
Two-hybrid Homo sapiens
179 LGALS3 3958
Reconstituted Complex Homo sapiens
180 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
181 ZBTB4 57659
Two-hybrid Homo sapiens
182 PITX1  
Two-hybrid Homo sapiens
183 MKRN3  
Two-hybrid Homo sapiens
184 TROAP  
Two-hybrid Homo sapiens
185 CYTH1 9267
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
186 MLH1 4292
Two-hybrid Homo sapiens
187 ARHGEF3 50650
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
188 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
189 UBOX5  
Two-hybrid Homo sapiens
190 DDX58 23586
Affinity Capture-RNA Homo sapiens
191 GLIDR  
Two-hybrid Homo sapiens
192 ZNF474  
Two-hybrid Homo sapiens
193 PSMA1 5682
Two-hybrid Homo sapiens
194 KLHL42  
Two-hybrid Homo sapiens
195 ANO1 55107
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
196 MYOZ1  
Two-hybrid Homo sapiens
197 LAGE3  
Two-hybrid Homo sapiens
198 POTEB2 100287399
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 TRIM23 373
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
200 NAB2 4665
Two-hybrid Homo sapiens
201 TRIM31  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
202 JOSD1  
Two-hybrid Homo sapiens
203 MORN4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
204 CCDC13 152206
Two-hybrid Homo sapiens
205 CDR2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
206 PIK3R2 5296
Two-hybrid Homo sapiens
207 SNW1 22938
Two-hybrid Homo sapiens
208 TMSB4X 7114
Two-hybrid Homo sapiens
209 SH2D4A 63898
Two-hybrid Homo sapiens
210 TRIM29 23650
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
211 TEX33  
Two-hybrid Homo sapiens
212 FLAD1 80308
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
213 REPIN1  
Affinity Capture-MS Homo sapiens
214 TSEN54  
Two-hybrid Homo sapiens
215 GPKOW  
Two-hybrid Homo sapiens
216 LNX1  
Two-hybrid Homo sapiens
217 USP20  
Two-hybrid Homo sapiens
218 TRAF1 7185
Two-hybrid Homo sapiens
219 DMRT3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRIM23 is involved
No pathways found





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