Gene description for S100a11
Gene name S100 calcium binding protein A11 (calgizzarin)
Gene symbol S100a11
Other names/aliases EMAPI
Emap1
S100a14
S100c
cal
Species Mus musculus
 Database cross references - S100a11
ExoCarta ExoCarta_20195
Vesiclepedia VP_20195
Entrez Gene 20195
UniProt P50543  
 S100a11 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for S100a11
Molecular Function
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IEA
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    S100 protein binding GO:0044548 IBA
    S100 protein binding GO:0044548 IEA
    S100 protein binding GO:0044548 ISO
    calcium-dependent protein binding GO:0048306 IBA
    calcium-dependent protein binding GO:0048306 IEA
    calcium-dependent protein binding GO:0048306 ISO
Biological Process
    spermatogenesis GO:0007283 IMP
    positive regulation of smooth muscle cell migration GO:0014911 IEA
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    regulation of cell population proliferation GO:0042127 IEA
Subcellular Localization
    ruffle GO:0001726 IEA
    ruffle GO:0001726 ISO
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified S100a11 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for S100a11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Gbp3  
Co-fractionation Mus musculus
3 Anxa2 12306
Co-fractionation Mus musculus
4 Nudt14  
Co-fractionation Mus musculus
5 Hadha  
Co-fractionation Mus musculus
6 Lamp2 16784
Co-fractionation Mus musculus
7 Rock1  
Co-fractionation Mus musculus
8 Tnfaip8  
Co-fractionation Mus musculus
9 Cpt2  
Co-fractionation Mus musculus
10 Mettl21e  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which S100a11 is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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