Gene description for S100a10
Gene name S100 calcium binding protein A10 (calpactin)
Gene symbol S100a10
Other names/aliases 42C
AA409961
AL024248
CAL12
CLP11
Cal1l
p10
p11
Species Mus musculus
 Database cross references - S100a10
ExoCarta ExoCarta_20194
Vesiclepedia VP_20194
Entrez Gene 20194
UniProt P08207  
 S100a10 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Microglia 16081791    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for S100a10
Molecular Function
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    transmembrane transporter binding GO:0044325 IBA
    transmembrane transporter binding GO:0044325 IEA
    transmembrane transporter binding GO:0044325 ISO
    calcium-dependent protein binding GO:0048306 IBA
Biological Process
    membrane raft assembly GO:0001765 IEA
    membrane raft assembly GO:0001765 ISO
    vesicle budding from membrane GO:0006900 IEA
    vesicle budding from membrane GO:0006900 ISO
    positive regulation of plasminogen activation GO:0010756 ISO
    mRNA transcription by RNA polymerase II GO:0042789 IDA
    positive regulation of GTPase activity GO:0043547 ISO
    positive regulation of exocytosis GO:0045921 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    regulation of neurogenesis GO:0050767 IDA
    positive regulation of binding GO:0051099 IMP
    positive regulation of stress fiber assembly GO:0051496 IEA
    positive regulation of stress fiber assembly GO:0051496 ISO
    positive regulation of focal adhesion assembly GO:0051894 IEA
    positive regulation of focal adhesion assembly GO:0051894 ISO
    cellular response to acid chemical GO:0071229 IDA
    protein localization to plasma membrane GO:0072659 IEA
    protein localization to plasma membrane GO:0072659 ISO
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IEA
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO
    positive regulation of plasma membrane repair GO:1905686 NAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 IDA
    nuclear matrix GO:0016363 NAS
    membrane raft GO:0045121 IEA
    membrane raft GO:0045121 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
    RNA polymerase II transcription regulator complex GO:0090575 IPI
    RNA polymerase II transcription regulator complex GO:0090575 ISO
    plasma membrane protein complex GO:0098797 EXP
    plasma membrane protein complex GO:0098797 IPI
    plasma membrane protein complex GO:0098797 ISO
    AnxA2-p11 complex GO:1990665 IEA
    AnxA2-p11 complex GO:1990665 ISO
 Experiment description of studies that identified S100a10 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 14
MISEV standards
✔
EM
Biophysical techniques
✔
RAB7|RAB11|CD9|CD63|LAMP1|LAMP2
Enriched markers
✔
DNM
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors "Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L"
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for S100a10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hltf  
Affinity Capture-Western Mus musculus
Protein-peptide Mus musculus
Co-crystal Structure Mus musculus
Co-fractionation Mus musculus
2 Ubc  
Reconstituted Complex Mus musculus
3 Anxa2 12306
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
4 Trpv5  
Co-fractionation Mus musculus
5 Ahnak  
Protein-peptide Mus musculus
Co-crystal Structure Mus musculus
6 Anxa1 16952
Co-fractionation Mus musculus
7 Ahnak2  
Protein-peptide Mus musculus
View the network image/svg+xml
 Pathways in which S100a10 is involved
PathwayEvidenceSource
Dissolution of Fibrin Clot IEA Reactome
Hemostasis IEA Reactome





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