Gene description for MTOR
Gene name	mechanistic target of rapamycin (serine/threonine kinase)
Gene symbol	MTOR
Other names/aliases	FRAP FRAP1 FRAP2 RAFT1 RAPT1
Species	Homo sapiens
Database cross references - MTOR
ExoCarta	ExoCarta_2475
Vesiclepedia	VP_2475
Entrez Gene	2475
HGNC	3942
MIM	601231
UniProt	P42345
MTOR identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Chondrocytes	35931686
Chondrocytes	35931686
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Hepatocellular carcinoma cells	26054723
Mesenchymal stem cells	36408942
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for MTOR

Molecular Function     inositol hexakisphosphate binding GO:0000822 IDA     RNA polymerase III type 1 promoter sequence-specific DNA binding GO:0001002 IDA     RNA polymerase III type 2 promoter sequence-specific DNA binding GO:0001003 IDA     RNA polymerase III type 3 promoter sequence-specific DNA binding GO:0001006 IDA     TFIIIC-class transcription factor complex binding GO:0001156 IDA     protein kinase activity GO:0004672 IDA     protein serine/threonine kinase activity GO:0004674 EXP     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 TAS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein tyrosine kinase activity GO:0004713 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     identical protein binding GO:0042802 IPI     ribosome binding GO:0043022 IDA     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     phosphoprotein binding GO:0051219 IPI     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     regulation of cell growth GO:0001558 IDA     T-helper 1 cell lineage commitment GO:0002296 IEA     heart morphogenesis GO:0003007 IEA     heart valve morphogenesis GO:0003179 IEA     energy reserve metabolic process GO:0006112 IEA     'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA     chromatin remodeling GO:0006338 IEA     inflammatory response GO:0006954 IEA     DNA damage response GO:0006974 NAS     cytoskeleton organization GO:0007010 NAS     germ cell development GO:0007281 IEA     regulation of cell size GO:0008361 IMP     cellular response to starvation GO:0009267 IDA     response to heat GO:0009408 IEA     post-embryonic development GO:0009791 IEA     negative regulation of autophagy GO:0010507 IDA     negative regulation of autophagy GO:0010507 IMP     negative regulation of autophagy GO:0010507 ISS     negative regulation of autophagy GO:0010507 NAS     positive regulation of lamellipodium assembly GO:0010592 IEA     positive regulation of epithelial to mesenchymal transition GO:0010718 IMP     positive regulation of myotube differentiation GO:0010831 IEA     macroautophagy GO:0016236 IEA     regulation of macroautophagy GO:0016241 TAS     negative regulation of macroautophagy GO:0016242 IBA     negative regulation of macroautophagy GO:0016242 IDA     neuronal action potential GO:0019228 IEA     positive regulation of cell growth GO:0030307 NAS     positive regulation of actin filament polymerization GO:0030838 IEA     T cell costimulation GO:0031295 TAS     ruffle organization GO:0031529 IEA     regulation of myelination GO:0031641 IEA     protein destabilization GO:0031648 IDA     response to nutrient levels GO:0031667 IDA     cellular response to nutrient levels GO:0031669 IDA     cellular response to nutrient levels GO:0031669 ISS     cellular response to nutrient levels GO:0031669 NAS     cellular response to nutrient GO:0031670 IDA     TOR signaling GO:0031929 IMP     TOR signaling GO:0031929 NAS     cellular response to insulin stimulus GO:0032869 IDA     regulation of actin cytoskeleton organization GO:0032956 IMP     calcineurin-NFAT signaling cascade GO:0033173 IEA     cellular response to amino acid starvation GO:0034198 IDA     multicellular organism growth GO:0035264 IEA     TORC1 signaling GO:0038202 IBA     TORC1 signaling GO:0038202 IDA     TORC1 signaling GO:0038202 IMP     TORC2 signaling GO:0038203 IDA     regulation of circadian rhythm GO:0042752 ISS     negative regulation of apoptotic process GO:0043066 NAS     response to amino acid GO:0043200 IDA     anoikis GO:0043276 NAS     regulation of osteoclast differentiation GO:0045670 ISS     positive regulation of translation GO:0045727 IDA     negative regulation of cell size GO:0045792 IEA     positive regulation of glycolytic process GO:0045821 NAS     positive regulation of transcription by RNA polymerase III GO:0045945 IMP     positive regulation of translational initiation GO:0045948 IDA     positive regulation of lipid biosynthetic process GO:0046889 IMP     positive regulation of lipid biosynthetic process GO:0046889 ISS     positive regulation of lipid biosynthetic process GO:0046889 NAS     behavioral response to pain GO:0048266 IEA     rhythmic process GO:0048511 IEA     oligodendrocyte differentiation GO:0048709 IEA     positive regulation of oligodendrocyte differentiation GO:0048714 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     voluntary musculoskeletal movement GO:0050882 IEA     positive regulation of stress fiber assembly GO:0051496 IEA     positive regulation of keratinocyte migration GO:0051549 IMP     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 TAS     cardiac muscle cell development GO:0055013 IEA     cardiac muscle contraction GO:0060048 IEA     cellular response to methionine GO:0061431 IDA     negative regulation of calcineurin-NFAT signaling cascade GO:0070885 IEA     cellular response to amino acid stimulus GO:0071230 IDA     cellular response to L-leucine GO:0071233 IDA     cellular response to hypoxia GO:0071456 ISS     cellular response to hypoxia GO:0071456 NAS     cellular response to osmotic stress GO:0071470 NAS     regulation of membrane permeability GO:0090559 IEA     regulation of cellular response to heat GO:1900034 TAS     negative regulation of protein localization to nucleus GO:1900181 IDA     regulation of signal transduction by p53 class mediator GO:1901796 TAS     positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 IMP     positive regulation of wound healing, spreading of epidermal cells GO:1903691 IMP     regulation of locomotor rhythm GO:1904059 ISS     positive regulation of cytoplasmic translational initiation GO:1904690 TAS     regulation of lysosome organization GO:1905671 IDA     negative regulation of lysosome organization GO:1905672 IDA     positive regulation of pentose-phosphate shunt GO:1905857 NAS     cellular response to leucine starvation GO:1990253 IDA     regulation of autophagosome assembly GO:2000785 IDA Subcellular Localization     Golgi membrane GO:0000139 IEA     nucleus GO:0005634 IBA     nuclear envelope GO:0005635 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     mitochondrial outer membrane GO:0005741 IEA     lysosome GO:0005764 IDA     lysosome GO:0005764 IMP     lysosomal membrane GO:0005765 HDA     lysosomal membrane GO:0005765 IDA     lysosomal membrane GO:0005765 IDA     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum membrane GO:0005789 IEA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     endomembrane system GO:0012505 IDA     membrane GO:0016020 HDA     membrane GO:0016020 IDA     PML body GO:0016605 ISS     dendrite GO:0030425 IEA     TORC1 complex GO:0031931 IBA     TORC1 complex GO:0031931 IDA     TORC1 complex GO:0031931 IMP     TORC1 complex GO:0031931 IPI     TORC2 complex GO:0031932 IBA     TORC2 complex GO:0031932 IDA     TORC2 complex GO:0031932 IPI     phagocytic vesicle GO:0045335 IDA