Gene description for FBXO45
Gene name F-box protein 45
Gene symbol FBXO45
Other names/aliases Fbx45
Species Homo sapiens
 Database cross references - FBXO45
ExoCarta ExoCarta_200933
Vesiclepedia VP_200933
Entrez Gene 200933
HGNC 29148
MIM 609112
UniProt P0C2W1  
 FBXO45 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FBXO45
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IDA
Biological Process
    neuron migration GO:0001764 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    DNA damage response GO:0006974 IDA
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 ISS
    cerebral cortex radially oriented cell migration GO:0021799 IEA
    cerebral cortex tangential migration GO:0021800 IEA
    corticospinal tract morphogenesis GO:0021957 IEA
    anterior commissure morphogenesis GO:0021960 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    synapse assembly involved in innervation GO:0060386 IBA
    protein K48-linked ubiquitination GO:0070936 IDA
    regulation of synaptic vesicle exocytosis GO:2000300 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IC
    postsynaptic density GO:0014069 IEA
    SCF ubiquitin ligase complex GO:0019005 IBA
    presynaptic membrane GO:0042734 IEA
    cell projection GO:0042995 IEA
    synapse GO:0045202 IBA
    postsynaptic membrane GO:0045211 IEA
    glutamatergic synapse GO:0098978 IEA
    presynaptic cytosol GO:0099523 IEA
    postsynaptic cytosol GO:0099524 IEA
 Experiment description of studies that identified FBXO45 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FBXO45
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 NEURL4  
Affinity Capture-MS Homo sapiens
4 TLR10  
Affinity Capture-MS Homo sapiens
5 CCT7 10574
Affinity Capture-MS Homo sapiens
6 MECP2 4204
Affinity Capture-MS Homo sapiens
7 INHBE 83729
Affinity Capture-MS Homo sapiens
8 CUL1 8454
Affinity Capture-MS Homo sapiens
9 GRN 2896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ZNF780A  
Affinity Capture-MS Homo sapiens
11 NMNAT2  
Affinity Capture-MS Homo sapiens
12 STAT2 6773
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MYCBP2 23077
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SVIL 6840
Affinity Capture-MS Homo sapiens
15 SHROOM3 57619
Affinity Capture-MS Homo sapiens
16 CLEC11A 6320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PRNP 5621
Two-hybrid Homo sapiens
18 HEYL  
Affinity Capture-Western Homo sapiens
19 PAWR 5074
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
20 EEA1 8411
Affinity Capture-MS Homo sapiens
21 CCT2 10576
Affinity Capture-MS Homo sapiens
22 IL25  
Affinity Capture-MS Homo sapiens
23 CCT6A 908
Affinity Capture-MS Homo sapiens
24 Skp1a 21402
Affinity Capture-MS Mus musculus
25 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
26 EPHB2 2048
Affinity Capture-MS Homo sapiens
27 USP49 25862
Affinity Capture-Western Homo sapiens
28 ARSB 411
Affinity Capture-MS Homo sapiens
29 SKP1 6500
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
30 CUL3 8452
Affinity Capture-MS Homo sapiens
31 YWHAB 7529
Affinity Capture-MS Homo sapiens
32 CTNNA2 1496
Affinity Capture-MS Homo sapiens
33 PUM2 23369
Affinity Capture-MS Homo sapiens
34 USP11 8237
Affinity Capture-MS Homo sapiens
35 CALM1 801
Affinity Capture-MS Homo sapiens
36 IGFBP4 3487
Affinity Capture-MS Homo sapiens
37 FAXC  
Affinity Capture-MS Homo sapiens
38 TP73  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
39 MEX3C 51320
Affinity Capture-MS Homo sapiens
40 HEY1  
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
41 HEY2  
Affinity Capture-Western Homo sapiens
42 ESR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
43 KIF1A 547
Affinity Capture-MS Homo sapiens
44 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PIGN 23556
Affinity Capture-MS Homo sapiens
46 FBXW7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ARHGEF2 9181
Affinity Capture-MS Homo sapiens
48 FAT4 79633
Affinity Capture-MS Homo sapiens
49 NCKAP5  
Affinity Capture-MS Homo sapiens
50 PCDH10 57575
Affinity Capture-MS Homo sapiens
51 VCP 7415
Affinity Capture-MS Homo sapiens
52 TRIM21 6737
Affinity Capture-MS Homo sapiens
53 INSL6  
Affinity Capture-MS Homo sapiens
54 CETN1  
Affinity Capture-MS Homo sapiens
55 GALC 2581
Affinity Capture-MS Homo sapiens
56 SPRYD3 84926
Affinity Capture-MS Homo sapiens
57 RBPMS2  
Affinity Capture-MS Homo sapiens
58 NGRN  
Affinity Capture-MS Homo sapiens
59 CDH2 1000
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
60 NOS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 ALPK2  
Affinity Capture-MS Homo sapiens
62 RFC4 5984
Affinity Capture-MS Homo sapiens
63 ABCA2 20
Affinity Capture-MS Homo sapiens
64 TDGF1  
Affinity Capture-MS Homo sapiens
65 HECTD1 25831
Affinity Capture-MS Homo sapiens
66 YWHAG 7532
Affinity Capture-MS Homo sapiens
67 POGLUT1 56983
Affinity Capture-MS Homo sapiens
68 MARCH5  
Affinity Capture-MS Homo sapiens
69 GDF10 2662
Affinity Capture-MS Homo sapiens
70 METTL15  
Affinity Capture-MS Homo sapiens
71 CCT4 10575
Affinity Capture-MS Homo sapiens
72 CDH19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 MMP13  
Affinity Capture-MS Homo sapiens
74 CASQ2 845
Affinity Capture-MS Homo sapiens
75 Lgals3bp 19039
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which FBXO45 is involved
No pathways found





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