Gene description for HIF1A
Gene name	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Gene symbol	HIF1A
Other names/aliases	HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78
Species	Homo sapiens
Database cross references - HIF1A
ExoCarta	ExoCarta_3091
Vesiclepedia	VP_3091
Entrez Gene	3091
HGNC	4910
MIM	603348
UniProt	Q16665
HIF1A identified in sEVs derived from the following tissue/cell type
Kidney cancer cells	35333565
Retinal pigment epithelial cells	35333565

Gene ontology annotations for HIF1A

Molecular Function     RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA     RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IMP     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     cis-regulatory region sequence-specific DNA binding GO:0000987 IMP     DNA-binding transcription activator activity GO:0001216 IMP     DNA-binding transcription repressor activity GO:0001217 IMP     transcription coactivator binding GO:0001223 IPI     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP     p53 binding GO:0002039 EXP     p53 binding GO:0002039 IDA     p53 binding GO:0002039 IPI     DNA-binding transcription factor activity GO:0003700 IDA     protein binding GO:0005515 IPI     nuclear receptor binding GO:0016922 IPI     enzyme binding GO:0019899 IPI     protein kinase binding GO:0019901 IPI     protein domain specific binding GO:0019904 IPI     ubiquitin protein ligase binding GO:0031625 EXP     ubiquitin protein ligase binding GO:0031625 IPI     histone deacetylase binding GO:0042826 IEA     sequence-specific DNA binding GO:0043565 IDA     protein heterodimerization activity GO:0046982 IPI     Hsp90 protein binding GO:0051879 IDA     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     E-box binding GO:0070888 IEA     transcription regulator activator activity GO:0140537 IPI Biological Process     response to reactive oxygen species GO:0000302 IDA     angiogenesis GO:0001525 IEA     response to hypoxia GO:0001666 IDA     response to hypoxia GO:0001666 IDA     response to hypoxia GO:0001666 IMP     intracellular glucose homeostasis GO:0001678 IDA     neural crest cell migration GO:0001755 IEA     epithelial to mesenchymal transition GO:0001837 ISS     embryonic placenta development GO:0001892 IEA     B-1 B cell homeostasis GO:0001922 IEA     positive regulation of endothelial cell proliferation GO:0001938 IC     heart looping GO:0001947 IEA     positive regulation of neuroblast proliferation GO:0002052 IEA     chondrocyte differentiation GO:0002062 IEA     glandular epithelial cell maturation GO:0002071 IEA     connective tissue replacement involved in inflammatory response wound healing GO:0002248 ISS     outflow tract morphogenesis GO:0003151 IEA     cardiac ventricle morphogenesis GO:0003208 IEA     lactate metabolic process GO:0006089 IEA     regulation of glycolytic process GO:0006110 IDA     regulation of DNA-templated transcription GO:0006355 IDA     regulation of DNA-templated transcription GO:0006355 IDA     regulation of transcription by RNA polymerase II GO:0006357 IBA     intracellular iron ion homeostasis GO:0006879 IEA     signal transduction GO:0007165 IMP     neuroblast proliferation GO:0007405 IEA     lactation GO:0007595 IEA     visual learning GO:0008542 IEA     response to iron ion GO:0010039 IEP     regulation of gene expression GO:0010468 IDA     vascular endothelial growth factor production GO:0010573 IDA     positive regulation of vascular endothelial growth factor production GO:0010575 IDA     positive regulation of vascular endothelial growth factor production GO:0010575 IMP     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 IMP     negative regulation of gene expression GO:0010629 IMP     positive regulation of epithelial cell migration GO:0010634 ISS     response to muscle activity GO:0014850 IEA     axonal transport of mitochondrion GO:0019896 IMP     neural fold elevation formation GO:0021502 IEA     cerebral cortex development GO:0021987 IEA     bone mineralization GO:0030282 IEA     negative regulation of bone mineralization GO:0030502 IEA     positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 IC     TOR signaling GO:0031929 IEA     negative regulation of TOR signaling GO:0032007 IEA     intracellular oxygen homeostasis GO:0032364 IDA     positive regulation of chemokine production GO:0032722 TAS     regulation of transforming growth factor beta2 production GO:0032909 IMP     collagen metabolic process GO:0032963 ISS     cellular response to oxidative stress GO:0034599 IDA     embryonic hemopoiesis GO:0035162 IEA     insulin secretion involved in cellular response to glucose stimulus GO:0035773 IEA     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA     hemoglobin biosynthetic process GO:0042541 IEA     positive regulation of blood vessel endothelial cell migration GO:0043536 IMP     positive regulation of erythrocyte differentiation GO:0045648 IC     positive regulation of angiogenesis GO:0045766 IC     positive regulation of angiogenesis GO:0045766 IMP     positive regulation of glycolytic process GO:0045821 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     negative regulation of growth GO:0045926 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     muscle cell cellular homeostasis GO:0046716 IEA     positive regulation of hormone biosynthetic process GO:0046886 IDA     digestive tract morphogenesis GO:0048546 IEA     positive regulation of nitric-oxide synthase activity GO:0051000 TAS     neuron apoptotic process GO:0051402 IEA     elastin metabolic process GO:0051541 ISS     intestinal epithelial cell maturation GO:0060574 IEA     epithelial cell differentiation involved in mammary gland alveolus development GO:0061030 IEA     iris morphogenesis GO:0061072 IEA     retina vasculature development in camera-type eye GO:0061298 IEA     positive regulation of chemokine-mediated signaling pathway GO:0070101 IDA     negative regulation of thymocyte apoptotic process GO:0070244 IEA     cellular response to interleukin-1 GO:0071347 IEP     cellular response to hypoxia GO:0071456 IBA     cellular response to hypoxia GO:0071456 IDA     cellular response to hypoxia GO:0071456 IEP     cellular response to hypoxia GO:0071456 IMP     dopaminergic neuron differentiation GO:0071542 IEA     mesenchymal cell apoptotic process GO:0097152 IEA     hypoxia-inducible factor-1alpha signaling pathway GO:0097411 IEA     cellular response to virus GO:0098586 IDA     positive regulation of cytokine production involved in inflammatory response GO:1900017 IDA     positive regulation of mitophagy GO:1901526 IEA     negative regulation of miRNA transcription GO:1902894 IMP     positive regulation of miRNA transcription GO:1902895 IDA     positive regulation of miRNA transcription GO:1902895 IMP     negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 IDA     regulation of aerobic respiration GO:1903715 IEA     positive regulation of signaling receptor activity GO:2000273 IMP     negative regulation of reactive oxygen species metabolic process GO:2000378 IEA     regulation of protein neddylation GO:2000434 IMP     negative regulation of mesenchymal cell apoptotic process GO:2001054 IEA Subcellular Localization     chromatin GO:0000785 IDA     chromatin GO:0000785 ISA     euchromatin GO:0000791 IEA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     nuclear body GO:0016604 IDA     nuclear speck GO:0016607 ISS     motile cilium GO:0031514 IEA     protein-containing complex GO:0032991 IMP     RNA polymerase II transcription regulator complex GO:0090575 IDA     axon cytoplasm GO:1904115 IEA