Gene description for EPO
Gene name	erythropoietin
Gene symbol	EPO
Other names/aliases	EP MVCD2
Species	Homo sapiens
Database cross references - EPO
ExoCarta	ExoCarta_2056
Vesiclepedia	VP_2056
Entrez Gene	2056
HGNC	3415
MIM	133170
UniProt	P01588
EPO identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for EPO

Molecular Function     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IDA     erythropoietin receptor binding GO:0005128 IBA     erythropoietin receptor binding GO:0005128 IMP     hormone activity GO:0005179 IDA     protein binding GO:0005515 IPI     protein kinase activator activity GO:0030295 IBA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     response to hypoxia GO:0001666 IEA     acute-phase response GO:0006953 IEA     signal transduction GO:0007165 NAS     embryo implantation GO:0007566 IEA     blood circulation GO:0008015 NAS     positive regulation of cell population proliferation GO:0008284 IBA     positive regulation of cell population proliferation GO:0008284 IDA     response to salt stress GO:0009651 IEA     negative regulation of calcium ion transport into cytosol GO:0010523 IDA     positive regulation of neuron projection development GO:0010976 IEA     erythrocyte differentiation GO:0030218 IDA     erythrocyte differentiation GO:0030218 IMP     response to lipopolysaccharide GO:0032496 IEA     myeloid cell apoptotic process GO:0033028 IEA     response to vitamin A GO:0033189 IEA     response to testosterone GO:0033574 IEA     erythropoietin-mediated signaling pathway GO:0038162 IBA     erythropoietin-mediated signaling pathway GO:0038162 IDA     erythropoietin-mediated signaling pathway GO:0038162 IMP     positive regulation of activated T cell proliferation GO:0042104 IEA     hemoglobin biosynthetic process GO:0042541 IEA     erythrocyte maturation GO:0043249 IEA     response to estrogen GO:0043627 IEA     positive regulation of neuron differentiation GO:0045666 IEA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of Ras protein signal transduction GO:0046579 IBA     positive regulation of Ras protein signal transduction GO:0046579 IDA     response to axon injury GO:0048678 IEA     response to electrical stimulus GO:0051602 IEA     response to hyperoxia GO:0055093 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     response to interleukin-1 GO:0070555 IEA     cellular hyperosmotic response GO:0071474 IDA     response to dexamethasone GO:0071548 IEA     cell surface receptor signaling pathway via STAT GO:0097696 IDA     negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219 IDA     negative regulation of erythrocyte apoptotic process GO:1902251 IDA     negative regulation of cation channel activity GO:2001258 IDA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IDA     cell surface GO:0009986 IDA     cell body GO:0044297 IEA