Gene description for CUL4A
Gene name	cullin 4A
Gene symbol	CUL4A
Other names/aliases	-
Species	Homo sapiens
Database cross references - CUL4A
ExoCarta	ExoCarta_8451
Vesiclepedia	VP_8451
Entrez Gene	8451
HGNC	2554
MIM	603137
UniProt	Q13619
CUL4A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Breast cancer cells	34108659
Breast cancer cells	34108659
Chondrocytes	35931686
Chondrocytes	35931686
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	34887515
Embryonic kidney cells	34108659
Foreskin fibroblasts	34108659
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Hepatocytes	26054723
Lymphoma cells	34108659
Mammary cancer-associated fibroblasts	34108659
Mesenchymal stem cells	36408942
Monocytic leukemia cells	34108659
Normal mammary epithelial cells	34108659
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Pancreatic cancer cells	34108659
Pancreatic cancer cells	34108659
Pancreatic duct epithalial cells	34108659
Pancreatic duct epithalial cells	34108659
Pluripotent stem cells	34108659
T lymphocytes	34108659
Thymus	23844026

Gene ontology annotations for CUL4A

Molecular Function     protein binding GO:0005515 IPI     ubiquitin protein ligase binding GO:0031625 IBA     ubiquitin protein ligase binding GO:0031625 IDA     ubiquitin protein ligase activity GO:0061630 IDA     ubiquitin ligase complex scaffold activity GO:0160072 IDA Biological Process     G1/S transition of mitotic cell cycle GO:0000082 TAS     in utero embryonic development GO:0001701 IEA     DNA repair GO:0006281 IEA     DNA damage response GO:0006974 EXP     DNA damage response GO:0006974 IBA     spermatogenesis GO:0007283 IDA     cell population proliferation GO:0008283 IEA     positive regulation of cell population proliferation GO:0008284 IEA     protein ubiquitination GO:0016567 IBA     protein ubiquitination GO:0016567 IDA     protein ubiquitination GO:0016567 IEA     protein ubiquitination GO:0016567 IMP     hemopoiesis GO:0030097 IEA     negative regulation of granulocyte differentiation GO:0030853 IEA     cellular response to UV GO:0034644 EXP     somatic stem cell population maintenance GO:0035019 IEA     T cell activation GO:0042110 IDA     ribosome biogenesis GO:0042254 IMP     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP     positive regulation of protein catabolic process GO:0045732 IDA     rhythmic process GO:0048511 IEA     intrinsic apoptotic signaling pathway GO:0097193 TAS     ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0140627 IDA     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA     regulation of DNA damage checkpoint GO:2000001 IEA     regulation of nucleotide-excision repair GO:2000819 IEA Subcellular Localization     nucleus GO:0005634 IC     nucleus GO:0005634 IDA     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     Cul4A-RING E3 ubiquitin ligase complex GO:0031464 EXP     Cul4A-RING E3 ubiquitin ligase complex GO:0031464 IBA     Cul4A-RING E3 ubiquitin ligase complex GO:0031464 IDA     Cul4-RING E3 ubiquitin ligase complex GO:0080008 IDA