Gene description for Ptgs2
Gene name	prostaglandin-endoperoxide synthase 2
Gene symbol	Ptgs2
Other names/aliases	COX2 Cox-2 PGHS-2 PHS-2 Pghs2 TIS10
Species	Mus musculus
Database cross references - Ptgs2
ExoCarta	ExoCarta_19225
Vesiclepedia	VP_19225
Entrez Gene	19225
UniProt	Q05769
Ptgs2 identified in sEVs derived from the following tissue/cell type
Basophilic leukemia cells	20424270

Gene ontology annotations for Ptgs2

Molecular Function     peroxidase activity GO:0004601 IEA     prostaglandin-endoperoxide synthase activity GO:0004666 IBA     prostaglandin-endoperoxide synthase activity GO:0004666 IDA     prostaglandin-endoperoxide synthase activity GO:0004666 ISO     protein binding GO:0005515 IPI     oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 IBA     oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 IEA     oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 ISO     enzyme binding GO:0019899 IEA     enzyme binding GO:0019899 ISO     heme binding GO:0020037 IDA     protein homodimerization activity GO:0042803 IPI     metal ion binding GO:0046872 IEA Biological Process     prostaglandin biosynthetic process GO:0001516 IDA     prostaglandin biosynthetic process GO:0001516 ISO     angiogenesis GO:0001525 IEA     angiogenesis GO:0001525 ISO     response to oxidative stress GO:0006979 IEA     embryo implantation GO:0007566 IMP     embryo implantation GO:0007566 ISO     learning GO:0007612 IEA     learning GO:0007612 ISO     memory GO:0007613 IEA     memory GO:0007613 ISO     regulation of blood pressure GO:0008217 IMP     positive regulation of cell population proliferation GO:0008284 ISO     negative regulation of cell population proliferation GO:0008285 IEA     negative regulation of cell population proliferation GO:0008285 ISO     response to xenobiotic stimulus GO:0009410 IEA     response to nematode GO:0009624 IDA     response to nematode GO:0009624 IMP     response to fructose GO:0009750 IEA     response to manganese ion GO:0010042 IEA     response to selenium ion GO:0010269 IDA     positive regulation of vascular endothelial growth factor production GO:0010575 IEA     positive regulation of vascular endothelial growth factor production GO:0010575 ISO     cyclooxygenase pathway GO:0019371 IBA     cyclooxygenase pathway GO:0019371 IDA     cyclooxygenase pathway GO:0019371 IDA     cyclooxygenase pathway GO:0019371 ISO     keratinocyte differentiation GO:0030216 NAS     bone mineralization GO:0030282 ISO     positive regulation of prostaglandin biosynthetic process GO:0031394 IMP     positive regulation of fever generation GO:0031622 IDA     positive regulation of fever generation GO:0031622 ISO     positive regulation of synaptic plasticity GO:0031915 IEA     positive regulation of synaptic plasticity GO:0031915 ISO     negative regulation of synaptic transmission, dopaminergic GO:0032227 IEA     negative regulation of synaptic transmission, dopaminergic GO:0032227 ISO     prostaglandin secretion GO:0032310 IMP     response to estradiol GO:0032355 IEA     response to lipopolysaccharide GO:0032496 ISO     positive regulation of peptidyl-serine phosphorylation GO:0033138 IMP     response to vitamin D GO:0033280 IEA     response to cytokine GO:0034097 ISO     cellular response to heat GO:0034605 IEA     response to tumor necrosis factor GO:0034612 IEA     maintenance of blood-brain barrier GO:0035633 IEA     maintenance of blood-brain barrier GO:0035633 ISO     regulation of cell population proliferation GO:0042127 IGI     positive regulation of protein import into nucleus GO:0042307 IEA     positive regulation of protein import into nucleus GO:0042307 ISO     hair cycle GO:0042633 IEA     anagen GO:0042640 IMP     positive regulation of apoptotic process GO:0043065 IEA     positive regulation of apoptotic process GO:0043065 ISO     negative regulation of apoptotic process GO:0043066 IMP     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     negative regulation of cell cycle GO:0045786 IEA     negative regulation of cell cycle GO:0045786 ISO     positive regulation of vasoconstriction GO:0045907 IEA     positive regulation of vasoconstriction GO:0045907 ISO     negative regulation of smooth muscle contraction GO:0045986 IEA     negative regulation of smooth muscle contraction GO:0045986 ISO     positive regulation of smooth muscle contraction GO:0045987 IEA     positive regulation of smooth muscle contraction GO:0045987 ISO     decidualization GO:0046697 IMP     decidualization GO:0046697 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     brown fat cell differentiation GO:0050873 IMP     response to glucocorticoid GO:0051384 IEA     negative regulation of calcium ion transport GO:0051926 IEA     negative regulation of calcium ion transport GO:0051926 ISO     positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO     response to fatty acid GO:0070542 IEA     cellular response to lipopolysaccharide GO:0071222 IEA     cellular response to mechanical stimulus GO:0071260 IEA     cellular response to lead ion GO:0071284 IEA     cellular response to ATP GO:0071318 IEA     cellular response to hypoxia GO:0071456 IEA     cellular response to non-ionic osmotic stress GO:0071471 IMP     cellular response to fluid shear stress GO:0071498 IDA     positive regulation of transforming growth factor beta production GO:0071636 IEA     positive regulation of transforming growth factor beta production GO:0071636 ISO     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 IEA     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO     positive regulation of fibroblast growth factor production GO:0090271 IEA     positive regulation of fibroblast growth factor production GO:0090271 ISO     positive regulation of brown fat cell differentiation GO:0090336 IMP     positive regulation of platelet-derived growth factor production GO:0090362 IEA     positive regulation of platelet-derived growth factor production GO:0090362 ISO     cellular oxidant detoxification GO:0098869 IEA     regulation of neuroinflammatory response GO:0150077 IDA     negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219 IMP     cellular response to homocysteine GO:1905375 IEA     response to angiotensin GO:1990776 IEA     negative regulation of cysteine-type endopeptidase activity GO:2000117 IMP Subcellular Localization     nucleus GO:0005634 IDA     nuclear inner membrane GO:0005637 IDA     nuclear inner membrane GO:0005637 ISO     nuclear outer membrane GO:0005640 IDA     nuclear outer membrane GO:0005640 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 IMP     cytoplasm GO:0005737 ISO     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum membrane GO:0005789 IEA     caveola GO:0005901 IEA     caveola GO:0005901 ISO     protein-containing complex GO:0032991 IEA     protein-containing complex GO:0032991 ISO     neuron projection GO:0043005 IBA     neuron projection GO:0043005 IDA     neuron projection GO:0043005 ISO